PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM25	5	KANSL1	11	affinity chromatography technology	Choudhury NR (2017)	1
WDR5	2	MCRS1	1	affinity chromatography technology	Hauri S (2016)	1
TFG	3	PHF20	1	affinity chromatography technology	Hein MY (2015)	1
DDX42	3	PHF20	1	biochemical	Havugimana PC (2012)	1
TRIM25	5	DDX42	3	affinity chromatography technology	Choudhury NR (2017)	1
KANSL1	11	PHF20	1	affinity chromatography technology	Huttlin EL (2017)	1
PHF20	1	POLE3	0	biochemical	Wan C (2015)	1
KANSL1	11	KAT8	2	affinity chromatography technology, affinity chromatography technology, pull down	Li X (2009), Smith ER (2005), Kadlec J (2011)	3
PHF20	1	HIST1H4A	0	unspecified method	Adams-Cioaba MA (2012)	1
TP53	0	PHF20	1	affinity chromatography technology, affinity chromatography technology	Cui G (2012), Cui G (2012)	2
KANSL1	11	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology	Li X (2009), Huttlin EL (2015), Dias J (2014), Dias J (2014), Dias J (2014), Huttlin EL (2017), Hauri S (2016)	7
TFG	3	TRIM25	5	affinity chromatography technology	Lee NR (2013)	1
PHF20	1	PTPN14	5	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	KANSL2	6	affinity chromatography technology	Choudhury NR (2017)	1
PHF20	1	HIST1H3A	3	unspecified method	Adams-Cioaba MA (2012)	1
KANSL1	11	MCRS1	1	affinity chromatography technology	Huttlin EL (2017)	1
KAT8	2	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dou Y (2005), Sharma GG (2010), Hauri S (2016)	3
TRIM25	5	PHF20	1	affinity chromatography technology	Choudhury NR (2017)	1
PATL1	4	PHF20	1	biochemical	Havugimana PC (2012)	1
HIST1H3A	3	WDR5	2	affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Higa LA (2006), Schuetz A (2006), Couture JF (2006), Ruthenburg AJ (2006), Han Z (2006), Wysocka J (2005), Wysocka J (2005), Wysocka J (2005), Wysocka J (2005), Bailey JK (2015)	11
PHF20	1	MCRS1	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	KANSL3	1	affinity chromatography technology	Choudhury NR (2017)	1
KAT8	2	HIST1H4A	0	enzymatic study, affinity chromatography technology, imaging technique, enzymatic study	Smith ER (2005), Zippo A (2009), Zippo A (2009), Tropberger P (2013)	4
WDR5	2	KANSL3	1	affinity chromatography technology	Hauri S (2016)	1
PHF20	1	KANSL3	1	affinity chromatography technology	Huttlin EL (2017)	1
WDR5	2	KANSL2	6	biochemical, pull down, affinity chromatography technology	Dias J (2014), Dias J (2014), Hauri S (2016)	3
HIST1H3A	3	HIST1H4A	0	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Tagami H (2004), Shiio Y (2003), Zippo A (2009), Soldi M (2013), Klement K (2014), Sato K (2012)	6
KAT8	2	PHF20	1	affinity chromatography technology, affinity chromatography technology	Sharma GG (2010), Huttlin EL (2017)	2
WDR5	2	PHF20	1	affinity chromatography technology	Hauri S (2016)	1
MOV10	6	PHF20	1	affinity chromatography technology	Castello A (2012)	1
NXF1	0	POLE3	0	affinity chromatography technology	Castello A (2012)	1
MOV10	6	POLE3	0	affinity chromatography technology	Castello A (2012)	1
TP53	0	MOV10	6	affinity chromatography technology	Li X (2015)	1
MOV10	6	DDX42	3	affinity chromatography technology	Castello A (2012)	1
KAT8	2	TP53	0	enzymatic study, enzymatic study, pull down	Sykes SM (2006), Li X (2009), Dou Y (2005)	3
KANSL1	11	KANSL2	6	affinity chromatography technology	Huttlin EL (2017)	1
NXF1	0	PHF20	1	affinity chromatography technology	Castello A (2012)	1
NXF1	0	DDX42	3	affinity chromatography technology	Castello A (2012)	1
PHF20	1	KANSL2	6	affinity chromatography technology	Huttlin EL (2017)	1
KAT8	2	MCRS1	1	affinity chromatography technology	Sharma GG (2010)	1
TP53	0	WDR5	2	pull down, pull down	Dou Y (2005), Tang Z (2013)	2
KAT8	2	HIST1H3A	3	enzymatic study, affinity chromatography technology	Smith ER (2005), Zippo A (2009)	2