PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	TP73	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Stindt MH (2015), Puca R (2011), De Laurenzi V (1998), Di Como CJ (1999)	4
AKT1	1	HSPA9	2	affinity chromatography technology, affinity chromatography technology	Zhu QS (2011), Zhu QS (2011)	2
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
HSPA9	2	TP53	0	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wadhwa R (2002), Wadhwa R (2002), Sun Y (2007), Li Y (2012), Fogeron ML (2013), Horikawa I (2014)	6
HSPA9	2	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang H (2011), Yang H (2011), Zanon A (2013)	3
HSPA9	2	80273	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
DNAJA3	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen CY (2013), Foerster S (2013), Tong J (2014)	3
EGFR	5	G3BP1	4	affinity chromatography technology	Yao Z (2017)	1
FGF1	0	HSPA9	2	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Mizukoshi E (1999), Mizukoshi E (1999), Mizukoshi E (1999), Mizukoshi E (1999)	4
CDKN2A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Zhang Y (2003), Zhang Y (2003), Rizos H (2003), Zhang Y (1998), Zhang Y (1998), Li L (2010), Li L (2010), Kamijo T (1998), Stott FJ (1998), Ivanov AA (2017)	10
UBXN2A	1	HSPA9	2	two hybrid, affinity chromatography technology	Sane S (2016), Sane S (2016)	2
MVD	2	HSPA9	2	two hybrid, affinity chromatography technology	Wadhwa R (2003), Wadhwa R (2003)	2
HSPA9	2	DNAJA3	2	enzymatic study, pull down, biochemical	Goswami AV (2012), Goswami AV (2012), Wan C (2015)	3
CDKN2A	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PRKN	1	DNAJA1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2003), Zanon A (2013)	3
DENND2D	2	HSPA9	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SPART	0	HSPA9	2	affinity chromatography technology, affinity chromatography technology	Milewska M (2009), Milewska M (2009)	2
MINOS1	1	HSPA9	2	affinity chromatography technology, affinity chromatography technology	Alkhaja AK (2011), Alkhaja AK (2011)	2
TP53	0	G3BP1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kim MM (2007), Kim MM (2007), Kim MM (2007), Kim MM (2007)	4
HSPA9	2	G3BP1	4	biochemical, affinity chromatography technology	Wan C (2015), Jain S (2016)	2
EGFR	5	CUL4B	8	affinity chromatography technology	Tong J (2014)	1
EGFR	5	MINOS1	1	affinity chromatography technology	Tong J (2014)	1
CUL4B	8	HSPA9	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Hein MY (2015)	2
DENND2D	2	80273	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	DNAJA1	2	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
PRKN	1	TP53	0	pull down, enzymatic study	Jung YY (2017), Jung YY (2017)	2
G3BP1	4	DNAJA1	2	affinity chromatography technology	Jain S (2016)	1
PRKN	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
CUL4B	8	DNAJA1	2	affinity chromatography technology	Bennett EJ (2010)	1
TP53	0	DNAJA1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014), Parrales A (2016), Parrales A (2016)	4
80273	0	TIMM44	1	biochemical	Wan C (2015)	1
HSPA9	2	DNLZ	0	pull down, affinity chromatography technology	Vu MT (2011), Huttlin EL (2017)	2
EGFR	5	HSPA9	2	affinity chromatography technology, affinity chromatography technology	Li J (2013), Yao Z (2017)	2
DNAJC19	2	HSPA9	2	enzymatic study, enzymatic study	Sinha D (2010), Goswami AV (2012)	2
TP73	2	HSPA9	2	biochemical, affinity chromatography technology, affinity chromatography technology	Katayama H (2012), Katayama H (2012), Katayama H (2012)	3
DNAJA1	2	HSPA9	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CUL4B	8	TP53	0	affinity chromatography technology	Thirunavukarasou A (2014)	1
TP53	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HSPA9	2	TIMM44	1	biochemical, pull down	Wan C (2015), Liu Q (2003)	2
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
CDKN2A	1	HSPA9	2	pull down, affinity chromatography technology, affinity chromatography technology	Souza-Rodrigues E (2007), Pimkina J (2009), Pimkina J (2009)	3