PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DLG3	1	EXOC4	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Sans N (2003), Sans N (2003), Sans N (2003), Sans N (2003)	4
CAMK2G	4	GRIN1	13	enzymatic study	Wechsler A (1998)	1
CAMK2A	6	CAMK2G	4	affinity chromatography technology	So J (2015)	1
RACK1	2	GRIN2B	30	affinity chromatography technology	Yaka R (2003)	1
RACK1	2	FYN	1	affinity chromatography technology, pull down, affinity chromatography technology	Yaka R (2003), Yaka R (2002), Yaka R (2002)	3
GRIN2B	30	MIB2	7	affinity chromatography technology, pull down	Jurd R (2008), Jurd R (2008)	2
GRIN2B	30	FYN	1	pull down, enzymatic study	Takagi N (1999), Wechsler A (1998)	2
GRIN2B	30	SPTAN1	9	biochemical, pull down	Wechsler A (1998), Wechsler A (1998)	2
PRKCA	7	RACK1	2	affinity chromatography technology	Lee HS (2002)	1
PRKN	1	CAMK2A	6	affinity chromatography technology	Fallon L (2002)	1
CAPN1	3	GRIN2B	30	imaging technique	Chen TC (2014)	1
DLG4	11	ACTN2	2	pull down	Eldstrom J (2002)	1
CAMK2A	6	DLG1	2	affinity chromatography technology, enzymatic study	Gardoni F (2003), Gardoni F (2003)	2
GRIN2B	30	EXOC3	2	affinity chromatography technology	Sans N (2003)	1
GRIN2B	30	EXOC4	2	affinity chromatography technology, affinity chromatography technology	Sans N (2003), Sans N (2003)	2
FYN	1	GRIN1	13	enzymatic study	Wechsler A (1998)	1
EXOC3	2	EXOC4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sans N (2003), Sans N (2003), Inoue M (2003), Havugimana PC (2012), Andersen NJ (2010), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	8
FYN	1	ARHGAP32	11	two hybrid, pull down, affinity chromatography technology	Taniguchi S (2003), Taniguchi S (2003), Taniguchi S (2003)	3
PRKN	1	GRIN2B	30	affinity chromatography technology, imaging technique	Fallon L (2002), Chen TC (2014)	2
ACTN2	2	DLG1	2	affinity chromatography technology, affinity chromatography technology	Eldstrom J (2003), Eldstrom J (2003)	2
EXOC3	2	EXOC7	3	biochemical, affinity chromatography technology, affinity chromatography technology	Wan C (2015), Huttlin EL (2017), Boldt K (2016)	3
ERBIN	5	GRIN2B	30	pull down	Jaulin-Bastard F (2001)	1
ERBIN	5	ACTN2	2	unspecified method	Boisguerin P (2004)	1
GRIN1	13	GRIN2B	30	affinity chromatography technology	Al-Hallaq RA (2002)	1
GRIN1	13	SPTAN1	9	biochemical, pull down	Wechsler A (1998), Wechsler A (1998)	2
ARHGAP32	11	GRIN2B	30	affinity chromatography technology, pull down, two hybrid	Nakazawa T (2003), Nakazawa T (2003), Nakazawa T (2003)	3
ACTN2	2	GRIN2B	30	two hybrid, biochemical	Wyszynski M (1997), Wyszynski M (1997)	2
PRKCA	7	GRIN2B	30	enzymatic study	Wechsler A (1998)	1
TP53	0	GRIN2B	30	genetic interference	Xie L (2013)	1
EXOC7	3	GRIN2B	30	pull down	Sans N (2003)	1
DLG4	11	PRKCA	7	affinity chromatography technology	Lim IA (2002)	1
GRIN2B	30	DLG1	2	affinity chromatography technology, two hybrid	Inanobe A (2002), Niethammer M (1996)	2
KDM5B	27	GRIN2B	30	affinity chromatography technology	Zhou W (2009)	1
PRKN	1	TP53	0	pull down, enzymatic study	Jung YY (2017), Jung YY (2017)	2
GRIN2B	30	DLG2	4	affinity chromatography technology, two hybrid	Inanobe A (2002), Irie M (1997)	2
DLG3	1	DLG4	11	two hybrid, pull down	Masuko N (1999), Masuko N (1999)	2
DLG1	2	LIN7A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Hauri S (2013)	3
PRKCA	7	GRIN1	13	enzymatic study	Wechsler A (1998)	1
CAPN1	3	ACTN2	2	two hybrid	Jiang LQ (2002)	1
DLG3	1	CAMK2A	6	affinity chromatography technology	Ewing RM (2007)	1
DLG4	11	LIN7A	1	pull down	Jo K (1999)	1
LIN7B	0	DLG4	11	affinity chromatography technology	Jo K (1999)	1
EXOC7	3	DLG3	1	pull down	Sans N (2003)	1
DLG3	1	DLG1	2	affinity chromatography technology	Hein MY (2015)	1
PRKN	1	DLG4	11	affinity chromatography technology	Fallon L (2002)	1
EXOC4	2	DLG4	11	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Sans N (2003), Riefler GM (2003), Riefler GM (2003), Riefler GM (2003)	4
EXOC7	3	EXOC4	2	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sans N (2003), Inoue M (2003), Havugimana PC (2012), Bodemann BO (2011), Wan C (2015), Boldt K (2016)	6
CAPN1	3	SPTAN1	9	enzymatic study	Stabach PR (1997)	1
PRKN	1	DLG1	2	imaging technique	Chen TC (2014)	1
DLG2	4	DLG4	11	affinity chromatography technology	Hsueh YP (1997)	1
TP53	0	CAPN1	3	affinity chromatography technology	Fogeron ML (2013)	1
GRIN2B	30	LIN7A	1	pull down	Jo K (1999)	1
DLG3	1	GRIN2B	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Sans N (2003), Sans N (2003), Inanobe A (2002), Irie M (1997), Lim IA (2002), Lim IA (2002)	6
CAMK2A	6	GRIN2B	30	pull down	Bayer KU (2001)	1
LIN7B	0	GRIN2B	30	affinity chromatography technology, pull down	Jo K (1999), Jo K (1999)	2
FYN	1	DLG4	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tezuka T (1999), Hou XY (2002), Hou XY (2002)	3
CAMK2G	4	GRIN2B	30	enzymatic study	Wechsler A (1998)	1
GRIN2B	30	DLG4	11	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, pull down, two hybrid, far western blotting, pull down	Sans N (2003), Inanobe A (2002), Irie M (1997), Niethammer M (1998), Lim IA (2002), Kornau HC (1995), Kornau HC (1995), Niethammer M (1996), Niethammer M (1996), Imamura F (2002)	10
EXOC3	2	DLG3	1	affinity chromatography technology, affinity chromatography technology	Sans N (2003), Sans N (2003)	2