PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM5	4	UBC	7	enzymatic study	Pertel T (2011)	1
TOM1L2	0	CUEDC1	4	affinity chromatography technology	Huttlin EL (2017)	1
MYO6	3	TOM1L2	0	affinity chromatography technology, two hybrid	Tumbarello DA (2012), Tumbarello DA (2012)	2
MRPL38	2	CUEDC1	4	affinity chromatography technology	Huttlin EL (2017)	1
WBP2	0	MYO6	3	two hybrid	Lim SK (2016)	1
ARRDC3	0	NEDD4L	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Shea FF (2012), Shea FF (2012), Huttlin EL (2017)	3
WBP2	0	CUEDC1	4	two hybrid	Lim SK (2016)	1
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
TRIM5	4	CUEDC1	4	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	TOM1L2	0	pull down, pull down	Nathan JA (2013), Zhang X (2017)	2
IKBKG	0	NFKBIA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Stempin CC (2011), Pringle LM (2011), Wu CJ (2006), Higashimoto T (2008), Ducut Sigala JL (2004), Shibata Y (2011), Liu L (2002), Xiao G (2000), Chan H (2005), Funakoshi-Tago M (2005), Wu X (2007), Kato T (2008), Niu J (2011), Neumann M (2011), Keusekotten K (2013), Fu J (2013), Dan HC (2008), Criollo A (2010), Hein MY (2015), Baratchian M (2016)	20
SRPRB	0	CUEDC1	4	affinity chromatography technology	Huttlin EL (2015)	1
SMURF1	4	UBC	7	affinity chromatography technology, enzymatic study, pull down	Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017)	3
NEDD4	2	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Huttlin EL (2017)	2
TMEM51	2	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMURF2	3	UBC	7	enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Maspero E (2013), Zhang L (2013), Kristariyanto YA (2015), Mari S (2014), Zhang Y (2017)	5
TRIM5	4	MAP3K1	4	affinity chromatography technology	Pertel T (2011)	1
TRIM25	5	RPL15	1	affinity chromatography technology	Choudhury NR (2017)	1
TMEM92	0	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
MAP3K1	4	TOM1L2	0	enzymatic study	Charlaftis N (2014)	1
TRIM25	5	NEDD4L	3	affinity chromatography technology	Choudhury NR (2017)	1
RPL15	1	CUEDC1	4	affinity chromatography technology	Huttlin EL (2017)	1
NEDD4L	3	CUEDC1	4	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
UBC	7	MYO6	3	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down	Matsumoto M (2005), Bish RA (2007), He F (2016), He F (2016), Zhang X (2017)	5
SMURF2	3	CUEDC1	4	two hybrid	Colland F (2004)	1
UBC	7	NEDD4L	3	x-ray crystallography, enzymatic study, enzymatic study, enzymatic study	Kamadurai HB (2009), Sheng Y (2012), Maspero E (2013), Michel MA (2015)	4
LDLRAD4	1	CUEDC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC1	4	CUEDC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	CUEDC1	4	pull down	Zhang X (2017)	1
LDLRAD4	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDLRAD4	1	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FAM189A2	2	CUEDC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TMEM92	0	CUEDC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	SRPRB	0	pull down	Zhang X (2017)	1
LDLRAD4	1	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM5	4	IKBKG	0	affinity chromatography technology	Pertel T (2011)	1
MAP3K1	4	CUEDC1	4	enzymatic study	Charlaftis N (2014)	1
IKBKG	0	CUEDC1	4	pull down	Fenner BJ (2010)	1
FAM189A2	2	FAM189B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NFKBIA	0	CUEDC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DUSP19	0	CUEDC1	4	affinity chromatography technology	Huttlin EL (2015)	1
WBP2	0	UBC	7	two hybrid	Lim SK (2016)	1
ZNF114	1	CUEDC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
OIP5	1	CUEDC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NEDD4	2	CUEDC1	4	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
TMEM92	0	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC3	0	CUEDC1	4	affinity chromatography technology	Huttlin EL (2017)	1
SMURF1	4	TOM1L2	0	enzymatic study	Andrews PS (2010)	1
FAM189A2	2	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TMEM52B	0	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TMEM52B	0	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC3	0	NEDD4	2	affinity chromatography technology, imaging technique, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Nabhan JF (2010), Nabhan JF (2010), Qi S (2014), Qi S (2014), Qi S (2014), Huttlin EL (2017)	6
FAM189B	2	CUEDC1	4	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K1	4	NFKBIA	0	enzymatic study	Tu Z (2003)	1
ARRDC1	4	NEDD4	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Rauch S (2011), Huttlin EL (2015), Huttlin EL (2017)	3
MYO6	3	CUEDC1	4	affinity chromatography technology	Huttlin EL (2017)	1
ARRDC1	4	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WBP2	0	TOM1L2	0	two hybrid	Lim SK (2016)	1
FAM189A2	2	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TMEM51	2	CUEDC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
TMEM52B	0	CUEDC1	4	affinity chromatography technology	Huttlin EL (2017)	1
SMURF1	4	CUEDC1	4	enzymatic study	Andrews PS (2010)	1
DUSP22	1	CUEDC1	4	affinity chromatography technology	Huttlin EL (2017)	1
WBP2	0	NEDD4L	3	affinity chromatography technology, two hybrid	Persaud A (2009), Lim SK (2016)	2
FAM189B	2	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
NEDD4	2	WBP2	0	enzymatic study, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study	Persaud A (2009), Persaud A (2009), Persaud A (2009), Ingham RJ (2005), Kathman SG (2015), Qiu Y (2017)	6
FAM189B	2	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDLRAD4	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NEDD4	2	TOM1L2	0	enzymatic study	Persaud A (2009)	1
TMEM51	2	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	CUEDC1	4	affinity chromatography technology	Choudhury NR (2017)	1