PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CUL5	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ehrlich ES (2009), Ehrlich ES (2009), Bennett EJ (2010)	3
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
SHC1	0	HSP90AA1	7	affinity chromatography technology	Brehme M (2009)	1
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
TP53	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Wang C (2003), Akakura S (2001), Peng Y (2001), Nagata Y (1999), Wang J (2011), Burch L (2004), Taipale M (2012), Fogeron ML (2013), Walerych D (2004)	9
SMURF1	4	HSPA1B	1	affinity chromatography technology	Xie Y (2013)	1
FMNL1	3	HSPA1B	1	affinity chromatography technology	Han Y (2013)	1
CUL3	17	BAG4	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	HSPA1B	1	affinity chromatography technology	Bennett EJ (2010)	1
GRB2	2	AP2M1	5	affinity chromatography technology	Blagoev B (2003)	1
CTNNB1	30	HDAC6	0	affinity chromatography technology	Li Y (2008)	1
CUL3	17	YWHAZ	1	affinity chromatography technology	Bennett EJ (2010)	1
GRB2	2	HSP90AA1	7	affinity chromatography technology	Brehme M (2009)	1
PPP5C	2	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Zeke T (2005), Silverstein AM (1997), Schuelke JP (2010), Gano JJ (2010), Cliff MJ (2006), Skarra DV (2011), Skarra DV (2011), Horibe T (2011), Taipale M (2014), Taipale M (2014), Hein MY (2015), Woo SH (2009), Woo SH (2009), Woodford MR (2016), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	17
ARRB2	5	CUL5	1	affinity chromatography technology	Xiao K (2007)	1
ITGA4	4	EPS15	1	affinity chromatography technology	Byron A (2012)	1
PINK1	2	PGAM5	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Imai Y (2010), Imai Y (2010), Imai Y (2010), Imai Y (2010)	4
SHC1	0	AP2M1	5	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
DCUN1D1	0	YWHAB	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	BAG4	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
TCERG1	3	HSPA1B	1	affinity chromatography technology	Lin KT (2004)	1
DYRK2	1	HSPA1B	1	affinity chromatography technology	Maddika S (2009)	1
CUL2	3	HSPA1B	1	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	AP2M1	5	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Foerster S (2013), Li J (2013), Tong J (2014), Li J (2013)	5
CTNNB1	30	YWHAZ	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen CH (2012), Chen CH (2012), Tian Q (2004), Tian Q (2004), Tian Q (2004), Fang D (2007)	6
CYLD	2	ELAVL1	0	affinity chromatography technology	Elliott PR (2016)	1
ADRB2	0	HSPA1B	1	affinity chromatography technology	Roy SJ (2013)	1
CUL1	7	EZH2	4	affinity chromatography technology	Sahasrabuddhe AA (2014)	1
STUB1	4	HSPBP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Arndt V (2005), Alberti S (2004), Alberti S (2004)	3
CUL2	3	YWHAZ	1	affinity chromatography technology	Bennett EJ (2010)	1
YWHAB	1	CEP170	4	affinity chromatography technology	Couzens AL (2013)	1
EPS15	1	GRB2	2	far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Schumacher C (1995), Parachoniak CA (2009), Parachoniak CA (2009), Parachoniak CA (2009)	4
CUL5	1	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017), Zhu Z (2017)	3
HSPA1B	1	HSPBP1	0	two hybrid	Lim J (2006)	1
EGFR	5	STIP1	1	protein complementation assay	Deribe YL (2009)	1
CBL	7	PIK3R2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Lin H (2001), Hartley D (1995), Feshchenko EA (2004), Alcazar I (2009), Brehme M (2009), Brehme M (2009), Grossmann A (2015)	7
CUL4A	2	TP53	0	affinity chromatography technology	Banks D (2006)	1
FBXO6	0	COPS5	0	affinity chromatography technology	Liu B (2012)	1
CUL4A	2	BANF1	0	affinity chromatography technology	Montes de Oca R (2009)	1
VCAM1	2	GRB2	2	affinity chromatography technology	Humphries JD (2009)	1
VCAM1	2	INPPL1	6	affinity chromatography technology	Humphries JD (2009)	1
CUL5	1	COPS5	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
CYLD	2	HDAC6	0	affinity chromatography technology, pull down, affinity chromatography technology	Wickstroem SA (2010), Wickstroem SA (2010), Sun L (2010)	3
NINL	1	ARRB2	5	bioid	Gupta GD (2015)	1
TRIM25	5	HSP90AA1	7	affinity chromatography technology	Choudhury NR (2017)	1
DCUN1D1	0	CAND1	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kim AY (2008), Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Bommelje CC (2013), Kim AY (2008), Huang G (2014), Huang G (2014), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016)	11
CFTR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye S (2010), Ye S (2010), Bomberger JM (2012), Arora K (2016)	4
ITGA4	4	INPPL1	6	affinity chromatography technology	Byron A (2012)	1
FBXO6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2007), Nelson RF (2007), Glenn KA (2008), Yoshida Y (2011), Liu B (2012), Liu B (2012), Huttlin EL (2015), Huttlin EL (2017), Reitsma JM (2017), Reitsma JM (2017)	10
FNIP2	2	STIP1	1	affinity chromatography technology	Woodford MR (2016)	1
COPS6	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Kristensen AR (2012), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
CNTRL	5	CEP170	4	bioid	Gupta GD (2015)	1
CUL4B	8	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
PIK3R2	3	SHC1	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
EGFR	5	HSPA1B	1	imaging technique	Chen TC (2014)	1
FN1	17	HSPA1B	1	affinity chromatography technology	Humphries JD (2009)	1
CUL3	17	PIK3R2	3	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	PGAM5	4	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	DCUN1D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
CFTR	5	CAND1	2	affinity chromatography technology	Wang X (2006)	1
EGFR	5	YWHAB	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
PGAM5	4	CUL3	17	affinity chromatography technology, affinity chromatography technology	Lo SC (2006), Bennett EJ (2010)	2
DCUN1D1	0	COPS6	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	CUL3	17	affinity chromatography technology	Bennett EJ (2010)	1
FLCN	1	PPP5C	2	affinity chromatography technology	Woodford MR (2016)	1
ARRB1	2	YWHAB	1	affinity chromatography technology	Xiao K (2007)	1
ARRB1	2	HSP90AA1	7	affinity chromatography technology	Xiao K (2007)	1
PGAM5	4	HSPA1B	1	two hybrid	Stelzl U (2005)	1
HSP90AA1	7	CFTR	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fuller W (2000), Goldstein RF (2007), Goldstein RF (2007), Sun F (2008), Wang X (2006)	5
SHC1	0	HSPA1B	1	affinity chromatography technology	Brehme M (2009)	1
TP53	0	CYLD	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Fernandez-Majada V (2016), Fernandez-Majada V (2016), Fernandez-Majada V (2016), Fernandez-Majada V (2016)	4
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
TRIM25	5	CTNNB1	30	affinity chromatography technology	Choudhury NR (2017)	1
COPS5	0	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
AP2M1	5	CRY1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CBL	7	HSPA1B	1	affinity chromatography technology	Brehme M (2009)	1
GRB2	2	DAB2	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Tseng CP (1999), Mulkearns EE (2012)	3
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
UBASH3B	4	HSPA1B	1	affinity chromatography technology	Brehme M (2009)	1
CUL4A	2	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
ADRB2	0	HDAC6	0	protein complementation assay	Kittanakom S (2014)	1
EGFR	5	PIK3R2	3	affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, protein complementation assay	Tong J (2009), Jones RB (2006), Foerster S (2013), Kotlyar M (2015), Gout I (1992), Petschnigg J (2014)	6
COPS5	0	CAND1	2	biochemical, affinity chromatography technology	Bornstein G (2006), Bennett EJ (2010)	2
CUL4B	8	EZH2	4	affinity chromatography technology	Yang Y (2015)	1
CCNI2	0	HSPA1B	1	affinity chromatography technology	Huttlin EL (2015)	1
CUL3	17	YWHAB	1	affinity chromatography technology	Bennett EJ (2010)	1
CEP170	4	CBL	7	bioid	Gupta GD (2015)	1
PIK3R2	3	HSPA1B	1	affinity chromatography technology	Brehme M (2009)	1
PPP5C	2	YWHAB	1	affinity chromatography technology	Yadav L (2017)	1
HDAC6	0	STUB1	4	affinity chromatography technology	Cook C (2012)	1
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
RNF2	1	CUL5	1	affinity chromatography technology	Cao Q (2014)	1
COPS5	0	BAG4	2	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	CUL1	7	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Wu K (2011), Bennett EJ (2010), Huang G (2011), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Huang G (2014), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	16
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
VCAM1	2	PIK3R2	3	affinity chromatography technology	Humphries JD (2009)	1
EZH2	4	NINL	1	two hybrid	Stelzl U (2005)	1
SMURF1	4	NEDD8	0	affinity chromatography technology, pull down	He S (2017), He S (2017)	2
CAND1	2	HSPA1B	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	HSPA1B	1	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	GRB2	2	affinity chromatography technology	Bennett EJ (2010)	1
DERL1	2	EGFR	5	affinity chromatography technology, affinity chromatography technology	Dong QZ (2013), Dong QZ (2013)	2
CFTR	5	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun F (2006), Sun F (2006), Younger JM (2006), Wang B (2008), Pankow S (2015)	5
CUL4A	2	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Angers S (2006), Hu J (2004), Chua YS (2011), Tron AE (2012), Zheng J (2002), He YJ (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Gastaldello S (2012), Liu J (2002), Liu J (2002), Olma MH (2009), Olma MH (2009), Yang Y (2016), Yang Y (2016)	18
TRIM25	5	CUL4A	2	affinity chromatography technology	Choudhury NR (2017)	1
CAND1	2	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
CUL4A	2	BAG4	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Schenkova K (2012)	3
COPS6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Reitsma JM (2017)	7
CUL3	17	STAU1	1	affinity chromatography technology	Bennett EJ (2010)	1
PINK1	2	TGM2	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Min B (2015), Min B (2015), Min B (2015), Min B (2015)	4
EGFR	5	YWHAZ	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2009), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
EGFR	5	FBXO6	0	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Liu B (2012)	2
COPS5	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Rao F (2014), Pick E (2012), Groisman R (2003), Groisman R (2003), Huttlin EL (2015), Cavadini S (2016), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	19
FNIP1	2	FNIP2	2	affinity chromatography technology	Woodford MR (2016)	1
TRIM25	5	CBL	7	affinity chromatography technology	Choudhury NR (2017)	1
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
UBL4A	0	HSPA1B	1	affinity chromatography technology	Xu Y (2012)	1
YWHAZ	1	COPS5	0	two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Bennett EJ (2010)	2
ITGA4	4	GRB2	2	affinity chromatography technology	Byron A (2012)	1
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
NEDD8	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
FNIP2	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Woodford MR (2016), Woodford MR (2016)	2
HDAC6	0	HSPA1B	1	affinity chromatography technology	Watson GW (2016)	1
FBXO6	0	NEDD8	0	affinity chromatography technology	Liu B (2012)	1
TP53	0	STUB1	4	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Stankiewicz M (2010), Tripathi V (2007), Tripathi V (2007), Esser C (2005), Lim JH (2011), Wang J (2011), Burch L (2004), Landre V (2013), Horikawa I (2014), Horikawa I (2014), Horikawa I (2014), Fraser JA (2015), Narayan V (2015), Yue X (2016), Parrales A (2016), Parrales A (2016)	17
FBXO6	0	COPS6	0	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015)	2
FNIP2	2	FLCN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dunlop EA (2014), Woodford MR (2016), Woodford MR (2016)	3
FN1	17	PA2G4	1	affinity chromatography technology	Humphries JD (2009)	1
YWHAB	1	HSPA1B	1	affinity chromatography technology	Jin J (2004)	1
NINL	1	TP53	0	bioid	Gupta GD (2015)	1
EPS15	1	AP2M1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	5
VCAM1	2	ELAVL1	0	affinity chromatography technology	Humphries JD (2009)	1
EZH2	4	HSPA1B	1	affinity chromatography technology	Cao Q (2014)	1
ELAVL1	0	HSPA1B	1	affinity chromatography technology	Abdelmohsen K (2009)	1
HSP90AA1	7	HSPA1B	1	affinity chromatography technology, affinity chromatography technology	Skarra DV (2011), Woodford MR (2016)	2
CTNNB1	30	SMURF1	4	affinity chromatography technology, pull down	Boonanantanasarn K (2015), Boonanantanasarn K (2015)	2
ELAVL1	0	BAG4	2	affinity chromatography technology	Abdelmohsen K (2009)	1
NEK8	3	STIP1	1	bioid	Gupta GD (2015)	1
FN1	17	HSP90AA1	7	affinity chromatography technology	Humphries JD (2009)	1
GRB2	2	YWHAZ	1	affinity chromatography technology	Bisson N (2011)	1
TXNIP	2	STIP1	1	bioid	Forred BJ (2016)	1
ITGA4	4	AP2M1	5	affinity chromatography technology	Byron A (2012)	1
UBASH3B	4	INPPL1	6	affinity chromatography technology	Brehme M (2009)	1
COPS6	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	6
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
CRK	0	INPPL1	6	affinity chromatography technology	Brehme M (2009)	1
CUL3	17	CUL2	3	biochemical	Wan C (2015)	1
EPS15	1	CRK	0	far western blotting, pull down, affinity chromatography technology, affinity chromatography technology	Schumacher C (1995), Schumacher C (1995), Brehme M (2009), Brehme M (2009)	4
ARRB2	5	STUB1	4	affinity chromatography technology	Zhang Z (2009)	1
YWHAB	1	PIK3R2	3	affinity chromatography technology	Jin J (2004)	1
TRIM25	5	STUB1	4	affinity chromatography technology	Choudhury NR (2017)	1
GRB2	2	FN1	17	two hybrid, affinity chromatography technology	Wang J (2008), Humphries JD (2009)	2
TRIM25	5	FNIP1	2	affinity chromatography technology	Choudhury NR (2017)	1
CFTR	5	TGM2	2	affinity chromatography technology	Pankow S (2015)	1
EGFR	5	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Schulze WX (2006), Sakaguchi K (1998), Tong J (2009), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Burke P (2001), Katayama H (1999), Tong J (2008), Zhang L (1999), Levkowitz G (1999), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Foerster S (2013), Gotoh N (1994), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Li J (2013), Prigent SA (1996), Prigent SA (1996), Grosse R (2000), Yao Z (2017), Wills MK (2014), Wills MK (2014), Kapoor GS (2010)	29
ARRB2	5	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Huttlin EL (2017)	4
EGFR	5	ARRB2	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
ELAVL1	0	STIP1	1	biochemical	Wan C (2015)	1
RNF2	1	PGAM5	4	affinity chromatography technology	Cao Q (2014)	1
COPS6	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	BAG4	2	affinity chromatography technology	Bennett EJ (2010)	1
BAG4	2	HSP90AA1	7	affinity chromatography technology	Lau PP (2003)	1
EGFR	5	HDAC6	0	affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Gao YS (2010), Deribe YL (2009), Deribe YL (2009), Deribe YL (2009), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	7
FN1	17	DAB2	1	affinity chromatography technology	Humphries JD (2009)	1
CUL4B	8	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
TGM2	2	YWHAZ	1	biochemical	Kristensen AR (2012)	1
CUL4B	8	STUB1	4	biochemical	Kristensen AR (2012)	1
CUL3	17	AP2M1	5	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	UBQLN2	0	biochemical	Kristensen AR (2012)	1
TRIM25	5	HSPA1B	1	affinity chromatography technology, affinity chromatography technology	Pauli EK (2014), Choudhury NR (2017)	2
GRB2	2	YWHAB	1	affinity chromatography technology	Bisson N (2011)	1
CRK	0	HSPA1B	1	affinity chromatography technology	Brehme M (2009)	1
RNF2	1	TRIM25	5	affinity chromatography technology	Cao Q (2014)	1
HDAC6	0	CFTR	5	affinity chromatography technology, affinity chromatography technology	Kawaguchi Y (2003), Ouyang H (2012)	2
KLHL34	0	STIP1	1	affinity chromatography technology	Huttlin EL (2017)	1
PPP5C	2	STIP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skarra DV (2011), Skarra DV (2011), Yadav L (2017), Yadav L (2017)	4
SLC27A3	1	STUB1	4	affinity chromatography technology	Huttlin EL (2017)	1
FNIP1	2	STIP1	1	affinity chromatography technology	Woodford MR (2016)	1
NEDD8	0	YWHAZ	1	affinity chromatography technology	Bennett EJ (2010)	1
NINL	1	CEP170	4	bioid	Gupta GD (2015)	1
CEP170	4	SHC1	0	bioid	Gupta GD (2015)	1
EGFR	5	CEP170	4	affinity chromatography technology	Yao Z (2017)	1
CUL5	1	BAG4	2	affinity chromatography technology	Bennett EJ (2010)	1
EZH2	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Li X (2009), Li X (2009), Shi B (2007), Shi B (2007), Shi B (2007)	5
EGFR	5	UBASH3B	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kowanetz K (2004), Raguz J (2007), Raguz J (2007), Tong J (2008), Foerster S (2013), Li J (2013), Tong J (2014), Li J (2013)	8
CRY1	0	HSPA1B	1	affinity chromatography technology	Papp SJ (2015)	1
CUL2	3	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
CEP170	4	HSPA1B	1	bioid	Gupta GD (2015)	1
UBQLN2	0	HSPA1B	1	affinity chromatography technology	Hjerpe R (2016)	1
PINK1	2	HSPA1B	1	affinity chromatography technology	Murata H (2013)	1
EGFR	5	INPPL1	6	affinity chromatography technology, affinity chromatography technology	Pesesse X (2001), Sanada F (2009)	2
ITGA4	4	CBL	7	affinity chromatography technology	Byron A (2012)	1
CUL1	7	YWHAZ	1	affinity chromatography technology	Bennett EJ (2010)	1
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
UBASH3B	4	CRK	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
YWHAZ	1	HSPA1B	1	affinity chromatography technology	Jin J (2004)	1
ELAVL1	0	TXNIP	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CUL5	1	CUL1	7	affinity chromatography technology	Bennett EJ (2010)	1
CTNNB1	30	COPS5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huang X (2009), Jumpertz S (2014), Jumpertz S (2014)	3
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
KLHL34	0	HSPA1B	1	affinity chromatography technology	Huttlin EL (2017)	1
SLC27A3	1	HSPA1B	1	affinity chromatography technology	Huttlin EL (2017)	1
RNF2	1	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
EGFR	5	ARRB1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
AP2M1	5	CRK	0	affinity chromatography technology	Brehme M (2009)	1
CUL1	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
VCAM1	2	YWHAB	1	affinity chromatography technology	Humphries JD (2009)	1
CFTR	5	TP53	0	affinity chromatography technology	Pankow S (2015)	1
HSPA1B	1	STIP1	1	biochemical	Wan C (2015)	1
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
NINL	1	HSPA1B	1	bioid	Gupta GD (2015)	1
VCAM1	2	HSPA1B	1	affinity chromatography technology	Humphries JD (2009)	1
ELAVL1	0	UBQLN2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CRK	0	TP53	0	two hybrid	Grossmann A (2015)	1
FN1	17	ITGA4	4	affinity chromatography technology	Humphries JD (2009)	1
EGFR	5	FN1	17	protein complementation assay	Deribe YL (2009)	1
CUL1	7	BAG4	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	DCUN1D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016)	8
GRB2	2	HSPA1B	1	affinity chromatography technology	Brehme M (2009)	1
NEDD8	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012)	4
HSP90AA1	7	NEK8	3	affinity chromatography technology	Taipale M (2012)	1
STAU1	1	AP2M1	5	affinity chromatography technology	Milev MP (2012)	1
CUL1	7	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chua YS (2011), Chua YS (2011), Tron AE (2012), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Liu J (2002), Huttlin EL (2017)	8
ARRB1	2	CUL3	17	affinity chromatography technology	Skieterska K (2016)	1
BAG4	2	STUB1	4	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
ELAVL1	0	YWHAB	1	affinity chromatography technology	Abdelmohsen K (2009)	1
BAG4	2	HSPA1B	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
TP53	0	TGM2	2	affinity chromatography technology, affinity chromatography technology	Kang JH (2016), Kang JH (2016)	2
TP53	0	UBQLN2	0	genetic interference	Xie L (2013)	1
VCAM1	2	EPS15	1	affinity chromatography technology	Humphries JD (2009)	1
CYLD	2	PGAM5	4	affinity chromatography technology	Elliott PR (2016)	1
CUL4B	8	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Min KW (2003), Bennett EJ (2010), Bennett EJ (2010), Hein MY (2015)	6
CBL	7	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park RK (1999), Gesbert F (1998), Erdreich-Epstein A (1997), Wang Y (1999), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Brizzi MF (1996), Fukazawa T (1996)	9
CUL3	17	CTNNB1	30	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
STAU1	1	YWHAZ	1	affinity chromatography technology	Milev MP (2012)	1
ELAVL1	0	HDAC6	0	affinity chromatography technology, affinity chromatography technology	Scott GK (2008), Scott GK (2008)	2
COPS5	0	PGAM5	4	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	CUL4B	8	affinity chromatography technology	Tong J (2014)	1
CNTRL	5	HSPA1B	1	bioid	Gupta GD (2015)	1
CTNNB1	30	HSPA1B	1	affinity chromatography technology	Tian Q (2004)	1
COPS5	0	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang XC (2008), Zhang XC (2008), Zhang XC (2008), Wang J (2006), Bech-Otschir D (2001), Bech-Otschir D (2001), Oh W (2006), Bhansali M (2014), Bhansali M (2014)	9
VCAM1	2	HSP90AA1	7	affinity chromatography technology	Humphries JD (2009)	1
SMURF1	4	TP53	0	affinity chromatography technology	Nie J (2010)	1
UBL4A	0	HSP90AA1	7	affinity chromatography technology	Xu Y (2012)	1
HSP90AA1	7	KLHL34	0	affinity chromatography technology	Taipale M (2012)	1
ARRB2	5	YWHAB	1	affinity chromatography technology	Xiao K (2007)	1
NPHP4	10	HSPA1B	1	bioid	Gupta GD (2015)	1
DCUN1D1	0	HSPA1B	1	affinity chromatography technology	Bennett EJ (2010)	1
CRY1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2007), Papp SJ (2015), Huttlin EL (2017)	3
FN1	17	YWHAB	1	affinity chromatography technology	Humphries JD (2009)	1
CFTR	5	YWHAZ	1	affinity chromatography technology	Pankow S (2015)	1
TRIM25	5	YWHAZ	1	affinity chromatography technology	Choudhury NR (2017)	1
DAB2	1	AP2M1	5	affinity chromatography technology	Mulkearns EE (2012)	1
DCUN1D1	0	CUL5	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
DCUN1D1	0	COPS5	0	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	HSPA1B	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	CTNNB1	30	affinity chromatography technology	Tripathi R (2007)	1
EGFR	5	CRK	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Schulze WX (2006), Hashimoto Y (1998), Hashimoto Y (1998), Katayama H (1999), Ota S (1998), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	9
CUL4A	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Bennett EJ (2010), Taipale M (2012)	3
ITGA4	4	HSPA1B	1	affinity chromatography technology	Byron A (2012)	1
PINK1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2010), Weihofen A (2008), Weihofen A (2008), Moriwaki Y (2008), Moriwaki Y (2008), Taipale M (2012), Ando M (2017)	7
FGFR3	7	HSPA1B	1	affinity chromatography technology	Laederich MB (2011)	1
DCUN1D1	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
EZH2	4	TRIM25	5	affinity chromatography technology	Cao Q (2014)	1
AP2M1	5	HSPA1B	1	affinity chromatography technology	Brehme M (2009)	1
CFTR	5	CTNNB1	30	affinity chromatography technology	Pankow S (2015)	1
COPS6	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	6
DCUN1D1	0	CUL2	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Monda JK (2013), Heir P (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016), Chen K (2016)	13
TRIM25	5	PPP5C	2	affinity chromatography technology	Choudhury NR (2017)	1
COPS6	0	HSPA1B	1	affinity chromatography technology	Bennett EJ (2010)	1
FBXO6	0	HSPA1B	1	affinity chromatography technology	Liu B (2012)	1
TXNIP	2	HSPA1B	1	bioid	Forred BJ (2016)	1
TRIM25	5	YWHAB	1	affinity chromatography technology	Choudhury NR (2017)	1
CUL5	1	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
GRB2	2	TCERG1	3	two hybrid	Bandyopadhyay S (2010)	1
PPP5C	2	HSPA1B	1	affinity chromatography technology	Skarra DV (2011)	1
DERL1	2	CAND1	2	affinity chromatography technology	You H (2017)	1
CFTR	5	EGFR	5	affinity chromatography technology	Pankow S (2015)	1
FLCN	1	FNIP1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Baba M (2006), Baba M (2006), Baba M (2006), Baba M (2006), Baba M (2006), Baba M (2006), Woodford MR (2016), Woodford MR (2016), Woodford MR (2016)	9
TGM2	2	FN1	17	pull down, affinity chromatography technology	Heath DJ (2002), Humphries JD (2009)	2
VCAM1	2	AP2M1	5	affinity chromatography technology	Humphries JD (2009)	1
CEP170	4	ARRB2	5	bioid	Gupta GD (2015)	1
ITGA4	4	PA2G4	1	affinity chromatography technology	Byron A (2012)	1
CRY1	0	YWHAB	1	affinity chromatography technology	Papp SJ (2015)	1
FNIP1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Baba M (2006), Woodford MR (2016), Woodford MR (2016), Woodford MR (2016), Woodford MR (2016)	5
FBXO6	0	TGM2	2	affinity chromatography technology	Liu B (2012)	1
CFTR	5	DAB2	1	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Collaco A (2010)	2
CRY1	0	YWHAZ	1	affinity chromatography technology	Papp SJ (2015)	1
CAND1	2	STAU1	1	affinity chromatography technology	Bennett EJ (2010)	1
ADRB2	0	CUL2	3	affinity chromatography technology	Xie L (2009)	1
TRIM25	5	CUL5	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	PGAM5	4	affinity chromatography technology	Choudhury NR (2017)	1
FNIP2	2	HSPA1B	1	affinity chromatography technology	Woodford MR (2016)	1
CRK	0	HSPBP1	0	affinity chromatography technology	Brehme M (2009)	1
TRIM25	5	STIP1	1	affinity chromatography technology	Choudhury NR (2017)	1
CUL5	1	HSPA1B	1	affinity chromatography technology	Bennett EJ (2010)	1
UBASH3B	4	CBL	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kowanetz K (2004), Kowanetz K (2004), Raguz J (2007), Hoeller D (2006), Peruzzi G (2007), Brehme M (2009)	6
DCUN1D1	0	CUL3	17	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Monda JK (2013), Wan C (2015), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Huttlin EL (2017)	19
ITGA4	4	PIK3R2	3	affinity chromatography technology	Byron A (2012)	1
ARRB1	2	STUB1	4	affinity chromatography technology	Zhang Z (2009)	1
YWHAZ	1	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology	Waterman MJ (1998), Waterman MJ (1998), Gu YM (2006)	3
CFTR	5	STAU1	1	affinity chromatography technology	Pankow S (2015)	1
ELAVL1	0	UBASH3B	4	affinity chromatography technology	Abdelmohsen K (2009)	1
ARRB1	2	YWHAZ	1	affinity chromatography technology	Xiao K (2007)	1
EPS15	1	HSPA1B	1	affinity chromatography technology	Brehme M (2009)	1
DCUN1D1	0	BAG4	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
HDAC6	0	YWHAZ	1	enzymatic study	Mortenson JB (2015)	1
FBXO6	0	YWHAZ	1	affinity chromatography technology	Liu B (2012)	1
TRIM25	5	GRB2	2	affinity chromatography technology	Choudhury NR (2017)	1
COPS5	0	FNIP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DCUN1D1	0	NEDD8	0	affinity chromatography technology	Bennett EJ (2010)	1
CBL	7	INPPL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vandenbroere I (2003), Prasad NK (2005), De Schutter J (2009), De Schutter J (2009), Brehme M (2009)	5
CUL3	17	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	STAU1	1	affinity chromatography technology	Bennett EJ (2010)	1
TP53	0	TXNIP	2	affinity chromatography technology	Suh HW (2013)	1
CYLD	2	HSP90AA1	7	affinity chromatography technology	Elliott PR (2016)	1
VCAM1	2	STIP1	1	affinity chromatography technology	Humphries JD (2009)	1
CEP170	4	GRB2	2	bioid	Gupta GD (2015)	1
FLCN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Woodford MR (2016), Woodford MR (2016), Woodford MR (2016), Woodford MR (2016)	4
COPS6	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	12
COPS6	0	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009)	5
ELAVL1	0	STAU1	1	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Milev MP (2012)	2
CUL3	17	GRB2	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Menon S (2008), Mao X (2011), Chua YS (2011), Chua YS (2011), Tron AE (2012)	7
VCAM1	2	ITGA4	4	affinity chromatography technology, affinity chromatography technology	Humphries JD (2009), Byron A (2012)	2
SHC1	0	INPPL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wisniewski D (1999), Wisniewski D (1999), Pesesse X (2001), Habib T (1998), Brehme M (2009), Brehme M (2009)	6
INPPL1	6	HSPA1B	1	affinity chromatography technology	Brehme M (2009)	1
SHC1	0	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Ota S (1998), Larsson H (1999)	4
CFTR	5	YWHAB	1	affinity chromatography technology	Pankow S (2015)	1
COPS5	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Fang L (2008), Sharon M (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Choi HH (2011), Kristensen AR (2012), Birol M (2014), Birol M (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	18
CUL4B	8	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
ELAVL1	0	GRB2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
DERL1	2	HSPA1B	1	affinity chromatography technology	You H (2017)	1
STUB1	4	CFTR	5	enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Younger JM (2004), Summers DW (2009), Ren HY (2011), Meacham GC (2001), Schmidt BZ (2009), Alberti S (2004)	6
CUL4A	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Angers S (2006), Bennett EJ (2010), Bennett EJ (2010), Sertic S (2013)	5
CBL	7	YWHAB	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Robertson H (1997), Robertson H (1997), Robertson H (1997), Subramanian RR (2001), Chernock RD (2001), Brehme M (2009), Couzens AL (2013)	7
FGFR3	7	GRB2	2	affinity chromatography technology, biochemical	Kanai M (1997), Wan C (2015)	2
ARRB2	5	HSPA1B	1	affinity chromatography technology	Xiao K (2007)	1
UBASH3B	4	CUL3	17	pull down	Krupina K (2016)	1
RNF2	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Calao M (2012), Wen W (2013), Wen W (2013)	3
LRRC28	1	CUL5	1	affinity chromatography technology	Huttlin EL (2017)	1
ARRB1	2	HSPA1B	1	affinity chromatography technology	Xiao K (2007)	1
CTNNB1	30	CUL1	7	affinity chromatography technology	Read MA (2000)	1
FLCN	1	STUB1	4	affinity chromatography technology, affinity chromatography technology	Woodford MR (2016), Woodford MR (2016)	2
UBL4A	0	PA2G4	1	affinity chromatography technology	Xu Y (2012)	1
UBQLN2	0	EPS15	1	affinity chromatography technology	NDiaye EN (2008)	1
NPHP4	10	STIP1	1	bioid	Gupta GD (2015)	1
FN1	17	ELAVL1	0	affinity chromatography technology	Humphries JD (2009)	1
HSPA1B	1	TGM2	2	two hybrid	Wang J (2011)	1
CUL3	17	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
CTNNB1	30	CBL	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Chitalia V (2013), Chitalia V (2013), Chitalia V (2013), Shivanna S (2015)	4
CUL2	3	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
FN1	17	STIP1	1	affinity chromatography technology	Humphries JD (2009)	1
CUL2	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
CTNNB1	30	ELAVL1	0	pull down	Kim I (2012)	1
GRB2	2	PPP5C	2	affinity chromatography technology	Bisson N (2011)	1
CBL	7	YWHAZ	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Robertson H (1997), Subramanian RR (2001), Wang H (1998)	3
GRB2	2	CYLD	2	affinity chromatography technology	Huttlin EL (2017)	1
CBL	7	TGM2	2	affinity chromatography technology, pull down	Zhang J (2013), Zhang J (2013)	2
CUL4A	2	CUL1	7	biochemical	He YJ (2006)	1
LRRC28	1	HSPA1B	1	affinity chromatography technology	Huttlin EL (2015)	1
CYLD	2	YWHAZ	1	affinity chromatography technology	Elliott PR (2016)	1
TRIM25	5	CAND1	2	affinity chromatography technology	Choudhury NR (2017)	1
CFTR	5	HSPA1B	1	affinity chromatography technology	Pankow S (2015)	1
YWHAB	1	CYLD	2	affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Elliott PR (2016)	2
NPHP4	10	HSP90AA1	7	bioid	Gupta GD (2015)	1
EGFR	5	NPHP4	10	affinity chromatography technology	Yao Z (2017)	1
CAND1	2	BAG4	2	affinity chromatography technology	Bennett EJ (2010)	1
UBASH3B	4	HSP90AA1	7	affinity chromatography technology	Brehme M (2009)	1
TRIM25	5	AP2M1	5	affinity chromatography technology	Choudhury NR (2017)	1
TCERG1	3	FMNL1	3	pull down	Ingham RJ (2005)	1
FN1	17	EPS15	1	affinity chromatography technology	Humphries JD (2009)	1
NEDD8	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
CUL4B	8	TP53	0	affinity chromatography technology	Thirunavukarasou A (2014)	1
DAB2	1	HSPA1B	1	affinity chromatography technology	Mulkearns EE (2012)	1
EGFR	5	STUB1	4	protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Wang T (2014), Wang T (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Chung C (2016), Chung C (2016)	8
FBXO6	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Taipale M (2012)	2
SHC1	0	UBASH3B	4	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
NEK8	3	HSPA1B	1	bioid	Gupta GD (2015)	1
STIP1	1	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Scheufler C (2000), Johnson BD (1998), Mollapour M (2010), Li J (2011), Kundrat L (2010), Tsutsumi S (2012), Sarkar S (2012), Gano JJ (2010), Skarra DV (2011), Horibe T (2011), Brinker A (2002), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Graumann K (2000), Hein MY (2015), Chadli A (2010), Chadli A (2008), Woodford MR (2016), Scholz GM (2001), Sun L (2012), Woodford MR (2016), Huttlin EL (2017)	23
EZH2	4	STUB1	4	affinity chromatography technology	Wang X (2017)	1
GRB2	2	PIK3R2	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
YWHAB	1	TP53	0	affinity chromatography technology	Lee MK (2007)	1
ITGA4	4	YWHAZ	1	affinity chromatography technology	Byron A (2012)	1
FLCN	1	STIP1	1	affinity chromatography technology	Woodford MR (2016)	1
EGFR	5	PPP5C	2	protein complementation assay	Deribe YL (2009)	1
STUB1	4	HSPA1B	1	affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Taipale M (2014), Taipale M (2014), Grelle G (2006), Grelle G (2006)	4
EGFR	5	CTNNB1	30	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hazan RB (1998), Schroeder JA (2002), Takahashi K (1997), Li J (2013)	4
ITGA4	4	YWHAB	1	affinity chromatography technology	Byron A (2012)	1
CFTR	5	CEP170	4	affinity chromatography technology	Wang X (2006)	1
DERL1	2	TRIM25	5	affinity chromatography technology	You H (2017)	1
ADRB2	0	GRB2	2	affinity chromatography technology, pull down	Karoor V (1998), Karoor V (1998)	2
VCAM1	2	YWHAZ	1	affinity chromatography technology	Humphries JD (2009)	1
CUL1	7	HSPA1B	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), He F (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
FGFR3	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Laederich MB (2011), Taipale M (2012)	2
DENND2D	2	HSPA1B	1	affinity chromatography technology	Huttlin EL (2015)	1
ADRB2	0	ARRB2	5	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Kittanakom S (2014), Tian X (2016), Tian X (2016)	3
AP2M1	5	CTNNB1	30	affinity chromatography technology	Li J (2013)	1
TXNIP	2	COPS5	0	affinity chromatography technology	Yamaguchi F (2008)	1
FNIP1	2	HSPA1B	1	affinity chromatography technology	Woodford MR (2016)	1
CYLD	2	STAU1	1	affinity chromatography technology	Elliott PR (2016)	1
CRK	0	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, two hybrid	Gesbert F (1998), Husson H (1997), Ingham RJ (1996), Ingham RJ (1996), Delehanty LL (2003), Garcia-Guzman M (2000), Garcia-Guzman M (2000), Barber DL (1997), Buday L (1996), Sawasdikosol S (1996), Sawasdikosol S (1996), Thien CB (1997), van Leeuwen JE (1999), Ribon V (1996), Lottin-Divoux S (2006), Reedquist KA (1996), Brehme M (2009), Brehme M (2009), Ota S (1998), Peterson ME (2008), Liu BA (2012), Fukazawa T (1996), Umehara H (2002), Grossmann A (2015)	24
FN1	17	TCERG1	3	affinity chromatography technology	Humphries JD (2009)	1
ITGA4	4	TCERG1	3	affinity chromatography technology	Byron A (2012)	1
INPPL1	6	PIK3R2	3	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
TP53	0	HSPA1B	1	affinity chromatography technology, imaging technique	Horikawa I (2014), Chen TC (2014)	2
CUL5	1	CUL2	3	affinity chromatography technology	Bennett EJ (2010)	1
KLHL34	0	STUB1	4	affinity chromatography technology	Huttlin EL (2017)	1
INPPL1	6	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
ARRB2	5	CUL3	17	affinity chromatography technology	Skieterska K (2016)	1
SMURF1	4	UBQLN2	0	enzymatic study	Andrews PS (2010)	1
FN1	17	CAND1	2	affinity chromatography technology	Humphries JD (2009)	1
CUL1	7	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Min KW (2003), Menon S (2008), Chew EH (2007), Min KW (2005), Min KW (2005), Min KW (2005), Hwang JW (2003), Hwang JW (2003), Mao X (2011), Chua YS (2011), Chua YS (2011), Tron AE (2012), Zheng J (2002), Zheng J (2002), Bornstein G (2006), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), He YJ (2006), Emberley ED (2012), Choo YY (2011), Jonason JH (2007), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Liu J (2002), Liu J (2002), Liu J (2002), Liu J (2002), Korzeniewski N (2012), Pierce NW (2013), Kim AY (2008), Zhang S (2016), Tikhmyanova N (2017), Tikhmyanova N (2017), Reitsma JM (2017), Reitsma JM (2017)	41
RNF2	1	SLC27A3	1	affinity chromatography technology	Cao Q (2014)	1
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
FN1	17	AP2M1	5	affinity chromatography technology	Humphries JD (2009)	1
FN1	17	YWHAZ	1	affinity chromatography technology	Humphries JD (2009)	1
TRIM25	5	UBASH3B	4	affinity chromatography technology	Choudhury NR (2017)	1
FN1	17	PGAM5	4	affinity chromatography technology	Humphries JD (2009)	1
COPS5	0	HSPA1B	1	affinity chromatography technology	Bennett EJ (2010)	1
STUB1	4	PA2G4	1	affinity chromatography technology, far western blotting	Ko HR (2014), Hwang I (2016)	2
STAU1	1	HSPA1B	1	affinity chromatography technology	Milev MP (2012)	1
DYRK2	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Maddika S (2009), Taipale M (2012)	2
CUL4A	2	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Angers S (2006), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009)	7
HDAC6	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Kekatpure VD (2009), Rao R (2008), Bali P (2005), Kovacs JJ (2005), New M (2013), Rao R (2012), Kovacs JJ (2005)	7
ARRB1	2	PIK3R2	3	affinity chromatography technology, two hybrid	Xiao K (2007), Wang J (2011)	2
CUL3	17	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Chua YS (2011), Chua YS (2011), Tron AE (2012), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Schumacher FR (2015), Schumacher FR (2015), Lo SC (2006), Lo SC (2006)	12
COPS5	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
CYLD	2	HSPA1B	1	affinity chromatography technology	Elliott PR (2016)	1
NEDD8	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Wimuttisuk W (2007)	4
UBASH3B	4	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), Li J (2013), Li J (2013)	3
TRIM25	5	INPPL1	6	affinity chromatography technology	Choudhury NR (2017)	1
COPS5	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Pick E (2012)	7
EZH2	4	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
BANF1	0	HSPA1B	1	affinity chromatography technology	Montes de Oca R (2009)	1
FLCN	1	HSPA1B	1	affinity chromatography technology, affinity chromatography technology	Woodford MR (2016), Woodford MR (2016)	2
ARRB2	5	AP2M1	5	affinity chromatography technology	Boularan C (2007)	1
ITGA4	4	STIP1	1	affinity chromatography technology	Byron A (2012)	1
ELAVL1	0	EPS15	1	affinity chromatography technology	Abdelmohsen K (2009)	1
PIK3R2	3	CRK	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Brehme M (2009), Brehme M (2009), Grossmann A (2015)	3
PA2G4	1	HSPA1B	1	affinity chromatography technology	Liu Z (2009)	1
EPS15	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	van Delft S (1997), Sigismund S (2005), Bertelsen V (2011), Parachoniak CA (2009), Parachoniak CA (2009), Hoeller D (2006)	6
RNF2	1	HSPA1B	1	affinity chromatography technology	Cao Q (2014)	1
CUL3	17	HSPA1B	1	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	NEK8	3	affinity chromatography technology	Yao Z (2017)	1
NINL	1	CYLD	2	bioid	Gupta GD (2015)	1