Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
KCNMA1 3778 DIAZOXIDE CHEMBL181 other DrugBank 16446048, 12726817, 2541731
KCNMA1 3778 CHLORZOXAZONE CHEMBL1371 TdgClinicalTrial, TEND, DrugBank 20505091, 16859676, 10712246
KCNMA1 3778 HALOTHANE CHEMBL931 inhibitor DrugBank 10592235, 10794813
KCNMA1 3778 HYDROFLUMETHIAZIDE CHEMBL1763 DrugBank 17139284, 17016423
KCNMA1 3778 HYDROCHLOROTHIAZIDE CHEMBL435 DrugBank 14766795
KCNMA1 3778 CHEMBL1290115 CHEMBL1290115 activator GuideToPharmacologyInteractions
KCNMA1 3778 TRICHLORMETHIAZIDE CHEMBL1054 TdgClinicalTrial, TEND
KCNMA1 3778 BMS-223131 CHEMBL222460 activator ChemblInteractions
KCNMA1 3778 BENDROFLUMETHIAZIDE CHEMBL1684 inducer DrugBank 14766795
KCNMA1 3778 FLINDOKALNER CHEMBL266510 activator GuideToPharmacologyInteractions, ChemblInteractions
KCNMA1 3778 ENFLURANE CHEMBL1257 TdgClinicalTrial, TEND
KCNMA1 3778 CHLOROTHIAZIDE CHEMBL842 TEND
KCNMA1 3778 ANDOLAST CHEMBL119549 activator ChemblInteractions
KCNMA1 3778 MICONAZOLE CHEMBL91 inhibitor DrugBank 1376313, 8760033
KCNMA1 3778 PROCAINE CHEMBL569 binder DrugBank 2580269

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
KCNMA1 rs35793 G quetiapine efficacy yes as measured by changes in PANSS-T (positive and negative syndrome scale total score), using a mixed model repeated measures approach. Examined 6789 SNPs - p-value of p< or equal to 5x10-4 was considered significant. Please note: reported allele was C, this has been complemented to the plus chromosomal strand. It was unclear whether the allele was associated with an increased or decreased response to drug. Allele G is associated with response to quetiapine in people with Schizophrenia. 22920393 981238738