PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PACSIN1	0	RTKN2	2	two hybrid	Bandyopadhyay S (2010)	1
ITCH	1	PACSIN1	0	fluorescent resonance energy transfe, affinity chromatography technology, far western blotting, pull down, unspecified method	Desrochers G (2015), Desrochers G (2015), Desrochers G (2015), Desrochers G (2015), Desrochers G (2017)	5
PACSIN1	0	COBL	4	two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Huttlin EL (2017)	2
PACSIN2	0	WIPF1	0	affinity chromatography technology	Linkermann A (2009)	1
HSPA1A	0	HSPA8	4	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
PACSIN1	0	HSPA8	4	affinity chromatography technology	Linkermann A (2009)	1
PACSIN2	0	HSPA1A	0	affinity chromatography technology	Linkermann A (2009)	1
PACSIN2	0	KHDRBS1	1	affinity chromatography technology	Linkermann A (2009)	1
PACSIN2	0	MPRIP	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PACSIN3	2	WIPF1	0	affinity chromatography technology	Linkermann A (2009)	1
POT1	2	PACSIN2	0	two hybrid	Lee OH (2011)	1
PACSIN2	0	PACSIN1	0	two hybrid, two hybrid, pull down, pull down, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Modregger J (2000), Modregger J (2000), Modregger J (2000), Modregger J (2000), Bandyopadhyay S (2010), Rolland T (2014), Huttlin EL (2017)	8
PACSIN3	2	COBLL1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PACSIN2	0	ASAP1	1	affinity chromatography technology	Linkermann A (2009)	1
PACSIN1	0	GAS7	0	two hybrid	Bandyopadhyay S (2010)	1
PACSIN2	0	CYFIP2	7	affinity chromatography technology	Linkermann A (2009)	1
PACSIN1	0	FTH1	0	two hybrid	Bandyopadhyay S (2010)	1
PACSIN2	0	RAI14	4	affinity chromatography technology	Huttlin EL (2017)	1
PACSIN1	0	CARS	1	affinity chromatography technology	Linkermann A (2009)	1
PACSIN1	0	ANKRD24	5	two hybrid	Bandyopadhyay S (2010)	1
PACSIN3	2	WAS	0	affinity chromatography technology	Linkermann A (2009)	1
PACSIN2	0	COBLL1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNM2	2	DNM1	21	two hybrid	Vinayagam A (2011)	1
PACSIN2	0	PACSIN3	2	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Modregger J (2000), Modregger J (2000), Modregger J (2000), Huttlin EL (2015), Huttlin EL (2017)	5
SYNM	3	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology	Pitre A (2012), Pitre A (2012)	2
PACSIN3	2	DNM2	2	affinity chromatography technology	Linkermann A (2009)	1
PACSIN2	0	DNM2	2	affinity chromatography technology	Linkermann A (2009)	1
PACSIN2	0	MICALL1	1	affinity chromatography technology	Linkermann A (2009)	1
PACSIN1	0	HTT	14	two hybrid, pull down	Modregger J (2002), Modregger J (2002)	2
PACSIN2	0	HSPA8	4	affinity chromatography technology	Linkermann A (2009)	1
PACSIN3	2	MICALL1	1	affinity chromatography technology, affinity chromatography technology	Linkermann A (2009), Huttlin EL (2017)	2
POT1	2	PACSIN1	0	two hybrid	Lee OH (2011)	1
PACSIN3	2	HSPA1A	0	affinity chromatography technology	Linkermann A (2009)	1
RAI14	4	TRIOBP	8	biochemical	Wan C (2015)	1
PACSIN1	0	SPTBN1	6	two hybrid	Bandyopadhyay S (2010)	1
PACSIN2	0	DNM1	21	pull down	Modregger J (2000)	1
GAS7	0	KHDRBS1	1	pull down	Ingham RJ (2005)	1
PACSIN1	0	ASAP1	1	affinity chromatography technology	Linkermann A (2009)	1
GAS7	0	APBB1IP	1	pull down	Ingham RJ (2005)	1
PACSIN1	0	KAT7	3	two hybrid	Stelzl U (2005)	1
PACSIN2	0	APBB1IP	1	affinity chromatography technology	Linkermann A (2009)	1
PACSIN3	2	CARS	1	affinity chromatography technology	Linkermann A (2009)	1
POT1	2	HSPA1A	0	two hybrid	Lee OH (2011)	1
HTT	14	ITCH	1	imaging technique, affinity chromatography technology, affinity chromatography technology	Chhangani D (2014), Chhangani D (2014), Chhangani D (2014)	3
MYC	2	HSPA1A	0	affinity chromatography technology	Agrawal P (2010)	1
PACSIN3	2	CYFIP2	7	affinity chromatography technology	Linkermann A (2009)	1
MYC	2	PACSIN1	0	affinity chromatography technology	Hein MY (2015)	1
PPP2R1A	8	HSPA8	4	affinity chromatography technology	Aranda-Orgilles B (2008)	1
PACSIN2	0	WAS	0	affinity chromatography technology	Linkermann A (2009)	1
WASL	2	WIPF1	0	pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology	Zettl M (2002), Martinez-Quiles N (2001), Martinez-Quiles N (2001), Martinez-Quiles N (2001), Rolland T (2014), Huttlin EL (2017)	6
PACSIN1	0	COBLL1	3	two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Huttlin EL (2017)	2
PACSIN1	0	APBB1IP	1	affinity chromatography technology	Linkermann A (2009)	1
PACSIN2	0	COBL	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PACSIN2	0	WASL	2	pull down	Modregger J (2000)	1
PACSIN1	0	CST1	0	affinity chromatography technology	Huttlin EL (2017)	1
GAS7	0	WAS	0	pull down, affinity chromatography technology, affinity chromatography technology	Ingham RJ (2005), Tseng RC (2015), Tseng RC (2015)	3
PACSIN3	2	WASL	2	pull down	Modregger J (2000)	1
KAT7	3	JADE2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Huttlin EL (2015), Huttlin EL (2017)	3
PACSIN1	0	TRIOBP	8	affinity chromatography technology	Huttlin EL (2017)	1
WAS	0	WIPF1	0	two hybrid, affinity chromatography technology, pull down, two hybrid, two hybrid, two hybrid	Ramesh N (1997), Ramesh N (1997), Ramesh N (1997), Anton IM (1998), Wang J (2011), Rolland T (2014)	6
PACSIN3	2	SYNJ1	3	pull down	Modregger J (2000)	1
PACSIN1	0	MPRIP	2	affinity chromatography technology	Huttlin EL (2017)	1
KHDRBS1	1	POT1	2	two hybrid	Wang J (2011)	1
PACSIN1	0	EHBP1	4	two hybrid	Bandyopadhyay S (2010)	1
PACSIN2	0	CARS	1	affinity chromatography technology	Linkermann A (2009)	1
PPP2R1A	8	HSPA1A	0	affinity chromatography technology	Fogeron ML (2013)	1
HSPA8	4	HTT	14	pull down, affinity chromatography technology	Thompson LM (2009), Mitsui K (2002)	2
GAS7	0	CYFIP2	7	pull down	Ingham RJ (2005)	1
PACSIN1	0	SYNJ1	3	pull down	Modregger J (2000)	1
PACSIN1	0	WIPF1	0	affinity chromatography technology	Linkermann A (2009)	1
PACSIN3	2	COBL	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PACSIN2	0	SYNJ1	3	pull down	Modregger J (2000)	1
PACSIN1	0	RAI14	4	affinity chromatography technology	Huttlin EL (2017)	1
PPP2R1A	8	PACSIN1	0	affinity chromatography technology	Fogeron ML (2013)	1
PACSIN1	0	WASL	2	pull down	Modregger J (2000)	1
FTH1	0	CST1	0	affinity chromatography technology	Huttlin EL (2017)	1
PACSIN1	0	WAS	0	affinity chromatography technology	Linkermann A (2009)	1
PACSIN1	0	TPM4	0	two hybrid	Bandyopadhyay S (2010)	1
ARHGAP17	1	PACSIN1	0	pull down, two hybrid	Richnau N (2001), Bandyopadhyay S (2010)	2
PACSIN3	2	DNM1	21	pull down	Modregger J (2000)	1
PACSIN1	0	PACSIN1	0	two hybrid, pull down	Modregger J (2000), Modregger J (2000)	2
PACSIN1	0	MICALL1	1	affinity chromatography technology	Linkermann A (2009)	1
PACSIN3	2	KHDRBS1	1	affinity chromatography technology, biochemical	Linkermann A (2009), Wan C (2015)	2
PACSIN3	2	ASAP1	1	affinity chromatography technology	Linkermann A (2009)	1
PACSIN1	0	KHDRBS1	1	affinity chromatography technology, unspecified method	Linkermann A (2009), Asbach B (2012)	2
PACSIN1	0	PACSIN3	2	two hybrid, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology	Modregger J (2000), Modregger J (2000), Modregger J (2000), Modregger J (2000), Rolland T (2014), Huttlin EL (2017)	6
PACSIN1	0	JADE2	4	two hybrid	Bandyopadhyay S (2010)	1
DNM1	21	PACSIN1	0	affinity chromatography technology, pull down	Kamioka Y (2004), Modregger J (2000)	2
PACSIN3	2	RAI14	4	affinity chromatography technology	Huttlin EL (2017)	1
PACSIN3	2	HSPA8	4	affinity chromatography technology	Linkermann A (2009)	1
PACSIN3	2	APBB1IP	1	affinity chromatography technology	Linkermann A (2009)	1
PACSIN1	0	HSPA1A	0	affinity chromatography technology	Linkermann A (2009)	1
PACSIN1	0	ATP8	0	two hybrid	Bandyopadhyay S (2010)	1
PACSIN1	0	DNM2	2	affinity chromatography technology	Linkermann A (2009)	1
PACSIN1	0	CYFIP2	7	affinity chromatography technology	Linkermann A (2009)	1
SYNM	3	PACSIN1	0	affinity chromatography technology	Anggono V (2007)	1