Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
ACHE 43 ECHOTHIOPHATE IODIDE CHEMBL1200367 inhibitor ChemblInteractions
ACHE 43 EDROPHONIUM CHEMBL1104 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank, TTD 10089512, 11752352, 10103097, 19472276, 10433700, 10421446, 10363282
ACHE 43 CHOLINE CHEMBL920 product of DrugBank 16302752, 16565162, 16297435, 17139155, 16456188
ACHE 43 GALLAMINE TRIETHIODIDE CHEMBL1200993 inhibitor DrugBank 11920914, 17944454, 10421444, 1207670, 417864, 3190453
ACHE 43 ISOFLUROPHATE CHEMBL1025 inhibitor ChemblInteractions, DrugBank, TTD 12837382, 10898598, 10378121, 11350858, 11752352, 1692236
ACHE 43 DEMECARIUM CHEMBL1201229 inhibitor DrugBank 11752352, 12641839
ACHE 43 AMBENONIUM CHEMBL1652 inhibitor TdgClinicalTrial, TEND, DrugBank, TTD 15982786, 11752352, 11330337, 2857786, 13679187, 5833399, 1588924
ACHE 43 TUBOCURARINE CHEMBL339427 inhibitor DrugBank 15878275, 11920914, 11823003, 10421444, 1475066
ACHE 43 HUPERZINE B CHEMBL245079 DrugBank 17126020, 10592235
ACHE 43 CHEMBL257591 CHEMBL257591 DrugBank 17139284, 17016423, 10592235
ACHE 43 CHEMBL107316 CHEMBL107316 DrugBank 10592235
ACHE 43 ECHOTHIOPHATE CHEMBL1201341 inhibitor GuideToPharmacologyInteractions, ChemblInteractions
ACHE 43 HEXAFLUORENIUM BROMIDE CHEMBL1200933 inhibitor ChemblInteractions
ACHE 43 RIVASTIGMINE CHEMBL636 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, TTD
ACHE 43 TACRINE HYDROCHLORIDE CHEMBL1677 inhibitor ChemblInteractions
ACHE 43 ITOPRIDE CHEMBL2107457 TdgClinicalTrial
ACHE 43 TACRINE CHEMBL95 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank 15544507, 11752352, 10513568, 10375753, 16860785, 16880719, 10210906, 15544504, 17218977, 10024872, 12871155, 10208549
ACHE 43 PHYSOSTIGMINE CHEMBL94 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank, TTD 11752352, 11141093, 10741458, 10403635, 10368402, 10873710
ACHE 43 CHEMBL117651 CHEMBL117651 DrugBank 17139284, 17016423, 10592235
ACHE 43 ZANAPEZIL CHEMBL75013 DrugBank 15951830
ACHE 43 CHEMBL153254 CHEMBL153254 DrugBank 10592235
ACHE 43 6-AMINONICOTINAMIDE CHEMBL1324108 NCI 153476
ACHE 43 PRALIDOXIME CHLORIDE CHEMBL748 activator ChemblInteractions
ACHE 43 GALANTAMINE CHEMBL659 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, TTD
ACHE 43 PYRIDOSTIGMINE CHEMBL1115 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, TTD
ACHE 43 LATREPIRDINE CHEMBL589390 TdgClinicalTrial
ACHE 43 RIVASTIGMINE TARTRATE CHEMBL215645 inhibitor ChemblInteractions
ACHE 43 PRALIDOXIME CHEMBL1420 inhibitor GuideToPharmacologyInteractions
ACHE 43 DONEPEZIL HYDROCHLORIDE CHEMBL1678 inhibitor ChemblInteractions
ACHE 43 MINAPRINE CHEMBL278819 inhibitor DrugBank 10052979, 18045214
ACHE 43 DECAMETHONIUM CHEMBL1190 inhibitor DrugBank 239236, 3190453, 2913485, 3345199, 1207670
ACHE 43 CHEMBL490866 CHEMBL490866 DrugBank 17139284, 17016423, 10592235
ACHE 43 CHEMBL483716 CHEMBL483716 DrugBank 10592235
ACHE 43 8-AZAGUANINE CHEMBL374107 NCI 1207869
ACHE 43 NEOSTIGMINE METHYLSULFATE CHEMBL211471 inhibitor ChemblInteractions
ACHE 43 EDROPHONIUM CHLORIDE CHEMBL1128 inhibitor ChemblInteractions
ACHE 43 ACOTIAMIDE CHEMBL2107723 TdgClinicalTrial
ACHE 43 AMBENONIUM CHLORIDE CHEMBL1200541 inhibitor ChemblInteractions
ACHE 43 BETAMETHASONE CHEMBL632 NCI 3896398
ACHE 43 MALATHION CHEMBL1200468 inhibitor TTD
ACHE 43 PROPIDIUM CHEMBL345124 DrugBank 17139284, 17016423, 10592235
ACHE 43 CHEMBL1082738 CHEMBL1082738 DrugBank 10592235
ACHE 43 HUPERZINE A CHEMBL1255901 TdgClinicalTrial, DrugBank 12895686, 10592235
ACHE 43 CHEMBL1235106 CHEMBL1235106 DrugBank 10592235
ACHE 43 THIOGUANINE CHEMBL727 NCI 1207869
ACHE 43 PYRIDOSTIGMINE BROMIDE CHEMBL812 inhibitor ChemblInteractions
ACHE 43 GALANTAMINE HYDROBROMIDE CHEMBL1555 inhibitor ChemblInteractions
ACHE 43 DEMECARIUM BROMIDE CHEMBL1200514 inhibitor TdgClinicalTrial, ChemblInteractions, TEND
ACHE 43 NEOSTIGMINE CHEMBL278020 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, TTD
ACHE 43 DONEPEZIL CHEMBL502 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, TTD
ACHE 43 GALACTITOL CHEMBL1773904 NCI 11098845
ACHE 43 PHENSERINE CHEMBL74926 TdgClinicalTrial, DrugBank 17594192, 16248851
ACHE 43 DIMETACRINE CHEMBL1328913 antagonist DrugBank 4539395
ACHE 43 DIPIVEFRIN CHEMBL1201262 DrugBank 8446367
ACHE 43 METHADONE CHEMBL651 NCI 8149590
ACHE 43 MAGNESIUM CHLORIDE CHEMBL2219642 NCI 8747488

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
ACHE rs2571598 TT donepezil efficacy no Response to donepezil was assessed by the mini mental state examination (MMSE) at baseline and at 1, 3, 9 and 15 months after beginning therapy. Genotype TT is not associated with response to donepezil in people with Alzheimer Disease as compared to genotypes CC + CT. 18780301 1185235091
ACHE rs2571598 TT rivastigmine efficacy yes Response to rivastimine was assessed by the mini mental state examination (MMSE) at baseline and at 1, 3, 9 and 15 months after beginning therapy. Genotype TT is associated with increased response to rivastigmine in people with Alzheimer Disease as compared to genotypes CC + CT. 18780301 1185235045
ACHE rs6942609 A donepezil efficacy yes Presented as trend test of GG, GA, and AA in responder vs non responder. Donepezil 84 patients, galantamine 52 patients, rivastigmine 22 patients. No significant differences in genotype by drug type. Patients assessed after 1 week and 4 weeks of therapy to adjust dosage and evaluate adverse events. Response rate assessed at 26 weeks of treatment. Allele A is not associated with response to donepezil, galantamine or rivastigmine in people with Alzheimer Disease as compared to allele G. 25730470 1447679317