Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
NR3C1 2908 PREDNICARBATE CHEMBL1200386 agonist TdgClinicalTrial, ChemblInteractions, DrugBank 19482847, 2879901
NR3C1 2908 CORT 125134 CHEMBL3544957 antagonist ChemblInteractions
NR3C1 2908 DIFLORASONE DIACETATE CHEMBL1200545 agonist GuideToPharmacologyInteractions, ChemblInteractions
NR3C1 2908 BECLOMETHASONE DIPROPIONATE CHEMBL1200500 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 15860753, 16507850, 12010562
NR3C1 2908 MIFEPRISTONE CHEMBL1276308 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 15120421, 15336699, 16723527, 15909120, 10796070
NR3C1 2908 MOMETASONE CHEMBL1201404 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, TTD
NR3C1 2908 DESONIDE CHEMBL1201109 agonist TdgClinicalTrial, DrugBank, ChemblInteractions 20371666, 17038445, 20427668
NR3C1 2908 ORG-34517 CHEMBL3545391 antagonist ChemblInteractions, DrugBank, TTD
NR3C1 2908 CLOBETASONE BUTYRATE CHEMBL2308885 agonist DrugBank
NR3C1 2908 HYDROCORTISONE SODIUM SUCCINATE CHEMBL1200495 agonist ChemblInteractions
NR3C1 2908 FLUMETHASONE PIVALATE CHEMBL1200877 agonist TdgClinicalTrial, ChemblInteractions, TEND
NR3C1 2908 HYDROCORTISONE ACETATE CHEMBL1091 agonist ChemblInteractions
NR3C1 2908 MOMETASONE FUROATE CHEMBL1161 agonist ChemblInteractions
NR3C1 2908 HYDROCORTISONE BUTYRATE CHEMBL1683 agonist ChemblInteractions
NR3C1 2908 FLUPREDNISOLONE CHEMBL1200774 agonist ChemblInteractions
NR3C1 2908 ALCLOMETASONE CHEMBL1201361 TdgClinicalTrial
NR3C1 2908 DIFLORASONE CHEMBL1201380 TdgClinicalTrial
NR3C1 2908 TRIAMCINOLONE HEXACETONIDE CHEMBL1200878 agonist ChemblInteractions
NR3C1 2908 MEDRYSONE CHEMBL1201173 agonist, binder TdgClinicalTrial, ChemblInteractions, DrugBank, TTD 6336597, 11752352
NR3C1 2908 AMCINONIDE CHEMBL1200732 agonist TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 17038445, 17139284, 17016423, 16980198, 16895953, 17086345, 16891588
NR3C1 2908 MEGESTROL ACETATE CHEMBL1201139 agonist DrugBank 2982481, 9744490, 6222739, 9195366, 15595341, 18411198
NR3C1 2908 SPIRONOLACTONE CHEMBL1393 antagonist DrugBank 20650892
NR3C1 2908 FLURANDRENOLIDE CHEMBL1201012 agonist TdgClinicalTrial, ChemblInteractions, DrugBank 20346397, 16507850, 16255837
NR3C1 2908 RIMEXOLONE CHEMBL1200617 agonist TdgClinicalTrial, ChemblInteractions, DrugBank 2386110
NR3C1 2908 BUDESONIDE CHEMBL1370 agonist, antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank, TTD 11730731, 11040338, 12920235, 12601049, 11752352, 11258648
NR3C1 2908 DESOXYCORTICOSTERONE CHEMBL1498 agonist GuideToPharmacologyInteractions
NR3C1 2908 FLUTICASONE PROPIONATE CHEMBL1473 agonist, antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, TTD
NR3C1 2908 DEXMEDETOMIDINE CHEMBL778 agonist GuideToPharmacologyInteractions
NR3C1 2908 BETAMETHASONE CHEMBL632 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, TTD
NR3C1 2908 ONAPRISTONE CHEMBL1908373 antagonist GuideToPharmacologyInteractions
NR3C1 2908 VAMOROLONE CHEMBL3707311 GuideToPharmacologyInteractions
NR3C1 2908 CORTISONE ACETATE CHEMBL1650 agonist ChemblInteractions, DrugBank 17038445, 16980198, 16895953, 7062741, 17086345, 7054210, 16891588
NR3C1 2908 STAUROSPORINE CHEMBL388978 NCI 9751175
NR3C1 2908 HALCINONIDE CHEMBL1200845 agonist ChemblInteractions
NR3C1 2908 LOTEPREDNOL ETABONATE CHEMBL1200865 agonist, binder TdgClinicalTrial, ChemblInteractions, TEND, TTD
NR3C1 2908 METHYLPREDNISOLONE SODIUM SUCCINATE CHEMBL1201081 agonist ChemblInteractions
NR3C1 2908 BETAMETHASONE BENZOATE CHEMBL1200376 agonist ChemblInteractions
NR3C1 2908 HYDROCORTISONE PROBUTATE CHEMBL1200953 agonist ChemblInteractions
NR3C1 2908 GALSULFASE CHEMBL1201822 agonist TTD
NR3C1 2908 CLOCORTOLONE ACETATE CHEMBL2106011 TdgClinicalTrial
NR3C1 2908 CLOBETASOL CHEMBL1201362 TdgClinicalTrial
NR3C1 2908 PREDNISOLONE TEBUTATE CHEMBL1200909 agonist ChemblInteractions
NR3C1 2908 DEFLAZACORT CHEMBL1201891 agonist ChemblInteractions
NR3C1 2908 CORT 108297 CHEMBL271220 antagonist TdgClinicalTrial, ChemblInteractions
NR3C1 2908 MEPREDNISONE CHEMBL1201148 agonist ChemblInteractions
NR3C1 2908 DESOXIMETASONE CHEMBL1766 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 17038445, 10754457, 16980198, 16895953, 17086345, 16891588
NR3C1 2908 HALOBETASOL PROPIONATE CHEMBL1200908 agonist TdgClinicalTrial, ChemblInteractions, DrugBank 19293512, 9891987
NR3C1 2908 DEXAMETHASONE CHEMBL384467 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, TTD
NR3C1 2908 METHYLPREDNISOLONE CHEMBL650 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, TTD
NR3C1 2908 PREDNISOLONE CHEMBL131 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND
NR3C1 2908 TRIAMCINOLONE CHEMBL1451 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions
NR3C1 2908 DAGROCORAT CHEMBL3137304 agonist, modulator GuideToPharmacologyInteractions, ChemblInteractions
NR3C1 2908 FOSDAGROCORAT CHEMBL3137316 agonist, modulator GuideToPharmacologyInteractions, ChemblInteractions
NR3C1 2908 1,6-HEXANEDIOL CHEMBL458616 DrugBank 17139284, 17016423
NR3C1 2908 ULIPRISTAL CHEMBL2103846 antagonist DrugBank 23437846
NR3C1 2908 FLUTICASONE FUROATE CHEMBL1676 agonist TdgClinicalTrial, ChemblInteractions, DrugBank, TTD
NR3C1 2908 ESTRADIOL CHEMBL135 NCI 12553866
NR3C1 2908 BETAMETHASONE DIPROPIONATE CHEMBL1200384 agonist ChemblInteractions
NR3C1 2908 FLUOROMETHOLONE ACETATE CHEMBL1201064 agonist ChemblInteractions
NR3C1 2908 TRIAMCINOLONE DIACETATE CHEMBL1200449 agonist ChemblInteractions
NR3C1 2908 PREDNISOLONE SODIUM PHOSPHATE CHEMBL1201014 agonist ChemblInteractions
NR3C1 2908 BETAMETHASONE VALERATE CHEMBL1497 agonist ChemblInteractions
NR3C1 2908 METHYLPREDNISOLONE ACETATE CHEMBL1200844 agonist ChemblInteractions
NR3C1 2908 BECLOMETHASONE CHEMBL1586 TdgClinicalTrial
NR3C1 2908 HYDROCORTISONE VALERATE CHEMBL1200562 agonist ChemblInteractions
NR3C1 2908 BETAMETHASONE ACETATE CHEMBL1200538 agonist ChemblInteractions
NR3C1 2908 MAPRACORAT CHEMBL2103876 agonist GuideToPharmacologyInteractions, ChemblInteractions
NR3C1 2908 FLUOCINOLONE ACETONIDE CHEMBL989 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 19744340
NR3C1 2908 FLUOROMETHOLONE CHEMBL1200600 agonist, binder TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, DrugBank, TTD 17038445, 16980198, 16895953, 17086345, 16891588, 15684812
NR3C1 2908 FLUNISOLIDE CHEMBL1512 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank, TTD 15285788, 9563368, 9523318, 11752352, 2386110, 8466638, 11368283
NR3C1 2908 PREDNISONE CHEMBL635 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank, TTD 17062674, 11752352, 17504182, 16707595, 17121036, 16597193
NR3C1 2908 FLUMETHASONE CHEMBL1201392 agonist DrugBank 20920967, 16079279, 17139284, 17016423
NR3C1 2908 HYDROCORTAMATE CHEMBL1201263 agonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
NR3C1 2908 LOTEPREDNOL CHEMBL1201389 agonist DrugBank 17020532, 15684812, 11752352, 2004037, 12861354
NR3C1 2908 FLUOXYMESTERONE CHEMBL1445 antagonist DrugBank 173192
NR3C1 2908 HYDROCORTISONE CHEMBL389621 agonist GuideToPharmacologyInteractions, ChemblInteractions
NR3C1 2908 FLUTICASONE CHEMBL1201396 agonist, antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TTD
NR3C1 2908 TRIAMCINOLONE ACETONIDE CHEMBL1504 agonist GuideToPharmacologyInteractions, ChemblInteractions
NR3C1 2908 CHEMBL216272 CHEMBL216272 agonist GuideToPharmacologyInteractions
NR3C1 2908 PARAMETHASONE CHEMBL1579 agonist TdgClinicalTrial, DrugBank 17038445, 16980198, 16895953, 17086345, 16891588, 16255837
NR3C1 2908 METHOTREXATE CHEMBL34259 NCI 12210990
NR3C1 2908 HYDROCORTAMATE HYDROCHLORIDE CHEMBL1200635 agonist ChemblInteractions
NR3C1 2908 PARAMETHASONE ACETATE CHEMBL1200342 agonist ChemblInteractions
NR3C1 2908 DEXAMETHASONE SODIUM PHOSPHATE CHEMBL1200637 agonist ChemblInteractions
NR3C1 2908 HYDROCORTISONE SODIUM PHOSPHATE CHEMBL1200968 agonist ChemblInteractions
NR3C1 2908 ALCLOMETASONE DIPROPIONATE CHEMBL1200989 agonist ChemblInteractions
NR3C1 2908 DEXAMETHASONE ACETATE CHEMBL1651 agonist ChemblInteractions
NR3C1 2908 PREDNISOLONE ACETATE CHEMBL1152 agonist ChemblInteractions
NR3C1 2908 HYDROCORTISONE CYPIONATE CHEMBL1549 agonist ChemblInteractions
NR3C1 2908 BETAMETHASONE SODIUM PHOSPHATE CHEMBL1200762 agonist ChemblInteractions
NR3C1 2908 CLOCORTOLONE PIVALATE CHEMBL1200975 agonist ChemblInteractions, DrugBank 18691892, 18022656, 12188035
NR3C1 2908 ANDROSTENEDIONE CHEMBL274826 NCI 9384522
NR3C1 2908 CLOBETASOL PROPIONATE CHEMBL1159650 agonist GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 16255837, 9891987
NR3C1 2908 CICLESONIDE CHEMBL2040682 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 17530144
NR3C1 2908 FLUOCINONIDE CHEMBL1501 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 11279785
NR3C1 2908 DIFLUPREDNATE CHEMBL1201749 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank 19668594, 20509750

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
NR3C1 rs6196 G prednisone efficacy yes This variant was also part of a haplotype of three variants (rs10052957, rs258751 and rs6196) associated with steroid resistance. There were no GG individuals in the resistant group/cases. Allele G is associated with decreased resistance to prednisone in people with Nephrotic Syndrome as compared to allele A. 29207898 1449163673
NR3C1 rs258751 A prednisone efficacy yes This variant was also part of a haplotype of three variants (rs10052957, rs258751 and rs6196) associated with steroid resistance. There were no AA individuals in the resistant group/cases. Allele A is associated with decreased resistance to prednisone in people with Nephrotic Syndrome as compared to allele G. 29207898 1449163647
NR3C1 rs10052957 A prednisone efficacy yes This variant was also part of a haplotype of three variants (rs10052957, rs258751 and rs6196) associated with steroid resistance. There were no AA individuals in the resistant group/cases. Allele A is associated with decreased resistance to prednisone in people with Nephrotic Syndrome as compared to allele G. 29207898 1449163663