PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ID2	0	RCBTB2	1	affinity chromatography technology	Huttlin EL (2017)	1
E2F4	0	RBL1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen CR (2002), Iavarone A (1999), Schmit F (2007), Moberg K (1996), Magae J (1996), Beijersbergen RL (1994), Ginsberg D (1994), Trimarchi JM (1998)	8
SQSTM1	0	ID2	0	affinity chromatography technology	Li X (2017)	1
CDK2	0	HSPA8	4	affinity chromatography technology	Neganova I (2011)	1
ID2	0	PRMT6	2	two hybrid	Weimann M (2013)	1
TUBA1B	0	TUBB4B	6	biochemical	Havugimana PC (2012)	1
TCF3	7	EEF1A2	18	affinity chromatography technology	Teachenor R (2012)	1
SUV39H1	0	KDM1A	2	two hybrid	Weimann M (2013)	1
NEDD9	3	BCAR1	6	affinity chromatography technology	Law SF (1999)	1
ID2	0	MYOD1	0	two hybrid, affinity chromatography technology, two hybrid	Langlands K (1997), Langlands K (1997), Dube DH (2011)	3
CDK2	0	HSPA5	0	affinity chromatography technology	Neganova I (2011)	1
E2F4	0	SIN3A	13	affinity chromatography technology	Tyagi S (2007)	1
HSPA1A	0	HSPA8	4	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
CDK2	0	RBL1	1	enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Leng X (2002), Zhao J (1998), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	8
ID2	0	KIF20B	3	affinity chromatography technology	Huttlin EL (2017)	1
SUV39H1	0	PRMT6	2	two hybrid	Weimann M (2013)	1
TCF3	7	MYF5	2	two hybrid, pull down	Langlands K (1997), Braun T (1990)	2
TCF4	26	KDM1A	2	affinity chromatography technology	Li X (2015)	1
MAPK8	3	BCAR1	6	affinity chromatography technology	Girardin SE (2001)	1
ID2	0	TCF12	14	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Langlands K (1997), Mathas S (2009), Lee SB (2016), Huttlin EL (2017)	4
TCF4	26	ID4	1	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
NR0B2	1	ID2	0	two hybrid, pull down	Kim JY (2004), Kim JY (2004)	2
PRMT5	3	SREBF1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Liu L (2016), Liu L (2016), Liu L (2016), Liu L (2016)	4
KDM1A	2	RB1	2	affinity chromatography technology, affinity chromatography technology	Chau CM (2008), Chau CM (2008)	2
ID2	0	PHF3	8	affinity chromatography technology	Huttlin EL (2017)	1
ID2	0	ID4	1	affinity chromatography technology	Huttlin EL (2017)	1
TCF3	7	STK38	0	affinity chromatography technology	Teachenor R (2012)	1
TCF4	26	TCF3	7	two hybrid, affinity chromatography technology	Ravasi T (2010), Huttlin EL (2017)	2
ID2	0	RBL1	1	affinity chromatography technology	Lasorella A (2000)	1
ID2	0	WBP11	0	affinity chromatography technology	Huttlin EL (2017)	1
YY1	7	RB1	2	affinity chromatography technology	Hu HM (2007)	1
ID2	0	USP1	4	affinity chromatography technology, affinity chromatography technology	Williams SA (2011), Williams SA (2011)	2
ID2	0	ASB4	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Townley-Tilson WH (2014), Townley-Tilson WH (2014), Townley-Tilson WH (2014)	3
MYOD1	0	SUV39H1	0	pull down, affinity chromatography technology	Mal AK (2006), Mal AK (2006)	2
MAPK1	1	GATA4	4	enzymatic study	Liang Q (2001)	1
ID2	0	DYRK1A	36	affinity chromatography technology, enzymatic study	Lee SB (2016), Lee SB (2016)	2
ID2	0	PRMT5	3	affinity chromatography technology	Lee SB (2016)	1
VHL	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Chen K (2016), Chen K (2016)	2
MAPK1	1	ID2	0	two hybrid	Wang J (2008)	1
MYOD1	0	TCF3	7	pull down, two hybrid, pull down, two hybrid	Maleki SJ (1997), Langlands K (1997), Dear TN (1997), Dear TN (1997)	4
ELOC	0	SQSTM1	0	affinity chromatography technology	Chen K (2016)	1
CDK2	0	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Shintani S (2000), Nair JS (2009), Takaki T (2004), Shen WH (2004), He W (2003), Peiretti A (2003), Harbour JW (1999), Horton LE (1997), Higashi H (1996), Delston RB (2011), Kim KS (2002), Chen W (2004), Liberal V (2012), Boyer Arnold N (2005), Dynlacht BD (1997), Knudsen ES (1996), Jiang W (1998), De Luca A (1997), Chen Z (2002), Hara E (1997), Connell-Crowley L (1997), Matsuura I (2004), Chen J (1996), Gaiddon C (2003), Seo DW (2006), Zarkowska T (1997), Grimmler M (2007), Nakanishi M (1999), Pevarello P (2005), Iyer NG (2007), Chan HM (2001), Pan W (2001)	32
MAPK1	1	DYRK1B	1	enzymatic study	Lee K (2000)	1
ID2	0	MACF1	12	affinity chromatography technology	Huttlin EL (2017)	1
RBL2	5	ID2	0	affinity chromatography technology, affinity chromatography technology	Rodriguez JL (2006), Lasorella A (2000)	2
TCF3	7	ID4	1	affinity chromatography technology	Teachenor R (2012)	1
KDM1A	2	PRMT5	3	genetic interference	Wong AS (2016)	1
SUV39H1	0	RBL2	5	affinity chromatography technology	Nicolas E (2003)	1
ID2	0	AFDN	10	affinity chromatography technology	Huttlin EL (2017)	1
TCF3	7	RB1	2	affinity chromatography technology, affinity chromatography technology	Vitelli L (2000), Vitelli L (2000)	2
KLHL20	2	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
ID2	0	NKX2-5	0	affinity chromatography technology	Ding B (2006)	1
TCF4	26	TCF12	14	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
RHOU	0	ID2	0	pull down	Dart AE (2015)	1
HSPA5	0	HSPA1L	2	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
TCF4	26	MSC	0	two hybrid	Massari ME (1998)	1
ID4	1	OLIG2	2	affinity chromatography technology, affinity chromatography technology	Samanta J (2004), Samanta J (2004)	2
ID2	0	YY1	7	affinity chromatography technology	Huttlin EL (2017)	1
ID2	0	ELOC	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Lee SB (2016), Lee SB (2016), Lee SB (2016), Lee SB (2016)	4
RB1	2	MAPK8	3	affinity chromatography technology	Li H (2001)	1
ID2	0	UBE2E1	1	affinity chromatography technology	Huttlin EL (2017)	1
ID2	0	SUV39H1	0	two hybrid	Weimann M (2013)	1
ID2	0	OLIG1	0	affinity chromatography technology, affinity chromatography technology	Samanta J (2004), Samanta J (2004)	2
VHL	0	ELOC	0	affinity chromatography technology, pull down, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ohh M (1999), Tsuchiya H (1996), Min JH (2002), Li Z (2002), Hacker KE (2008), Kim BY (2008), Baek JH (2007), Baek JH (2007), Kuznetsova AV (2003), Cockman ME (2000), Lisztwan J (1999), Stickle NH (2004), Lai Y (2011), Liu YV (2007), Norman JA (2006), Kinoshita K (2007), Cai Q (2010), Lai Y (2012), Miller F (2005), Mahrour N (2008), Mahrour N (2008), Russell RC (2011), He X (2011), McClellan AJ (2005), Bex C (2007), Pause A (1997), Pause A (1997), Stebbins CE (1999), Iliopoulos O (1998), Feldman DE (2003), Kibel A (1995), Kibel A (1995), Pause A (1999), Pause A (1999), Duan DR (1995), Kamura T (2004), Russell RC (2008), Russell RC (2008), Essers PB (2014), Gerez J (2015), Nguyen HC (2015), Lee SB (2016), Uchida T (2016), Zhang C (2016), Huttlin EL (2017), Sun W (2017), Sun W (2017)	48
ID2	0	TUBA1B	0	affinity chromatography technology	Lee SB (2016)	1
CDK2	0	ID2	0	enzymatic study, enzymatic study	Deed RW (1997), Hara E (1997)	2
OLIG2	2	TCF3	7	affinity chromatography technology	Samanta J (2004)	1
KDM1A	2	SIN3A	13	affinity chromatography technology	You A (2001)	1
BCAR1	6	HSPA5	0	two hybrid	Stelzl U (2005)	1
ID2	0	HSPA1L	2	affinity chromatography technology	Lee SB (2016)	1
ID2	0	HSPA8	4	affinity chromatography technology	Lee SB (2016)	1
ID2	0	ELP4	2	affinity chromatography technology	Lee SB (2016)	1
RB1	2	SUV39H1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Nielsen SJ (2001), Nielsen SJ (2001), Vandel L (2001), Vandel L (2001), Vandel L (2001)	5
VHL	0	HSPA1A	0	biochemical	Feldman DE (2003)	1
ID2	0	STK38	0	affinity chromatography technology	Lee SB (2016)	1
ID2	0	UNC119	4	two hybrid	Stelzl U (2005)	1
ID2	0	TUBB4B	6	affinity chromatography technology	Lee SB (2016)	1
NEDD9	3	TCF3	7	two hybrid	Law SF (1999)	1
MAPK3	4	ID2	0	two hybrid	Wang J (2008)	1
MAPK3	4	SREBF1	5	enzymatic study	Kotzka J (2000)	1
ID2	0	TSTA3	3	two hybrid	Wang J (2011)	1
DYRK1B	1	RBL1	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013)	3
MAPK8	3	HSPA8	4	two hybrid	Vinayagam A (2011)	1
ID2	0	NEDD9	3	affinity chromatography technology, two hybrid	Law SF (1999), Law SF (1999)	2
E2F4	0	ID2	0	affinity chromatography technology	Rodriguez JL (2006)	1
ID2	0	KDM1A	2	two hybrid	Weimann M (2013)	1
ID2	0	RNF113A	0	affinity chromatography technology	Lee SB (2016)	1
TUBB4B	6	TUBB	3	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
ID2	0	OLIG2	2	affinity chromatography technology	Samanta J (2004)	1
TCF4	26	MYOD1	0	two hybrid	Goldfarb AN (1996)	1
GATA4	4	NKX2-5	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down	Garg V (2003), Durocher D (1997), Durocher D (1997), Zhu W (2000), Zhu W (2000), Kim TG (2004), Kim TG (2004)	7
VHL	0	TUBB4B	6	affinity chromatography technology	Lai Y (2011)	1
TUBA1B	0	TUBB	3	biochemical	Havugimana PC (2012)	1
ID2	0	EEF1A2	18	affinity chromatography technology	Lee SB (2016)	1
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
TUBB	3	HSPA1A	0	biochemical	Kristensen AR (2012)	1
ID2	0	MYF5	2	two hybrid	Langlands K (1997)	1
RBL2	5	RBL1	1	affinity chromatography technology	Litovchick L (2007)	1
TCF3	7	PRMT5	3	affinity chromatography technology	Teachenor R (2012)	1
TCF12	14	TCF3	7	affinity chromatography technology	Yoon SJ (2011)	1
DYRK1B	1	RB1	2	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013)	3
SIN3A	13	ID2	0	affinity chromatography technology	Rodriguez JL (2006)	1
YY1	7	HSPA5	0	imaging technique	Cai Y (2007)	1
DYRK1A	36	RBL1	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013)	3
KDM1A	2	UNC119	4	two hybrid	Stelzl U (2005)	1
VHL	0	HSPA8	4	affinity chromatography technology, pull down	Lai Y (2011), Lai Y (2012)	2
ID2	0	C1orf131	2	affinity chromatography technology	Huttlin EL (2017)	1
ID2	0	TCF3	7	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Langlands K (1997), Teachenor R (2012), Mathas S (2009), Langlands K (1997), Lee SB (2016), Huttlin EL (2017)	6
TNS2	3	SUV39H1	0	two hybrid	Grossmann A (2015)	1
YY1	7	SREBF1	5	pull down	Bennett MK (1999)	1
VHL	0	HSPA5	0	pull down	Lai Y (2012)	1
ID2	0	RB1	2	affinity chromatography technology	Lasorella A (2000)	1
ID2	0	MAPK8	3	two hybrid	Wang J (2011)	1
MYOD1	0	PRMT5	3	affinity chromatography technology, pull down	Philipot O (2010), Dacwag CS (2009)	2
RB1	2	E2F4	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fajas L (2000), Iavarone A (1999), Moberg K (1996), Ezhevsky SA (1997), Ginsberg D (1994), Trimarchi JM (1998)	6
KLHL20	2	LRIF1	3	two hybrid	Stelzl U (2005)	1
HSPA1L	2	HSPA1A	0	biochemical	Havugimana PC (2012)	1
TCF3	7	KDM1A	2	affinity chromatography technology	Teachenor R (2012)	1
DYRK1B	1	RBL2	5	affinity chromatography technology	Varjosalo M (2013)	1
ID2	0	HDGFL2	3	affinity chromatography technology	Huttlin EL (2017)	1
OLIG1	0	TCF3	7	affinity chromatography technology	Samanta J (2004)	1
YY1	7	TCF3	7	affinity chromatography technology	Cai Y (2007)	1
ID2	0	GATA4	4	affinity chromatography technology, pull down, pull down	Ding B (2006), Ding B (2006), Ding B (2006)	3
HSPA5	0	HSPA1A	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Hein MY (2015)	3
VHL	0	CDK2	0	affinity chromatography technology	Ewing RM (2007)	1
HSPA5	0	SQSTM1	0	unspecified method, pull down	Cha-Molstad H (2015), Cha-Molstad H (2015)	2
ID2	0	RBM48	1	two hybrid	Stelzl U (2005)	1
DYRK1B	1	ID2	0	enzymatic study, affinity chromatography technology	Lee SB (2016), Lee SB (2016)	2
PRMT5	3	SIN3A	13	affinity chromatography technology, pull down, pull down	Pal S (2003), Pal S (2003), Pal S (2003)	3
SQSTM1	0	MAPK1	1	affinity chromatography technology	Linares JF (2011)	1
ID2	0	SLTM	2	affinity chromatography technology	Huttlin EL (2017)	1
ID2	0	TUBB	3	affinity chromatography technology	Lee SB (2016)	1
ID2	0	CLASP2	4	affinity chromatography technology	Huttlin EL (2017)	1
ID2	0	RBM27	5	affinity chromatography technology	Huttlin EL (2017)	1
HSPA9	2	HSPA8	4	biochemical	Wan C (2015)	1
ID2	0	BCAR1	6	affinity chromatography technology	Law SF (1999)	1
ID2	0	HSPA9	2	affinity chromatography technology	Lee SB (2016)	1
SIN3A	13	NR0B2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Farhana L (2007), Kemper JK (2004), Kemper JK (2004), Miao J (2011)	4
ID2	0	KLHL20	2	affinity chromatography technology	Huttlin EL (2017)	1
SUV39H1	0	RBL1	1	affinity chromatography technology	Nicolas E (2003)	1
HSPA8	4	TUBB	3	biochemical	Wan C (2015)	1
SREBF1	5	ID2	0	pull down	Moldes M (1999)	1
KLHL20	2	HDGFL2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ID2	0	CFDP1	1	affinity chromatography technology	Huttlin EL (2017)	1
ID2	0	SUV39H2	3	two hybrid	Weimann M (2013)	1
RIN3	2	SUV39H1	0	two hybrid	Grossmann A (2015)	1
HSPA5	0	ID2	0	two hybrid, affinity chromatography technology	Wang J (2011), Lee SB (2016)	2
ID2	0	DIDO1	9	affinity chromatography technology	Huttlin EL (2017)	1
SUV39H2	3	LRIF1	3	two hybrid	Vinayagam A (2011)	1
TCF4	26	ID2	0	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Langlands K (1997), Goldfarb AN (1996), Massari ME (1998), Langlands K (1997), Li X (2015), Huttlin EL (2017)	6
E2F4	0	RBL2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Iavarone A (1999), Litovchick L (2007), Schmit F (2007), Kong LJ (2006), Farkas T (2002), Osterloh L (2007), Yakovlev VA (2013), Martin N (2012), Martin N (2012)	9
HSPA5	0	HSPA8	4	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015)	3
VHL	0	STK38	0	affinity chromatography technology	Lai Y (2011)	1
PRMT6	2	PRMT5	3	genetic interference	Wong AS (2016)	1
ID4	1	OLIG1	0	affinity chromatography technology, affinity chromatography technology	Samanta J (2004), Samanta J (2004)	2
ID2	0	RABL6	3	affinity chromatography technology	Huttlin EL (2017)	1
CDK2	0	RBL2	5	enzymatic study, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Lacy S (1997), Zhao J (1998), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Howard CM (2000), Huttlin EL (2017)	9
RIN3	2	ID2	0	two hybrid	Grossmann A (2015)	1
ID2	0	HSPA1A	0	affinity chromatography technology	Lee SB (2016)	1
CDK2	0	HSPA9	2	affinity chromatography technology	Neganova I (2011)	1
MAPK1	1	SREBF1	5	enzymatic study	Kotzka J (2000)	1
KDM1A	2	HSPA1A	0	affinity chromatography technology	Shi YJ (2005)	1
KLHL20	2	SUV39H1	0	two hybrid	Weimann M (2013)	1
ID2	0	ID2	0	two hybrid	Wang J (2011)	1
DYRK1A	36	RB1	2	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013)	3
ID2	0	ZGPAT	3	affinity chromatography technology	Huttlin EL (2017)	1
TNS2	3	ID2	0	two hybrid	Grossmann A (2015)	1
MSC	0	ID2	0	two hybrid	Wong J (2001)	1
MAPK3	4	PHF3	8	affinity chromatography technology	Varjosalo M (2013)	1
CDK2	0	TUBB4B	6	affinity chromatography technology	Neganova I (2011)	1
DYRK1A	36	RBL2	5	affinity chromatography technology	Varjosalo M (2013)	1
CDK2	0	E2F4	0	affinity chromatography technology	So J (2015)	1
ID2	0	VHL	0	pull down, affinity chromatography technology, affinity chromatography technology	Lee SB (2016), Lee SB (2016), Lee SB (2016)	3
MYOD1	0	RB1	2	pull down, pull down, affinity chromatography technology	Mal A (2001), Gu W (1993), Gu W (1993)	3
ID2	0	LRIF1	3	two hybrid	Stelzl U (2005)	1