Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
HCN1 348980 CILOBRADINE CHEMBL2105984 channel blocker GuideToPharmacologyInteractions
HCN1 348980 CHEMBL2052019 CHEMBL2052019 channel blocker GuideToPharmacologyInteractions
HCN1 348980 IVABRADINE CHEMBL471737 channel blocker GuideToPharmacologyInteractions
HCN1 348980 ZATEBRADINE CHEMBL69679 channel blocker GuideToPharmacologyInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
HCN1 rs79983226 C tramadol metabolism/PK not stated The C allele was significantly associated with decreased conversion of tramadol to M1 in post-mortem cases in the discovery cohort, but this was not replicated. Note that the authors did not assess the CYP2D6 genotype/phenotype of subjects. Allele C is associated with decreased metabolism of tramadol as compared to allele G. 30971809 1451101175