PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SLC11A2	2	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Howitt J (2009), Howitt J (2009)	2
KRAS	1	SLC11A2	2	genetic interference	Luo J (2009)	1
SLC11A2	2	NDFIP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Foot NJ (2008), Howitt J (2009), Howitt J (2009)	3
NDFIP1	0	NEDD4	2	affinity chromatography technology	Xing LF (2016)	1
VPS35	2	SLC11A2	2	pull down	Harrison MS (2014)	1
SLC11A2	2	PRKN	1	affinity chromatography technology, imaging technique	Roth JA (2010), Roth JA (2010)	2
SLC11A2	2	NDFIP2	2	affinity chromatography technology	Foot NJ (2008)	1
TCTN3	2	SLC11A2	2	bioid	Gupta GD (2015)	1
NDFIP2	2	NEDD4	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology	Cristillo AD (2003), Cristillo AD (2003), Shearwin-Whyatt LM (2004), Woelk T (2006), Ohzono C (2010), Persaud A (2009), Persaud A (2009), Konstas AA (2002)	8