PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HCFC1	4	ASCL2	0	affinity chromatography technology	Wysocka J (2003)	1
RBBP5	3	KMT2C	28	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Goo YH (2003), Goo YH (2003), Cho YW (2007), Shinsky SA (2015), Alicea-Velazquez NL (2016)	5
RBBP5	3	ASCL2	0	biochemical, affinity chromatography technology	Goo YH (2003), Goo YH (2003)	2
NCOA6	6	ASCL2	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Goo YH (2003), Goo YH (2003), Goo YH (2003), Goo YH (2003)	4
EP300	36	ASCL2	0	affinity chromatography technology	Sengupta S (2011)	1
NCOA6	6	TUBA1A	13	biochemical, affinity chromatography technology	Goo YH (2003), Goo YH (2003)	2
NCOA6	6	HCFC1	4	affinity chromatography technology	Tang Z (2013)	1
HCFC1	4	RBBP5	3	biochemical, affinity chromatography technology, biochemical	Yokoyama A (2004), Mak AB (2010), Havugimana PC (2012)	3
APEX1	1	ASCL2	0	affinity chromatography technology	Sengupta S (2011)	1
NCOA6	6	EP300	36	affinity chromatography technology, pull down	Ko L (2000), Ko L (2000)	2
EP300	36	RBBP5	3	affinity chromatography technology	Tang Z (2013)	1
RBBP5	3	TUBA1A	13	biochemical	Goo YH (2003)	1
NCOA6	6	RBBP5	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goo YH (2003), Goo YH (2003), Goo YH (2003), Lee J (2008), Patel SR (2007), Patel SR (2007), Cho YW (2007), Cho YW (2007), Tang Z (2013)	9
NCOA6	6	KMT2C	28	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goo YH (2003), Goo YH (2003), Goo YH (2003), Lee J (2008), Lee S (2006)	5
ASCL2	0	TUBA1A	13	affinity chromatography technology	Goo YH (2003)	1
APEX1	1	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, enzymatic study, pull down	Sengupta S (2011), Sengupta S (2011), Sengupta S (2011), Sengupta S (2011), Bhakat KK (2003), Yamamori T (2010), Karmakar S (2010)	7
KMT2C	28	ASCL2	0	affinity chromatography technology	Goo YH (2003)	1