PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAPK3	4	MYOG	1	two hybrid	Corominas R (2014)	1
CARM1	0	MYOG	1	pull down	Dacwag CS (2009)	1
SP1	0	SMARCA4	19	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kadam S (2000), Liu H (2002), Liu H (2002), Ma Z (2004), Saladi SV (2010)	5
CARM1	0	SMARCA4	19	biochemical, affinity chromatography technology, pull down, far western blotting	Xu W (2004), Xu W (2004), Xu W (2004), Xu W (2004)	4
SRF	1	MYOG	1	pull down, pull down	Groisman R (1996), Biesiada E (1999)	2
MYOG	1	TCF4	26	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CSRP3	1	MYOG	1	pull down	Kong Y (1997)	1
TCF4	26	ID4	1	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
TCF4	26	TCF3	7	two hybrid, affinity chromatography technology	Ravasi T (2010), Huttlin EL (2017)	2
MLH1	6	MYOG	1	two hybrid	Rolland T (2014)	1
MYOG	1	NES	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMARCA4	19	MYOG	1	imaging technique, affinity chromatography technology	Ohkawa Y (2006), Ohkawa Y (2006)	2
SEPT5	1	MYOG	1	two hybrid	Corominas R (2014)	1
TCF3	7	ID4	1	affinity chromatography technology	Teachenor R (2012)	1
MYOG	1	HYPM	0	two hybrid	Rolland T (2014)	1
CDH18	5	MYOG	1	two hybrid	Wang J (2011)	1
TCF4	26	TCF12	14	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
MYOG	1	IKBIP	2	two hybrid	Rolland T (2014)	1
PRMT5	3	MYOG	1	pull down	Dacwag CS (2009)	1
MDFI	1	TTC25	0	two hybrid	Yu H (2011)	1
MEF2C	16	MYOG	1	pull down	Molkentin JD (1995)	1
POLR2C	0	PRMT5	3	affinity chromatography technology	Ayguen O (2008)	1
SP1	0	SRF	1	pull down	Biesiada E (1999)	1
MYOG	1	MEF2A	1	pull down	Funk WD (1992)	1
EIF4E2	2	MDFI	1	two hybrid	Venkatesan K (2009)	1
MEF2C	16	SP1	0	two hybrid, affinity chromatography technology	Krainc D (1998), Krainc D (1998)	2
TCF4	26	EIF4E2	2	two hybrid	Rolland T (2014)	1
MYOG	1	ID4	1	affinity chromatography technology	Huttlin EL (2017)	1
MYOG	1	TXNDC9	0	two hybrid	Rolland T (2014)	1
PRMT5	3	CARM1	0	genetic interference	Wong AS (2016)	1
TCF3	7	PRMT5	3	affinity chromatography technology	Teachenor R (2012)	1
MDFI	1	MYOG	1	two hybrid, pull down	Chen CM (1996), Chen CM (1996)	2
POLR2C	0	MYOG	1	two hybrid, pull down, pull down, affinity chromatography technology	Corbi N (2002), Corbi N (2002), Corbi N (2002), Corbi N (2002)	4
MYOG	1	CCDC28A	0	two hybrid	Rolland T (2014)	1
TCF12	14	TCF3	7	affinity chromatography technology	Yoon SJ (2011)	1
TCF4	26	NES	2	affinity chromatography technology	Huttlin EL (2017)	1
MYOG	1	TCF12	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MYOG	1	PACRGL	1	two hybrid	Rolland T (2014)	1
FBXO7	1	MYOG	1	enzymatic study	Teixeira FR (2016)	1
SMARCA4	19	SRF	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhou J (2009), Zhou J (2009), Zhang M (2007)	3
MYOG	1	EIF4E2	2	two hybrid	Rolland T (2014)	1
SMARCA4	19	PRMT5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Pal S (2003), Pal S (2003), Pal S (2003), Pal S (2003), Pal S (2003), Aggarwal P (2010)	6
MYOG	1	TTC25	0	two hybrid	Rolland T (2014)	1
MYOG	1	CLUAP1	1	two hybrid	Rolland T (2014)	1
TCF3	7	MYOG	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Langlands K (1997), Chakraborty T (1992), Huttlin EL (2015), Brennan TJ (1990), Huttlin EL (2017)	5
FTL	0	MYOG	1	two hybrid	Rolland T (2014)	1
SP1	0	MYOG	1	pull down, pull down	Biesiada E (1999), Biesiada E (1999)	2
MYOG	1	TRIM43	0	two hybrid	Wang J (2011)	1
MYOG	1	TAF6L	3	two hybrid	Wang J (2011)	1
MYOG	1	HNF1A	0	pull down	Funk WD (1992)	1
TTC25	0	YME1L1	2	affinity chromatography technology	Huttlin EL (2017)	1
MYOG	1	YME1L1	2	two hybrid	Wang J (2011)	1
MAPK3	4	SP1	0	enzymatic study, enzymatic study	Milanini-Mongiat J (2002), Cramer T (2008)	2
BBS4	2	MYOG	1	two hybrid	Rolland T (2014)	1
TTC32	0	MYOG	1	two hybrid	Yu H (2011)	1
MEF2A	1	MEF2C	16	affinity chromatography technology	Li X (2015)	1