PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MEST	2	MPZL2	0	two hybrid	Wang J (2011)	1
FBXO7	1	MEST	2	enzymatic study	Teixeira FR (2016)	1
HGS	5	ING5	3	two hybrid	Rolland T (2014)	1
MEST	2	ZNF579	2	two hybrid	Vinayagam A (2011)	1
HGS	5	APP	1	pull down, pull down, pull down	Pridgeon JW (2009), Olah J (2011), Virok DP (2011)	3
FBXO7	1	BAG6	2	affinity chromatography technology	Teixeira FR (2016)	1
MEST	2	CMTM3	0	two hybrid	Vinayagam A (2011)	1
SMYD3	0	APP	1	pull down	Olah J (2011)	1
MEST	2	DBN1	1	two hybrid	Vinayagam A (2011)	1
MEST	2	BLOC1S2	0	two hybrid	Vinayagam A (2011)	1
MEST	2	FST	0	two hybrid	Vinayagam A (2011)	1
MEST	2	APP	1	pull down	Olah J (2011)	1
MEST	2	ING5	3	two hybrid	Vinayagam A (2011)	1
MEST	2	ZNF205	1	two hybrid	Vinayagam A (2011)	1
MEST	2	ABCD3	1	affinity chromatography technology	Ewing RM (2007)	1
MEST	2	CRELD2	0	two hybrid	Vinayagam A (2011)	1
BLOC1S2	0	APP	1	pull down	Olah J (2011)	1
MEST	2	BAG6	2	two hybrid	Vinayagam A (2011)	1
MEST	2	FEZ1	0	two hybrid	Vinayagam A (2011)	1
HGS	5	MEST	2	pull down	Pridgeon JW (2009)	1
MEST	2	KIFAP3	1	two hybrid	Vinayagam A (2011)	1
SMYD3	0	MEST	2	affinity chromatography technology	Ewing RM (2007)	1
MEST	2	CEP70	1	two hybrid	Vinayagam A (2011)	1
CMTM3	0	APP	1	pull down	Olah J (2011)	1
CD300C	2	MEST	2	two hybrid	Wang J (2011)	1