Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
TBX21 30009 DEXTROMETHORPHAN CHEMBL52440 NCI 17445473

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
TBX21 rs17250932 CC Tumor necrosis factor alpha efficacy yes When comparing responders vs. non-responders. However, no significant association was seen when comparing the CT vs TT genotype, or the CC + CT vs TT genotype. Additionally, no association was seen for any genotype when considering responders vs. non- and partial-responders. Genotype CC is associated with decreased response to Tumor necrosis factor alpha (TNF-alpha) inhibitors in people with Colitis, Ulcerative as compared to genotype TT. 28139755 1448604179
TBX21 rs2240017 CG corticosteroids efficacy yes There were no GG individuals. Genotype CG is associated with increased response to corticosteroids in children with Asthma as compared to genotype CC. 15604153 981477503