Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
NTRK2 4915 CORTICOTROPIN CHEMBL1201610 NCI 11360665
NTRK2 4915 CYCLOSPORINE CHEMBL160 NCI 11516824
NTRK2 4915 AZD-6918 CHEMBL3545298 inhibitor ChemblInteractions
NTRK2 4915 CEP-11981 CHEMBL2010872 inhibitor GuideToPharmacologyInteractions
NTRK2 4915 ENTRECTINIB CHEMBL1983268 OncoKB 26216294, 28183697
NTRK2 4915 LOXO-101 CHEMBL3545075 inhibitor ChemblInteractions
NTRK2 4915 LESTAURTINIB CHEMBL603469 inhibitor TdgClinicalTrial, ChemblInteractions
NTRK2 4915 PLX-7486 CHEMBL3545381 inhibitor ChemblInteractions
NTRK2 4915 CEP-2563 CHEMBL3545332 inhibitor ChemblInteractions
NTRK2 4915 ALTIRATINIB CHEMBL3545365 inhibitor ChemblInteractions
NTRK2 4915 CHEMBL2007421 CHEMBL2007421 inhibitor GuideToPharmacologyInteractions
NTRK2 4915 MK-2461 CHEMBL1822792 inhibitor GuideToPharmacologyInteractions
NTRK2 4915 DOXORUBICIN CHEMBL53463 NCI 12438277
NTRK2 4915 LITHIUM CHEMBL2146126 NCI 16300803
NTRK2 4915 AZD-7451 CHEMBL3545179 inhibitor ChemblInteractions
NTRK2 4915 DITIOCARB CHEMBL961 NCI 17052849
NTRK2 4915 PILOCARPINE CHEMBL550 NCI 15183516

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
NTRK2 rs2289658 CC + CT methadone dosage no This association was statistically significant after permutation analysis based on 40,000 replicates, but not statistically significant after adjusting for testing for multiple SNPs (Bonferroni correction). Genotypes CC + CT are associated with increased dose of methadone in people with Heroin Dependence as compared to genotype TT. 23651024 982032363
NTRK2 rs1187326 C lithium efficacy not stated This is from a review article which does not give all the details. It says that no association was found between the SNP and lithium response, but it does not state exactly how the alleles were compared. Allele C is not associated with response to lithium in people with Bipolar Disorder as compared to allele T. 21047205 699639273
NTRK2 rs2289656 A lithium efficacy not stated This is from a review article which does not give all the details. It says that no association was found between the SNP and lithium response, but it does not state exactly how the alleles were compared. Allele A is not associated with response to lithium in people with Bipolar Disorder as compared to allele G. 21047205 699639275
NTRK2 rs1387923 AA lithium efficacy no Genotype AA is not associated with response to lithium in people with Bipolar Disorder as compared to genotypes AG + GG. 23315174 981954249
NTRK2 rs2120266 AA methadone dosage no This association was not statistically significant after permutation analysis based on 40,000 replicates, and not statistically significant after adjusting for testing for multiple SNPs (Bonferroni correction). Genotype AA is associated with increased dose of methadone in people with Heroin Dependence as compared to genotypes AG + GG. 23651024 982032312
NTRK2 rs4877900 CC methadone dosage no This association was not statistically significant after permutation analysis based on 40,000 replicates, and not statistically significant after adjusting for testing for multiple SNPs (Bonferroni correction). Note; this SNP was in LD with rs4358872, rs1948308, and rs2378676 (r^2>0.7). Genotype CC is associated with decreased dose of methadone in people with Heroin Dependence as compared to genotypes CT + TT. 23651024 982032504
NTRK2 rs10465180 CC clozapine efficacy yes The association remained significant after permutation. Genotype CC is associated with decreased response to clozapine in people with Schizophrenia as compared to genotypes CT + TT. 25751398 1444699432
NTRK2 rs1778929 TT clozapine efficacy no The association did not remain significant after permutation. Only the G-T-C haplotype composed of rs1619120-rs1778929-rs10465180 was associated with poor response. Genotype TT is associated with decreased response to clozapine in people with Schizophrenia as compared to genotypes CC + CT. 25751398 1444699419
NTRK2 rs1187352 C antidepressants efficacy no Alleles for this variant are shown as G and A in the tables even though gene on plus strand, but alleles available from dbSNP for annotation tool were C and T. Allele C is not associated with response to antidepressants in people with Depressive Disorder, Major as compared to allele T. 28244805 1448603809
NTRK2 rs1439050 G antidepressants efficacy no Allele G is not associated with response to antidepressants in people with Depressive Disorder, Major as compared to allele T. 28244805 1448603797
NTRK2 rs2289657 A antidepressants efficacy no Alleles for this variant are shown as G and T in the tables even though gene on plus strand, but alleles available from dbSNP for annotation tool were C and A. Allele A is not associated with response to antidepressants in people with Depressive Disorder, Major as compared to allele C. 28244805 1448603878
NTRK2 rs2289656 G antidepressants efficacy no Alleles for this variant are shown as C and T in the tables even though gene on plus strand, but alleles available from dbSNP for annotation tool were G and A. Allele G is not associated with response to antidepressants in people with Depressive Disorder, Major as compared to allele A. 28244805 1448603895
NTRK2 rs3824519 C antidepressants efficacy no Allele C is not associated with response to antidepressants in people with Depressive Disorder, Major as compared to allele T. 28244805 1448603909
NTRK2 rs1778933 C antidepressants efficacy no Allele C is not associated with response to antidepressants in people with Depressive Disorder, Major as compared to allele T. 28244805 1448603822
NTRK2 rs1187327 C lithium efficacy not stated This is from a review article which does not give all the details. It says that no association was found between the SNP and lithium response, but it does not state exactly how the alleles were compared. Allele C is not associated with response to lithium in people with Bipolar Disorder as compared to allele T. 21047205 699639277
NTRK2 rs1387923 AA lithium efficacy not stated This is from a review article which does not give all the details. It does not state exactly how the alleles were compared. Genotype AA is associated with increased response to lithium in people with Bipolar Disorder. 21047205 699639271
NTRK2 rs1565445 AA lithium efficacy no Genotype AA is not associated with response to lithium or valproic acid in people with Bipolar Disorder as compared to genotypes AG + GG. 23315174 981954223
NTRK2 rs1948308 GG methadone dosage no This association was statistically significant after permutation analysis based on 40,000 replicates, but not statistically significant after adjusting for testing for multiple SNPs (Bonferroni correction). Note; this SNP was in LD with rs4358872, rs2378676, and rs4877900 (r^2>0.7). Genotype GG is associated with decreased dose of methadone in people with Heroin Dependence as compared to genotypes AA + AG. 23651024 982032460
NTRK2 rs2289658 C antidepressants efficacy no Alleles for this variant are shown as G and A in the tables even though gene on plus strand, but alleles available from dbSNP for annotation tool were C and T. Allele C is not associated with response to antidepressants in people with Depressive Disorder, Major as compared to allele T. 28244805 1448603851
NTRK2 rs2378676 AA methadone dosage no This association was statistically significant after permutation analysis based on 40,000 replicates, but not statistically significant after adjusting for testing for multiple SNPs (Bonferroni correction). Note; this SNP was in LD with rs4358872, rs1948308, and rs4877900 (r^2>0.7). Alleles were reported as T/G, here they are complemented with A representing T and C representing G. Genotype AA is associated with decreased dose of methadone in people with Heroin Dependence as compared to genotypes AC + CC. 23651024 982032487
NTRK2 rs4358872 GG methadone dosage no This association was statistically significant after permutation analysis based on 40,000 replicates, but not statistically significant after adjusting for testing for multiple SNPs (Bonferroni correction). Note; this SNP was in LD with rs1948308, rs2378676, and rs4877900 (r^2>0.7). Genotype GG is associated with decreased dose of methadone in people with Heroin Dependence as compared to genotypes GT + TT. 23651024 982032418