PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SMAD3	1	TSC22D4	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
HSPB1	2	LBP	2	two hybrid	Wang J (2011)	1
LBP	2	SMAD3	1	two hybrid	Wang J (2011)	1
CD14	3	LBP	2	pull down, biochemical	Thomas CJ (2002), Yu B (1995)	2
LBP	2	PYCR3	0	two hybrid	Wang J (2011)	1
CBFA2T2	3	LBP	2	two hybrid	Wang J (2011)	1
C4BPA	3	LBP	2	two hybrid	Wang J (2011)	1
BAG6	2	LBP	2	two hybrid	Wang J (2011)	1
CFHR1	0	PRDX4	0	two hybrid	Wang J (2011)	1
LBP	2	PSMA3	1	two hybrid	Wang J (2011)	1
HSPB1	2	FTH1	0	two hybrid, affinity chromatography technology	Katsogiannou M (2014), Katsogiannou M (2014)	2
LBP	2	TSC22D4	1	two hybrid	Wang J (2011)	1
LBP	2	TRA2A	1	two hybrid	Wang J (2011)	1
BST1	0	LBP	2	two hybrid	Wang J (2011)	1
FTH1	0	LBP	2	two hybrid	Wang J (2011)	1
LBP	2	SETD1A	12	two hybrid	Wang J (2011)	1
LBP	2	PRDX4	0	two hybrid	Wang J (2011)	1
HSPB1	2	PSMA3	1	two hybrid	Katsogiannou M (2014)	1
LBP	2	APOA1	0	affinity chromatography technology	Park CT (1996)	1
LBP	2	CFHR1	0	affinity chromatography technology	Park CT (1996)	1