PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CLNS1A	2	ITGA2B	2	affinity chromatography technology, pull down	Larkin D (2004), Larkin D (2004)	2
ITGA2B	2	FGG	1	unspecified method	Hantgan RR (2006)	1
ITGB3	6	CIB1	2	affinity chromatography technology, affinity chromatography technology	Yamodo IH (2012), Yamodo IH (2012)	2
FN1	17	FGG	1	affinity chromatography technology	Moussavi-Harami SF (2013)	1
FGA	5	ITGB3	6	unspecified method	Wierzbicka I (1997)	1
CAMK2A	6	ITGA2B	2	enzymatic study	Hillery CA (1991)	1
FN1	17	F2	2	affinity chromatography technology	Moussavi-Harami SF (2013)	1
ITGA2B	2	COL2A1	9	pull down	Tuckwell DS (1994)	1
ITGA2B	2	F2	2	pull down	Plow EF (2001)	1
ITGB3	6	PLA2G4A	1	affinity chromatography technology, affinity chromatography technology, pull down	Prevost N (2009), Prevost N (2009), Prevost N (2009)	3
GRB2	2	FN1	17	two hybrid, affinity chromatography technology	Wang J (2008), Humphries JD (2009)	2
FBXO6	0	AUP1	0	affinity chromatography technology	Liu B (2012)	1
F2	2	FGA	5	x-ray crystallography, imaging technique	Stubbs MT (1992), Chen TC (2014)	2
ITGB3	6	FGG	1	unspecified method	Hantgan RR (2006)	1
ITGA2B	2	FN1	17	pull down	Kauf AC (2001)	1
RNF181	0	ITGA2B	2	pull down, pull down, affinity chromatography technology	Larkin D (2004), Brophy TM (2008), Brophy TM (2008)	3
FBXO6	0	ITGA2B	2	affinity chromatography technology	Liu B (2012)	1
CD36	2	ITGB3	6	affinity chromatography technology	Miao WM (2001)	1
FGG	1	FGA	5	x-ray crystallography	Kostelansky MS (2002)	1
ITGA2B	2	GRB2	2	pull down	Law DA (1996)	1
FBXO6	0	CLNS1A	2	affinity chromatography technology	Liu B (2012)	1
FN1	17	CLNS1A	2	affinity chromatography technology	Humphries JD (2009)	1
ITGB3	6	FN1	17	pull down	Kauf AC (2001)	1
PRKACA	2	ITGA2B	2	enzymatic study	Hillery CA (1991)	1
ITGA2B	2	PLA2G4A	1	pull down	Prevost N (2009)	1
AUP1	0	ITGA2B	2	affinity chromatography technology, pull down, two hybrid	Kato A (2002), Kato A (2002), Kato A (2002)	3
ITGA2B	2	CIB1	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Naik UP (1997), Naik UP (1997), Yamodo IH (2012), Yamodo IH (2012)	4
CD36	2	ITGA2B	2	affinity chromatography technology	Miao WM (2001)	1
ITGA2B	2	ITGB3	6	pull down, pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yin H (2006), Wang R (1997), Wang R (1997), Ulmer TS (2001), Ulmer TS (2001), Afrasiabi A (2008), Rosenberg N (2004), Vallar L (1999), Ward CM (2000)	9
FN1	17	FGA	5	affinity chromatography technology	Moussavi-Harami SF (2013)	1
FGA	5	ITGA2B	2	unspecified method	Wierzbicka I (1997)	1