PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKCA	7	OGG1	0	affinity chromatography technology, enzymatic study	Dantzer F (2002), Dantzer F (2002)	2
ERCC6	6	OGG1	0	affinity chromatography technology	Kamenisch Y (2010)	1
OGG1	0	SNRPF	0	affinity chromatography technology	Ewing RM (2007)	1
OGG1	0	7515	0	pull down, two hybrid	Marsin S (2003), Marsin S (2003)	2
ERCC6	6	ERCC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study	Anindya R (2010), Fousteri M (2006), Henning KA (1995), Latini P (2011), Latini P (2011), Fei J (2012), He J (2016), Groisman R (2006), Groisman R (2006), Groisman R (2006)	10
ERCC8	1	OGG1	0	affinity chromatography technology	Kamenisch Y (2010)	1
APLNR	1	OGG1	0	affinity chromatography technology	Huttlin EL (2017)	1
OGG1	0	CHGB	3	two hybrid	Stelzl U (2005)	1