PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SP1	0	TBP	0	two hybrid, two hybrid, pull down, pull down	Loregian A (2003), Loregian A (2003), Schwarzenbach H (2014), Schwarzenbach H (2014)	4
DLX2	0	MSX2	1	pull down, pull down	Zhang H (1997), Zhang H (1997)	2
MSX2	1	TLE2	4	two hybrid	Ravasi T (2010)	1
TBP	0	CREBBP	29	affinity chromatography technology	Dallas PB (1997)	1
MSX1	0	CREBBP	29	genetic interference, affinity chromatography technology	Shetty S (1999), Shetty S (1999)	2
MSX1	0	LHX2	0	pull down	Bendall AJ (1998)	1
MSX1	0	TBP	0	genetic interference, affinity chromatography technology, pull down, pull down	Shetty S (1999), Shetty S (1999), Zhang H (1997), Zhang H (1996)	4
MSX1	0	HOXC8	0	pull down	Zhang H (1997)	1
MSX2	1	MSX1	0	pull down, pull down, two hybrid	Zhang H (1997), Zhang H (1997), Zhang H (1997)	3
MSX1	0	NMNAT1	0	two hybrid	Wang J (2011)	1
CREBBP	29	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goto T (2006), Leclerc GJ (2010), Chuang JY (2012), Guo W (2014)	4
MSX1	0	SP1	0	genetic interference, affinity chromatography technology	Shetty S (1999), Shetty S (1999)	2
DLX5	0	MSX2	1	pull down, pull down	Zhang H (1997), Zhang H (1997)	2
DLX2	0	HOXC8	0	pull down	Zhang H (1997)	1
DLX5	0	DLX2	0	pull down, pull down	Zhang H (1997), Zhang H (1997)	2
DLX2	0	MSX1	0	pull down, pull down, two hybrid	Zhang H (1997), Zhang H (1997), Zhang H (1997)	3
TBP	0	PAX3	6	pull down	Cvekl A (1999)	1
ING4	1	MSX1	0	two hybrid	Wang J (2011)	1
PAX3	6	MSX1	0	pull down	Bendall AJ (1999)	1
MED19	1	MSX1	0	two hybrid	Wang J (2011)	1
MSX1	0	MSX1	0	pull down, two hybrid	Zhang H (1997), Zhang H (1997)	2
MSX1	0	TLE2	4	two hybrid	Ravasi T (2010)	1
DLX5	0	MSX1	0	pull down, pull down	Zhang H (1997), Zhang H (1997)	2
DLX5	0	HOXC8	0	pull down	Zhang H (1997)	1