PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE3A	4	PSMD3	5	affinity chromatography technology	Jung SY (2005)	1
BAG6	2	EFEMP2	0	two hybrid	Rual JF (2005)	1
UBQLN1	1	APP	1	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Stieren ES (2011), Stieren ES (2011), Hiltunen M (2006)	3
APP	1	PSEN1	11	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
UBQLN1	1	UBXN1	0	biochemical, two hybrid	Havugimana PC (2012), Rolland T (2014)	2
PSMD4	1	UBXN1	0	affinity chromatography technology	McNeill H (2004)	1
UBQLN2	0	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chang L (2015), Hjerpe R (2016), Hjerpe R (2016)	3
ZMYM4	4	UBQLN4	2	affinity chromatography technology	Hauri S (2016)	1
SERPINI2	0	BAG6	2	two hybrid	Yu H (2011)	1
UBQLN4	2	KLHL42	1	two hybrid	Lim J (2006)	1
RAD23B	1	UBQLN1	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
HERPUD1	2	UBQLN4	2	affinity chromatography technology, affinity chromatography technology	Kim TY (2008), Kim TY (2008)	2
UBQLN1	1	UBQLN1	1	two hybrid, two hybrid, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Ford DL (2006), Ford DL (2006), Ford DL (2006), Lim J (2006), Rolland T (2014), Kurlawala Z (2017)	7
GABRD	3	UBQLN1	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UBQLN4	2	HGS	5	two hybrid	Lim J (2006)	1
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
UBQLN4	2	RIC8A	4	two hybrid	Lim J (2006)	1
UBQLN1	1	GABRB3	19	affinity chromatography technology, two hybrid	Bedford FK (2001), Bedford FK (2001)	2
RAD23A	1	UBC	7	pull down, pull down, x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, unspecified method, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, pull down, x-ray crystallography, pull down, pull down	Kang Y (2006), Sims JJ (2009), Kang Y (2007), Kang Y (2007), Wang Q (2003), Scanlon TC (2009), Raasi S (2003), Sokratous K (2012), Varadan R (2005), Fenner BJ (2009), Raasi S (2005), Massey LK (2004), Chen L (2006), Nathan JA (2013), Nathan JA (2013), Jung J (2014), Goh AM (2008), Castaneda CA (2013), Nakasone MA (2013), Lai MY (2012), Kristariyanto YA (2015), Zhang X (2017)	22
ADRM1	4	UBC	7	x-ray crystallography, pull down, two hybrid, pull down, pull down, x-ray crystallography, pull down	Schreiner P (2008), Hennig J (2012), Husnjak K (2008), Sahtoe DD (2015), Chen X (2016), Chen X (2016), Zhang X (2017)	7
CSTF2T	4	UBQLN1	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UBXN1	0	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Wu-Baer F (2010), Fenner BJ (2009), Alexandru G (2008), LaLonde DP (2011), McNeill H (2004), Zhang X (2017)	6
UBE3A	4	UBQLN1	1	two hybrid, affinity chromatography technology	Kleijnen MF (2000), Kleijnen MF (2000)	2
UBQLN4	2	UBQLN2	0	two hybrid	Lim J (2006)	1
HERPUD1	2	UBQLN1	1	affinity chromatography technology, affinity chromatography technology	Kim TY (2008), Kim TY (2008)	2
HGS	5	UBQLN1	1	two hybrid, affinity chromatography technology	Rual JF (2005), Regan-Klapisz E (2005)	2
HGS	5	APP	1	pull down, pull down, pull down	Pridgeon JW (2009), Olah J (2011), Virok DP (2011)	3
ADRM1	4	PSMD4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hamazaki J (2006), Jorgensen JP (2006), Jorgensen JP (2006), Berko D (2014), Huttlin EL (2015), Huttlin EL (2017), Sparks A (2014)	7
CSTF2	2	APP	1	pull down	Olah J (2011)	1
UBQLN4	2	MAP1LC3A	0	affinity chromatography technology	Lee DY (2013)	1
CSTF2	2	BAG6	2	two hybrid	Stelzl U (2005)	1
PLA2G16	1	UBQLN1	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UBE3A	4	UBQLN2	0	two hybrid, biochemical, affinity chromatography technology	Kleijnen MF (2000), Kleijnen MF (2000), Kleijnen MF (2000)	3
RAD23A	1	UBQLN1	1	x-ray crystallography, affinity chromatography technology, biochemical	Kang Y (2007), Kang Y (2007), Wan C (2015)	3
VCP	6	MTOR	14	affinity chromatography technology	Yu CC (2013)	1
PSMD3	5	PSMD4	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
UBQLN2	0	RAD23A	1	biochemical	Wan C (2015)	1
PSEN1	11	PSEN2	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Gu Y (2003), Soler-Lopez M (2011), Hebert SS (2004), Hebert SS (2004)	4
BAG6	2	VCP	6	affinity chromatography technology, affinity chromatography technology, biochemical	Wang Q (2011), Yu CC (2013), Xu Y (2013)	3
VCP	6	PSMD4	1	affinity chromatography technology, affinity chromatography technology	Arrojo E Drigo R (2013), McNeill H (2004)	2
CSTF2	2	CSTF2T	4	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
RARA	5	UBQLN1	1	two hybrid, pull down	Zhu D (2010), Zhu D (2010)	2
UBE3A	4	APP	1	pull down	Olah J (2011)	1
HSPA13	1	UBQLN2	0	two hybrid	Kaye FJ (2000)	1
UBQLN1	1	ESYT2	2	affinity chromatography technology, affinity chromatography technology	Kurlawala Z (2017), Kurlawala Z (2017)	2
TARDBP	4	APP	1	pull down	Olah J (2011)	1
UBQLN1	1	AGR3	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
UBQLN1	1	EPS15	1	pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Heir R (2006), Heir R (2006), Regan-Klapisz E (2005), Regan-Klapisz E (2005), NDiaye EN (2008)	5
TARDBP	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gitcho MA (2009), Gitcho MA (2009), Freibaum BD (2010)	3
HSPA13	1	UBQLN1	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Wang J (2011), Rolland T (2014)	3
HERC3	0	UBQLN2	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Hochrainer K (2008), Hochrainer K (2008), Hochrainer K (2008)	3
UBQLN2	0	UBQLN1	1	two hybrid, affinity chromatography technology	Ford DL (2006), Ford DL (2006)	2
UBQLN4	2	PNMA1	0	two hybrid	Lim J (2006)	1
PSMD4	1	APP	1	pull down	Olah J (2011)	1
UBQLN4	2	HSPA13	1	two hybrid	Lim J (2006)	1
PSEN1	11	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
PNMA1	0	UBQLN1	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
MAP1LC3A	0	UBC	7	biochemical, imaging technique	Fujita N (2013), Govindaraju VK (2017)	2
HERPUD1	2	UBQLN2	0	affinity chromatography technology, affinity chromatography technology	Kim TY (2008), Kim TY (2008)	2
UBQLN1	1	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lim PJ (2009), Yu CC (2013), Lim PJ (2009), Lim PJ (2009)	4
HERPUD1	2	VCP	6	biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Schulze A (2005), Schulze A (2005), Schulze A (2005), Schulze A (2005)	4
RAD23A	1	RAD23B	1	biochemical, affinity chromatography technology	van der Spek PJ (1996), Hsieh HC (2005)	2
UBQLN1	1	MAP1LC3A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rothenberg C (2010), Rothenberg C (2010), Lee DY (2013)	3
UBE3A	4	ADRM1	4	enzymatic study	Jacobson AD (2014)	1
RAD23B	1	PSMC2	2	affinity chromatography technology, biochemical, biochemical, pull down	Chen L (2006), Havugimana PC (2012), Wan C (2015), Sun S (2017)	4
VCP	6	APP	1	affinity chromatography technology	Jang JK (2017)	1
UBQLN1	1	P4HB	1	two hybrid, affinity chromatography technology, pull down	Ko HS (2002), Ko HS (2002), Ko HS (2002)	3
ADRM1	4	APP	1	pull down	Olah J (2011)	1
UBXN4	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Alexandru G (2008), Lim PJ (2009), Liang J (2006), Lim PJ (2009), Madsen L (2014), Raman M (2015)	6
TREX1	0	UBQLN1	1	affinity chromatography technology, pull down	Orebaugh CD (2013), Orebaugh CD (2013)	2
HERPUD1	2	APP	1	pull down	Olah J (2011)	1
PSMC2	2	UBC	7	pull down, pull down	Jacobson AD (2014), Zhang X (2017)	2
TRIM32	2	UBC	7	enzymatic study, pull down	Streich FC (2013), Zhang X (2017)	2
RTL8C	0	APP	1	pull down	Olah J (2011)	1
GABRB2	8	GABRB3	19	affinity chromatography technology	Huttlin EL (2017)	1
IGF1R	5	APP	1	pull down	Olah J (2011)	1
P4HB	1	VCP	6	biochemical	Wan C (2015)	1
CSTF2	2	HGS	5	two hybrid	Rolland T (2014)	1
RAD23A	1	ADRM1	4	affinity chromatography technology	Scanlon TC (2009)	1
UBQLN1	1	HERC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hochrainer K (2008), Hochrainer K (2015), Hochrainer K (2015)	3
UBC	7	PSMD4	1	pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Fallon L (2006), Wang Q (2005), Leonchiks A (2002), Isasa M (2010), Wang Q (2005), Wang Q (2005), Haririnia A (2007), Fenner BJ (2009), Raasi S (2005), Nathan JA (2013), Beal R (1996), Uchiki T (2009), Young P (1998), Fujiwara K (2004), Dimitrov S (2005), Yoshimoto N (2009), Hawryluk MJ (2006), Nakayasu ES (2013), Nakayasu ES (2013), Tomaic V (2015), Aguileta MA (2015), Zhang X (2017), Kristariyanto YA (2017)	23
MAP1LC3A	0	RASSF5	2	affinity chromatography technology	Behrends C (2010)	1
UBQLN1	1	PRAP1	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
RAD23B	1	PSMD4	1	two hybrid, pull down, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, biochemical	Hiyama H (1999), Hiyama H (1999), Ryu KS (2003), Fatimababy AS (2010), Fatimababy AS (2010), Fujiwara K (2004), Wan C (2015)	7
PSMD3	5	ADRM1	4	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
UBQLN1	1	RIC8A	4	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Lim J (2006), Rolland T (2014), Yu H (2011)	4
IGF1R	5	MTOR	14	genetic interference	Shen JP (2017)	1
UBQLN1	1	ADRM1	4	affinity chromatography technology, pull down, two hybrid	Fatimababy AS (2010), Fatimababy AS (2010), Lim J (2006)	3
UBXN1	0	UBE3A	4	affinity chromatography technology	Alexandru G (2008)	1
UBE3A	4	UBC	7	enzymatic study, enzymatic study, pull down	Schwarz SE (1998), Ronchi VP (2013), Zhang X (2017)	3
BAG6	2	UBXN1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015), Raman M (2015)	3
UBQLN1	1	RASSF5	2	two hybrid, two hybrid	Lim J (2006), Rolland T (2014)	2
PSEN1	11	HERPUD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sai X (2002), Sai X (2003), Sai X (2003)	3
UBQLN1	1	GABRB2	8	affinity chromatography technology, two hybrid	Bedford FK (2001), Bedford FK (2001)	2
RTL8A	0	UBQLN1	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UBXN1	0	UBE4B	5	affinity chromatography technology	Alexandru G (2008)	1
UBQLN4	2	3537	0	two hybrid	Lim J (2006)	1
UBQLN1	1	RTL8C	0	two hybrid, two hybrid	Lim J (2006), Rolland T (2014)	2
UBQLN4	2	TRIM32	2	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
RAD23B	1	ADRM1	4	affinity chromatography technology, pull down	Fatimababy AS (2010), Fatimababy AS (2010)	2
BAG6	2	MTOR	14	affinity chromatography technology	Hein MY (2015)	1
GABRA1	6	VCP	6	affinity chromatography technology	Di XJ (2016)	1
MAP1LC3A	0	APP	1	pull down	Olah J (2011)	1
HK2	3	UBQLN1	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UBQLN1	1	MTOR	14	two hybrid, affinity chromatography technology, two hybrid	Wu S (2002), Wu S (2002), Wu S (2002)	3
RAD23A	1	PSMC2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Scanlon TC (2009), Chen L (2006), Tsai NP (2012), Wan C (2015)	4
PSMD4	1	MAP1LC3A	0	affinity chromatography technology	Lee DY (2013)	1
UBC	7	RTL8C	0	pull down	Zhang X (2017)	1
RAD23A	1	EPS15	1	affinity chromatography technology	Scanlon TC (2009)	1
UBQLN1	1	BAG6	2	affinity chromatography technology, affinity chromatography technology	Kurlawala Z (2017), Kurlawala Z (2017)	2
UBQLN4	2	SERPINI2	0	two hybrid	Lim J (2006)	1
RAD23A	1	PSMD4	1	two hybrid, pull down, x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Hiyama H (1999), Mueller TD (2003), Kang Y (2007), Kang Y (2007), Wang Q (2003), Walters KJ (2003), Walters KJ (2002), Scanlon TC (2009), Hsieh HC (2005)	9
EPS15	1	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Woelk T (2006), De Schutter J (2009), Brehme M (2009), Hoeller D (2006), Zhang X (2017), Kristariyanto YA (2017)	6
SERPINI2	0	UBQLN1	1	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Lim J (2006), Rolland T (2014), Yu H (2011)	4
UBQLN4	2	BAG6	2	two hybrid, affinity chromatography technology	Lim J (2006), Suzuki R (2016)	2
UBC	7	PSMD3	5	pull down	Zhang X (2017)	1
UBE4B	5	UBQLN1	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
RAD23A	1	PSMD3	5	affinity chromatography technology	Scanlon TC (2009)	1
UBQLN1	1	GABRA1	6	affinity chromatography technology, two hybrid	Bedford FK (2001), Bedford FK (2001)	2
TRIM32	2	UBQLN1	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UBE4B	5	RAD23A	1	pull down	Goh AM (2008)	1
UBQLN1	1	TMCO6	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
PSMD4	1	UBQLN4	2	pull down, affinity chromatography technology, affinity chromatography technology	Riley BE (2004), Li X (2008), Su V (2013)	3
UBQLN4	2	UBXN1	0	biochemical	Havugimana PC (2012)	1
EPS15	1	HGS	5	pull down, two hybrid, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Bean AJ (2000), Bean AJ (2000), Bache KG (2003), Roxrud I (2008), Roxrud I (2008), Yan Q (2005), Gschweitl M (2016)	7
UBQLN1	1	IGF1R	5	affinity chromatography technology, affinity chromatography technology	Kurlawala Z (2017), Kurlawala Z (2017)	2
UBQLN4	2	UBC	7	pull down	Su V (2010)	1
UBC	7	UBQLN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, two hybrid, pull down, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Matsumoto M (2005), Ko HS (2004), Ko HS (2004), Sokratous K (2012), Raasi S (2005), Raasi S (2005), Massey LK (2004), Ko HS (2004), Ko HS (2004), Rolland T (2014), Castaneda CA (2013), Nakayasu ES (2013), Nakayasu ES (2013), Kristariyanto YA (2015), Kristariyanto YA (2015), Kurlawala Z (2017)	16
RAD23B	1	UBE3A	4	pull down, enzymatic study	Kumar S (1999), Kumar S (1999)	2
UBC	7	RAD23B	1	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Ryu KS (2003), Chen L (2006), Nathan JA (2013), Nathan JA (2013), Nakayasu ES (2013), Nakayasu ES (2013), Kristariyanto YA (2015), Zhang X (2017)	9
UBQLN1	1	TARDBP	4	two hybrid, pull down	Kim SH (2009), Kim SH (2009)	2
UBQLN4	2	MIEF2	4	two hybrid	Lim J (2006)	1
UBQLN1	1	UBXN4	0	two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Lim PJ (2009), Lim PJ (2009), Lim PJ (2009), Rolland T (2014), Lim PJ (2009)	5
UBQLN1	1	PSEN1	11	two hybrid, pull down, fluorescent resonance energy transfe, pull down	Mah AL (2000), Mah AL (2000), Thomas AV (2006), Ford DL (2006)	4
HERC3	0	PSMD4	1	affinity chromatography technology, affinity chromatography technology	Hochrainer K (2015), Hochrainer K (2015)	2
UBE4B	5	VCP	6	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsumoto M (2004), Matsumoto M (2004), Boehm S (2011), Takahata M (2008), Morreale G (2009), Fernandez-Saiz V (2010), Fernandez-Saiz V (2010), Raman M (2015), Wang T (2016), Huttlin EL (2017)	10
EPS15L1	1	UBQLN1	1	two hybrid, affinity chromatography technology	Regan-Klapisz E (2005), Regan-Klapisz E (2005)	2
UBQLN1	1	PSEN2	3	two hybrid, pull down, two hybrid, pull down, pull down	Mah AL (2000), Mah AL (2000), Ford DL (2007), Ford DL (2007), Ford DL (2006)	5
UBQLN4	2	EFEMP2	0	two hybrid	Lim J (2006)	1
UBQLN1	1	PSMD4	1	pull down, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Fallon L (2006), Heir R (2006), Ko HS (2004), Walters KJ (2002), Fatimababy AS (2010), Fatimababy AS (2010), Ko HS (2004), Ko HS (2004), Kurlawala Z (2017), Kurlawala Z (2017)	10
PSEN1	11	UBC	7	imaging technique	Gudey SK (2014)	1
UBQLN4	2	CSTF2T	4	two hybrid	Lim J (2006)	1
RAD23A	1	VCP	6	affinity chromatography technology	Laco MN (2012)	1
UBQLN2	0	EPS15	1	affinity chromatography technology	NDiaye EN (2008)	1
PSMC2	2	PSMD3	5	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
ZMYM4	4	UBQLN1	1	two hybrid, biochemical	Rolland T (2014), Wan C (2015)	2
UBQLN1	1	ZG16	0	two hybrid, two hybrid	Lim J (2006), Rolland T (2014)	2
HGS	5	UBC	7	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Mizuno E (2006), Raiborg C (2002), Raiborg C (2002), Nathan JA (2013), Nathan JA (2013), Bishop N (2002), Stuible M (2010), Oved S (2006), Hoeller D (2006), Kharitidi D (2015), Zhang X (2017)	11
PSMC2	2	PSMD4	1	biochemical, biochemical, biochemical, biochemical, pull down, biochemical, affinity chromatography technology	Kim YC (2011), Shim SM (2012), Havugimana PC (2012), Kristensen AR (2012), Berko D (2014), Wan C (2015), Sun S (2017)	7
UBQLN4	2	RAD23A	1	two hybrid, biochemical	Lim J (2006), Wan C (2015)	2
VCP	6	UBXN1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), McNeill H (2004), LaLonde DP (2011), LaLonde DP (2011), LaLonde DP (2011), LaLonde DP (2011), Rolland T (2014), McNeill H (2004), Raman M (2015), Park ES (2017)	11
UBQLN2	0	PSMC2	2	pull down	Aguileta MA (2015)	1
BAG6	2	NBL1	1	two hybrid	Ozaki T (1999)	1
BAG6	2	HSPA13	1	two hybrid	Wang J (2011)	1
APP	1	PSEN2	3	two hybrid	Soler-Lopez M (2011)	1
UBE3A	4	PSMD4	1	enzymatic study, biochemical, enzymatic study, enzymatic study, pull down	Uchiki T (2009), Martinez-Noel G (2012), Kim HT (2012), Jacobson AD (2014), Tomaic V (2015)	5
UBQLN1	1	BCL2L10	0	affinity chromatography technology, affinity chromatography technology	Beverly LJ (2012), Kurlawala Z (2017)	2
TICAM1	3	UBQLN1	1	affinity chromatography technology, pull down	Biswas N (2011), Biswas N (2011)	2
UBQLN4	2	HK2	3	two hybrid	Lim J (2006)	1
HERPUD1	2	UBC	7	affinity chromatography technology	Sai X (2003)	1
3537	0	UBQLN1	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
HGS	5	CSTF2T	4	two hybrid	Rolland T (2014)	1
VCP	6	MAP1LC3A	0	imaging technique	Wang Y (2011)	1
HGS	5	UBE4B	5	pull down	Sirisaengtaksin N (2014)	1
PSMC2	2	UBQLN1	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Hochrainer K (2015)	2
RAD23A	1	UBE3A	4	pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, two hybrid	Kumar S (1999), Kumar S (1999), Scanlon TC (2009), Kuehnle S (2013), Kumar S (1997), Mortensen F (2015), Kim HT (2007), Cooper EM (2004), Cooper EM (2004)	9
RTL8A	0	APP	1	pull down	Olah J (2011)	1
RARA	5	TRIM32	2	affinity chromatography technology, affinity chromatography technology	Sato T (2011), Sato T (2011)	2
UBQLN1	1	PSMD3	5	pull down, affinity chromatography technology	Ko HS (2004), Ko HS (2004)	2
UBQLN4	2	CSTF2	2	two hybrid	Lim J (2006)	1
UBQLN1	1	KLHL42	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UBQLN4	2	GABRD	3	two hybrid	Lim J (2006)	1
UBQLN1	1	EFEMP2	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Lim J (2006), Rolland T (2014)	3
RAD23B	1	UBE4B	5	affinity chromatography technology	Huttlin EL (2017)	1
UBQLN2	0	TARDBP	4	pull down, affinity chromatography technology	Cassel JA (2013), Cassel JA (2013)	2
UBQLN4	2	ZG16	0	two hybrid	Lim J (2006)	1
UBQLN4	2	UBQLN1	1	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Lim J (2006), Havugimana PC (2012), Lee DY (2013), Lee DY (2013)	4
HERC3	0	PSMC2	2	affinity chromatography technology, affinity chromatography technology	Hochrainer K (2015), Hochrainer K (2015)	2
UBE3A	4	RARA	5	two hybrid	Lim J (2006)	1
UBQLN1	1	MIEF2	4	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ADRM1	4	UBQLN2	0	pull down, x-ray crystallography	Chen X (2016), Chen X (2016)	2
PSMC2	2	ADRM1	4	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
UBQLN2	0	RAD23B	1	biochemical	Wan C (2015)	1
UBQLN2	0	P4HB	1	biochemical	Kristensen AR (2012)	1
UBQLN4	2	PLA2G16	1	two hybrid	Lim J (2006)	1
UBC	7	EPS15L1	1	pull down	Zhang X (2017)	1
NBL1	1	UBQLN1	1	two hybrid, two hybrid	Ozaki T (1997), Rolland T (2014)	2
UBQLN4	2	RAD23B	1	biochemical	Wan C (2015)	1
CSTF2	2	UBQLN1	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UBC	7	HERC3	0	pull down	Cruz C (2001)	1