PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAFG	1	NFE2	0	pull down	Blank V (1997)	1
CREBBP	29	NFE2L2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Katoh Y (2001), Katoh Y (2001), Katoh Y (2001), Liu GH (2008), Liu GH (2008), Sun Z (2009), Sun Z (2009), Sun Z (2009)	8
NFE2L2	1	MAFG	1	imaging technique, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, affinity chromatography technology	Ramani K (2012), Ramani K (2012), Reinke AW (2013), Reinke AW (2013), Wang J (2011), Wu T (2013), Okita Y (2013)	7
NFE2L2	1	NFE2	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
NFE2	0	SSX5	1	two hybrid	Ravasi T (2010)	1
MAPK8	3	NFE2	0	enzymatic study	Lee TL (2010)	1
NFE2	0	BTRC	1	two hybrid	Rolland T (2014)	1
NFE2	0	TXN	1	two hybrid	Wang J (2011)	1
NFE2	0	SCAND1	1	two hybrid	Ravasi T (2010)	1
MAPK8	3	SCAND1	1	two hybrid	Vinayagam A (2011)	1
NFE2L2	1	MAPK8	3	affinity chromatography technology	Qin S (2014)	1
ELF5	0	NFE2	0	two hybrid	Ravasi T (2010)	1
MAPK8	3	ITCH	1	enzymatic study, affinity chromatography technology	Gallagher E (2006), Gallagher E (2006)	2
ATF4	2	KAT2B	2	pull down	Cherasse Y (2007)	1
YAP1	0	ITCH	1	affinity chromatography technology	Levy D (2007)	1
YAP1	0	BTRC	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhao B (2010), Zhao B (2010), Vinayagam A (2011), Huttlin EL (2017)	4
BTRC	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Liu J (2014), Liu J (2014)	2
HMGN1	0	NFE2	0	two hybrid	Ravasi T (2010)	1
NFE2L2	1	ATF4	2	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
NFE2L3	6	MAFG	1	fluorescent resonance energy transfe, affinity chromatography technology	Reinke AW (2013), Huttlin EL (2017)	2
ITCH	1	NFE2	0	enzymatic study, affinity chromatography technology, two hybrid, far western blotting	Lee TL (2008), Lee TL (2008), Chen X (2001), Chen X (2001)	4
NFE2	0	NFE2	0	pull down, fluorescent resonance energy transfe	Hung HL (2001), Reinke AW (2013)	2
NFE2	0	NEDD4	2	two hybrid	Gavva NR (1997)	1
BTRC	1	NFE2L2	1	affinity chromatography technology, bioid	Loveless TB (2015), Coyaud E (2015)	2
NFE2L3	6	NFE2L2	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
ATF4	2	CREBBP	29	pull down, affinity chromatography technology, imaging technique	Liang G (1997), Venza I (2001), Chen TC (2014)	3
CREBBP	29	KAT2B	2	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Tini M (2002), Cho H (1998), Cho H (1998), Cho H (1998), Korzus E (1998), Korzus E (1998), Korzus E (1998), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996)	10
NFE2L3	6	NFE2	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
KAT2B	2	NFE2	0	enzymatic study	Patel JH (2004)	1
BTRC	1	ATF4	2	affinity chromatography technology, two hybrid, affinity chromatography technology, x-ray crystallography, unspecified method, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Lassot I (2005), Lassot I (2001), Lassot I (2001), Evrard-Todeschi N (2008), Pons J (2008), Wang J (2011), Rolland T (2014), Loveless TB (2015), Loveless TB (2015), Yu H (2011)	10
NFE2	0	ATF4	2	fluorescent resonance energy transfe	Reinke AW (2013)	1
NFE2	0	CREBBP	29	pull down, affinity chromatography technology, enzymatic study	Hung HL (2001), Hung HL (2001), Hung HL (2001)	3
NFE2	0	YAP1	0	far western blotting, two hybrid	Gavva NR (1997), Gavva NR (1997)	2