PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CEP63	2	TEX9	1	bioid	Gupta GD (2015)	1
SPICE1	2	KDM1A	2	two hybrid	Weimann M (2013)	1
TEX9	1	NOL4L	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SPICE1	2	PCM1	5	affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	4
CCDC148	0	TEX9	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP128	1	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	SPICE1	2	bioid	Gupta GD (2015)	1
PCM1	5	TEX9	1	bioid	Gupta GD (2015)	1
SPICE1	2	TEX9	1	bioid	Gupta GD (2015)	1
TEX9	1	NOL4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SPICE1	2	CEP135	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP135	2	PCM1	5	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP63	2	CEP128	1	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
PCM1	5	CCDC112	4	bioid	Gupta GD (2015)	1
CEP63	2	SPICE1	2	bioid	Firat-Karalar EN (2014)	1
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CCDC112	4	TEX9	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2015), Huttlin EL (2017)	3
CEP128	1	TEX9	1	bioid	Gupta GD (2015)	1
TEX9	1	KDM1A	2	two hybrid	Weimann M (2013)	1
PCM1	5	CEP63	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP135	2	TEX9	1	bioid	Gupta GD (2015)	1
CEP128	1	CCDC112	4	bioid	Gupta GD (2015)	1