PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDC73	1	ARF1	1	affinity chromatography technology	Herr P (2015)	1
CLN3	2	ARF3	0	affinity chromatography technology	Scifo E (2013)	1
ELAVL1	0	CLN3	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ARF1	1	ARFIP2	0	pull down	Kanoh H (1997)	1
TRIM25	5	FAF2	4	affinity chromatography technology	Choudhury NR (2017)	1
SIRT7	1	ELAVL1	0	affinity chromatography technology	Tsai YC (2012)	1
ARF1	1	GGA3	6	two hybrid, two hybrid, two hybrid, pull down, pull down	DellAngelica EC (2000), Puertollano R (2001), Puertollano R (2001), DellAngelica EC (2000), Takatsu H (2002)	5
SIRT7	1	ARF3	0	affinity chromatography technology	Tsai YC (2012)	1
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
TRIM25	5	GGA1	0	affinity chromatography technology	Choudhury NR (2017)	1
GGA1	0	TFDP1	3	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	HNRNPA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Close P (2012), Roy R (2014), Hein MY (2015)	4
FOXA1	2	ARF3	0	affinity chromatography technology	Jozwik KM (2016)	1
SLC2A4	1	ARF3	0	affinity chromatography technology	Foster LJ (2006)	1
GGA1	0	ARF1	1	pull down, two hybrid, pull down, affinity chromatography technology	Collins BM (2003), Mattera R (2004), Takatsu H (2002), Fukaya M (2011)	4
FOXA1	2	KIF23	0	affinity chromatography technology	Jozwik KM (2016)	1
ATN1	2	ARF3	0	two hybrid	Lim J (2006)	1
TRIM25	5	BSG	1	affinity chromatography technology	Choudhury NR (2017)	1
ARFIP2	0	ARFIP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	TFDP1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
ARF3	0	ARFIP1	2	two hybrid, pull down, pull down	Kanoh H (1997), Kanoh H (1997), Williger BT (1999)	3
SIRT7	1	KIF23	0	affinity chromatography technology	Tsai YC (2012)	1
GGA1	0	GGA3	6	imaging technique, pull down, pull down	Ghosh P (2003), Ghosh P (2003), Ghosh P (2003)	3
TFDP1	3	ARF3	0	affinity chromatography technology	Hauri S (2016)	1
ELAVL1	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, pull down	Abdelmohsen K (2009), Zhou HL (2013), Zhou HL (2013)	3
ARF3	0	GGA2	2	two hybrid	Boman AL (2000)	1
ITGA4	4	HNRNPA1	1	affinity chromatography technology	Byron A (2012)	1
ELAVL1	0	FOXA1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CDC73	1	ARF3	0	affinity chromatography technology	Herr P (2015)	1
ARF3	0	ARFIP2	0	two hybrid, pull down	Kanoh H (1997), Kanoh H (1997)	2
MMS19	5	ARF1	1	affinity chromatography technology	Stehling O (2012)	1
TRIM25	5	ATN1	2	affinity chromatography technology	Choudhury NR (2017)	1
ARF1	1	ARF3	0	biochemical	Havugimana PC (2012)	1
KIF23	0	ARF3	0	two hybrid, pull down	Boman AL (1999), Boman AL (1999)	2
ITGA4	4	ARF3	0	affinity chromatography technology	Byron A (2012)	1
GGA2	2	GGA3	6	pull down, pull down	Ghosh P (2003), Ghosh P (2003)	2
MMS19	5	ARF3	0	affinity chromatography technology	Stehling O (2012)	1
TRIM25	5	HNRNPA1	1	affinity chromatography technology	Choudhury NR (2017)	1
ARF3	0	GGA1	0	two hybrid, two hybrid, pull down, pull down, pull down	Boman AL (2002), Boman AL (2000), Boman AL (2000), McKay MM (2004), Takatsu H (2002)	5
ELAVL1	0	ARF3	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SLC2A4	1	BSG	1	affinity chromatography technology	Foster LJ (2006)	1
SLC2A4	1	ARFIP1	2	affinity chromatography technology	Foster LJ (2006)	1
TRIM25	5	ARF3	0	affinity chromatography technology	Choudhury NR (2017)	1
BSG	1	ARF3	0	affinity chromatography technology	Wu B (2017)	1
FAF2	4	ARF3	0	affinity chromatography technology	Christianson JC (2012)	1
ARF3	0	GGA3	6	two hybrid, two hybrid	Boman AL (2002), Boman AL (2000)	2
GGA2	2	ARF1	1	pull down	Takatsu H (2002)	1
GGA1	0	GGA2	2	imaging technique, pull down, pull down, affinity chromatography technology	Ghosh P (2003), Ghosh P (2003), Ghosh P (2003), Huttlin EL (2017)	4
ARF1	1	ARFIP1	2	pull down	Kanoh H (1997)	1
HNRNPA1	1	ARF3	0	affinity chromatography technology	Roy R (2014)	1
ITGA4	4	ARF1	1	affinity chromatography technology	Byron A (2012)	1