PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FOXA1	2	ESR1	0	affinity chromatography technology, imaging technique	Jozwik KM (2016), Toska E (2017)	2
CCDC120	1	MEIS1	0	affinity chromatography technology	Huttlin EL (2017)	1
SMARCD3	0	PBX1	9	pull down	Debril MB (2004)	1
CREBBP	29	HDAC3	5	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chuang HC (2006), Chuang HC (2006), Chuang HC (2006), Chuang HC (2006)	4
NR3C1	2	CREBBP	29	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Almloef T (1998), Almloef T (1998), Fryer CJ (1998), Govindan MV (2010), Govindan MV (2010), Govindan MV (2010), Carruthers CW (2015)	7
TRAF1	0	PBX1	9	affinity chromatography technology	Greenfeld H (2015)	1
MAB21L1	0	MEIS2	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FAM222A	2	PBX1	9	affinity chromatography technology	Huttlin EL (2017)	1
MAB21L1	0	PBX1	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC1	4	ESR1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Kawai H (2003), Kawai H (2003), Varshochi R (2005), Varshochi R (2005), Kurtev V (2004), Liu XF (2004), Itoh Y (2007), Tarallo R (2011), Yoshimaru T (2013)	9
C5orf24	0	MEIS1	0	affinity chromatography technology	Huttlin EL (2017)	1
MAB21L2	1	MEIS2	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC1	4	SIN3B	5	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (1999), Koipally J (1999), Romm E (2005), Humphrey GW (2001), Terhune SS (2010), Joshi P (2013), Wan C (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	10
C16orf71	1	PBX1	9	affinity chromatography technology	Huttlin EL (2017)	1
CREBBP	29	HOXB7	2	pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Chariot A (1999), Chariot A (1999), Shen WF (2001), Shen WF (2001), Shen WF (2001)	5
ESR1	0	PBX1	9	imaging technique	Toska E (2017)	1
NR3C1	2	PBX1	9	affinity chromatography technology	Subramaniam N (2003)	1
PBX1	9	HOXB7	2	two hybrid, pull down	Chang CP (1995), Chang CP (1995)	2
HDAC1	4	POU2F1	5	affinity chromatography technology, affinity chromatography technology, imaging technique	Wang P (2009), Wang P (2009), Wang P (2009)	3
FOXC1	0	C5orf24	0	affinity chromatography technology	Li X (2015)	1
LMX1B	1	MEIS1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POU2F1	5	ESR1	0	pull down	Prefontaine GG (1999)	1
PBX1	9	3211	0	pull down, x-ray crystallography	Berthelsen J (1998), Piper DE (1999)	2
PBX1	9	MDM2	2	pull down, enzymatic study	Holmlund T (2012), Holmlund T (2012)	2
PBX1	9	PDX1	2	pull down	Liu Y (2001)	1
PBX1	9	PKNOX1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Berthelsen J (1998), Huttlin EL (2015), Xu X (2016), Xu X (2016), Huttlin EL (2017), Ferretti E (2000)	6
CCDC120	1	PKNOX1	1	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	CREBBP	29	affinity chromatography technology	Abdelmohsen K (2009)	1
CREBBP	29	MDM2	2	affinity chromatography technology, enzymatic study, affinity chromatography technology	Inoue Y (2011), Wang X (2004), Sanchez M (2012)	3
LMX1B	1	MEIS2	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NEDD4L	3	PBX1	9	two hybrid	Araki N (2009)	1
VWA5A	2	PBX1	9	affinity chromatography technology	Huttlin EL (2017)	1
RBPJ	1	HOXA10	1	affinity chromatography technology	Li X (2015)	1
ESR1	0	CREBBP	29	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Sheppard HM (2001), Fan S (2002), Fan S (2002), Fan S (2002), Jin W (2008), Jaber BM (2004), Jaber BM (2004), Heery DM (1997), Ku TK (2007), Crowe DL (2006)	10
C16orf71	1	MEIS2	7	affinity chromatography technology	Huttlin EL (2017)	1
MEIS1	0	HOXD9	1	pull down	Shanmugam K (1999)	1
FAM222A	2	MEIS1	0	affinity chromatography technology	Huttlin EL (2017)	1
FOXE1	2	PBX1	9	affinity chromatography technology	Li X (2015)	1
MDM2	2	SMARCA4	19	unspecified method	Nicholson J (2014)	1
TRAF1	0	CCDC120	1	two hybrid	Rolland T (2014)	1
HDAC1	4	PBX1	9	affinity chromatography technology, affinity chromatography technology	Saleh M (2000), Saleh M (2000)	2
LMX1B	1	MAB21L1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FAM222A	2	MEIS2	7	affinity chromatography technology	Huttlin EL (2017)	1
PBX1	9	HOXC8	0	affinity chromatography technology	Kikugawa T (2006)	1
PBX1	9	HOXD9	1	pull down	Shanmugam K (1999)	1
CREBBP	29	PBX1	9	pull down	Shen WF (2001)	1
MAGEA1	0	PBX1	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FOXE1	2	HOXA10	1	affinity chromatography technology	Li X (2015)	1
MAB21L2	1	MEIS1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MEIS1	0	PBX1	9	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Shen WF (1999), Shanmugam K (1999), Jacobs Y (1999), Argiropoulos B (2010), Argiropoulos B (2010)	5
ELAVL1	0	NEDD4L	3	affinity chromatography technology	Abdelmohsen K (2009)	1
SMARCD3	0	ESR1	0	pull down	Flajollet S (2007)	1
ESR1	0	MYOD1	0	affinity chromatography technology, affinity chromatography technology	Jin W (2008), Jin W (2008)	2
NR3C1	2	MDM2	2	affinity chromatography technology	Sengupta S (2001)	1
C16orf71	1	MEIS1	0	affinity chromatography technology	Huttlin EL (2017)	1
MAB21L1	0	MEIS1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMARCA4	19	PBX1	9	affinity chromatography technology	de la Serna IL (2005)	1
HDAC3	5	SMARCA4	19	affinity chromatography technology, affinity chromatography technology	Qiu Z (2008), Zhu P (2006)	2
ELAVL1	0	NR3C1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
FOXA1	2	PBX1	9	affinity chromatography technology	Li X (2015)	1
SMARCD3	0	SMARCA4	19	affinity chromatography technology, imaging technique, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Forcales SV (2012), Forcales SV (2012), Forcales SV (2012), Havugimana PC (2012), Debril MB (2004), Wan C (2015)	6
POU2F1	5	PBX1	9	pull down	Rave-Harel N (2004)	1
FOXC1	0	POU2F1	5	affinity chromatography technology	Li X (2015)	1
CCDC120	1	PBX1	9	affinity chromatography technology	Huttlin EL (2017)	1
SIN3B	5	SMARCA4	19	pull down	Pal S (2003)	1
RBPJ	1	KAT2A	1	two hybrid	Kurooka H (2000)	1
ELAVL1	0	FOXA1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
MYOD1	0	PBX1	9	affinity chromatography technology	Philipot O (2010)	1
C5orf24	0	PBX1	9	affinity chromatography technology	Huttlin EL (2017)	1
FOXC1	0	PBX1	9	affinity chromatography technology	Li X (2015)	1
SMARCD3	0	MYOD1	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Forcales SV (2012), Forcales SV (2012), Forcales SV (2012)	3
CREBBP	29	HOXA9	0	pull down	Shen WF (2001)	1
HDAC1	4	MDM2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Ito A (2002), Ito A (2002), Gaughan L (2005), Gaughan L (2005)	5
HNRNPL	3	MYH10	9	affinity chromatography technology	Fei T (2017)	1
SMARCA4	19	CREBBP	29	genetic interference	DiRenzo J (2000)	1
CREBBP	29	MYOD1	0	affinity chromatography technology, pull down, genetic interference, pull down, enzymatic study, enzymatic study	Polesskaya A (2001), Polesskaya A (2001), Sartorelli V (1997), Sartorelli V (1997), Polesskaya A (2000), Col E (2002)	6
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
HDAC3	5	PBX1	9	affinity chromatography technology	Saleh M (2000)	1
FOXE1	2	HNRNPL	3	affinity chromatography technology	Li X (2015)	1
SMARCA4	19	RBPJ	1	affinity chromatography technology	Yatim A (2012)	1
FOXE1	2	SMARCA4	19	affinity chromatography technology	Li X (2015)	1
CREBBP	29	HOXA10	1	pull down	Shen WF (2001)	1
FOXC1	0	MEIS1	0	affinity chromatography technology	Li X (2015)	1
FAM222A	2	MAB21L1	0	affinity chromatography technology	Huttlin EL (2017)	1
HDAC1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mayanil CS (2006), Chuang HC (2006), Chuang HC (2006)	3
POU2F1	5	PKNOX1	1	pull down	Rave-Harel N (2004)	1
VWA5A	2	PKNOX1	1	affinity chromatography technology	Huttlin EL (2017)	1
PBX1	9	HOXD4	2	pull down	Shanmugam K (1999)	1
MAB21L2	1	PBX1	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FOXQ1	0	PBX1	9	affinity chromatography technology	Li X (2015)	1
HNRNPL	3	PBX1	9	affinity chromatography technology	Fei T (2017)	1
PBX1	9	SIN3B	5	affinity chromatography technology	Saleh M (2000)	1
HDAC1	4	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Qiu Z (2008), Battaglioli E (2002), Hang CT (2010), DiRenzo J (2000)	4
HOXB8	0	PBX1	9	pull down	Knoepfler PS (2001)	1
MAGEA1	0	HDAC1	4	pull down	Laduron S (2004)	1
HOXA10	1	PBX1	9	pull down	Lu Y (2003)	1
PBX1	9	KAT2A	1	affinity chromatography technology, pull down	Holmlund T (2012), Holmlund T (2012)	2
MEIS1	0	HOXA9	0	pull down, pull down, affinity chromatography technology	Shen WF (1997), Shen WF (1999), Shen WF (1999)	3
ESR1	0	MDM2	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down	Liu G (2000), Kinyamu HK (2003), Duong V (2007), Duong V (2007), Duong V (2007), Duong V (2007), Saji S (2001), Saji S (2001)	8
HDAC1	4	MYOD1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Puri PL (2001), Puri PL (2001), Mal A (2001), Bruscoli S (2010)	4
C5orf24	0	PKNOX1	1	affinity chromatography technology	Huttlin EL (2017)	1
HDAC3	5	ESR1	0	imaging technique, affinity chromatography technology, pull down, affinity chromatography technology	Liu XF (2004), Zhu P (2006), Nalvarte I (2010), Han SJ (2016)	4
RBPJ	1	PBX1	9	affinity chromatography technology	Li X (2015)	1
MEIS1	0	CREBBP	29	affinity chromatography technology	Wang Z (2010)	1
LMX1B	1	PBX1	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCDC120	1	MEIS2	7	affinity chromatography technology	Huttlin EL (2017)	1
MYH10	9	PBX1	9	affinity chromatography technology	Huang H (2003)	1
MEIS2	7	PBX1	9	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Ravasi T (2010), Liu Y (2001), Huttlin EL (2015), Huttlin EL (2017)	4
NEDD4L	3	NR3C1	2	pull down	Almloef T (1998)	1
NR3C1	2	HDAC1	4	affinity chromatography technology, affinity chromatography technology, biochemical, fluorescent resonance energy transfe, pull down	Qiu Y (2006), Jee YK (2005), Kristensen AR (2012), Qiu Y (2011), Qiu Y (2011)	5
POU2F1	5	NR3C1	2	pull down, pull down, pull down, affinity chromatography technology	Prefontaine GG (1999), Wang JM (1999), Prefontaine GG (1998), Prefontaine GG (1998)	4
NR3C1	2	3211	0	affinity chromatography technology	Subramaniam N (2003)	1
ELAVL1	0	RBPJ	1	affinity chromatography technology	Abdelmohsen K (2009)	1
HNRNPL	3	CREBBP	29	affinity chromatography technology	Fei T (2017)	1
TRAF1	0	PKNOX1	1	affinity chromatography technology	Huttlin EL (2017)	1
MYOD1	0	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Philipot O (2010), de la Serna IL (2005), Forcales SV (2012)	3
MEIS2	7	MEIS1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ESR1	0	SIN3B	5	affinity chromatography technology	Zhu P (2006)	1
HNRNPL	3	NEDD4L	3	affinity chromatography technology	Fei T (2017)	1
ELAVL1	0	PBX1	9	affinity chromatography technology	Abdelmohsen K (2009)	1
PBX1	9	UCHL3	1	biochemical	Havugimana PC (2012)	1
NR3C1	2	SMARCA4	19	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, bioid	Hsiao PW (2003), Wallberg AE (2000), Reyes JC (1997), Xu R (2007), Lempiaeinen JK (2017)	5
HOXA9	0	PBX1	9	pull down	Shen WF (1999)	1
CREBBP	29	HOXD4	2	pull down	Shen WF (2001)	1
ELAVL1	0	FOXC1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SMARCA4	19	ESR1	0	two hybrid, pull down	Ichinose H (1997), DiRenzo J (2000)	2
ESR1	0	HOXD9	1	affinity chromatography technology	Han SJ (2016)	1