PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GLRX3	1	ADAMTSL4	6	two hybrid	Rual JF (2005)	1
GLRX3	1	KRTAP10-8	0	two hybrid	Rolland T (2014)	1
LCE2D	0	KRTAP10-8	0	two hybrid	Rolland T (2014)	1
KRTAP10-9	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
KRTAP4-12	2	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
PLSCR1	0	EFEMP2	0	two hybrid	Rual JF (2005)	1
SPRY2	4	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
SPRY1	2	KRTAP10-5	2	two hybrid	Rolland T (2014)	1
SPRY1	2	LCE2D	0	two hybrid	Rolland T (2014)	1
LCE2D	0	LCE2D	0	two hybrid	Rolland T (2014)	1
SPRY2	4	KRTAP4-12	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
GLRX3	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
KRTAP10-5	2	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
PLSCR1	0	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
SPRY2	4	LCE2D	0	two hybrid	Rolland T (2014)	1
PLSCR1	0	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
EFEMP2	0	LCE2D	0	two hybrid	Rolland T (2014)	1
OTX1	4	KRTAP10-8	0	two hybrid	Rolland T (2014)	1
GLRX3	1	KRTAP10-5	2	two hybrid	Rolland T (2014)	1
OTX1	4	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
LCE2D	0	KRTAP10-5	2	two hybrid	Rolland T (2014)	1
SPRY2	4	KRTAP10-5	2	two hybrid	Rolland T (2014)	1
OTX1	4	LCE2D	0	two hybrid	Rolland T (2014)	1
GLRX3	1	KRTAP4-12	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
OTX1	4	KRTAP10-5	2	two hybrid	Rolland T (2014)	1
KRTAP10-9	1	KRTAP10-8	0	two hybrid	Rolland T (2014)	1
KRTAP4-12	2	KRTAP10-5	2	two hybrid	Rolland T (2014)	1
RGS20	2	GLRX3	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Ewing RM (2007), Rolland T (2014), Huttlin EL (2017)	3
ADAMTSL4	6	KRTAP4-12	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
OTX1	4	ADAMTSL4	6	two hybrid	Yu H (2011)	1
SPRY2	4	ADAMTSL4	6	two hybrid	Rual JF (2005)	1
SPRY2	4	KRTAP10-8	0	two hybrid	Rolland T (2014)	1
OTX1	4	RGS20	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
KRTAP4-12	2	LCE2D	0	two hybrid	Rolland T (2014)	1
SPRY1	2	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
ADAMTSL4	6	LCE2D	0	two hybrid	Rolland T (2014)	1
GLRX3	1	LCE2D	0	two hybrid	Rolland T (2014)	1
PLSCR1	0	LCE2D	0	two hybrid	Rolland T (2014)	1
ADAMTSL4	6	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
ADAMTSL4	6	KRTAP10-5	2	two hybrid	Rolland T (2014)	1
OTX1	4	SPRY2	4	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
GLRX3	1	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
GLRX3	1	EFEMP2	0	two hybrid	Rual JF (2005)	1
KRTAP4-12	2	KRTAP10-8	0	two hybrid	Rolland T (2014)	1
RGS20	2	LCE2D	0	two hybrid	Rolland T (2014)	1
LCE2D	0	391257	0	two hybrid	Rolland T (2014)	1
LCE2D	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
PLSCR1	0	ADAMTSL4	6	two hybrid	Rual JF (2005)	1
OTX1	4	SPRY1	2	two hybrid	Rolland T (2014)	1
PLSCR1	0	GLRX3	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ADAMTSL4	6	KRTAP10-8	0	two hybrid	Rolland T (2014)	1
SPRY1	2	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
OTX1	4	KRTAP4-12	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
SPRY2	4	SPRY1	2	affinity chromatography technology, two hybrid	Mason JM (2004), Rolland T (2014)	2
KRTAP10-8	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
LCE2D	0	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
PLSCR1	0	SPRY2	4	two hybrid	Rual JF (2005)	1
KRTAP4-12	2	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
SPRY1	2	KRTAP10-8	0	two hybrid	Rolland T (2014)	1