PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CAMK2G	4	GRIN1	13	enzymatic study	Wechsler A (1998)	1
GRIN2B	30	FYN	1	pull down, enzymatic study	Takagi N (1999), Wechsler A (1998)	2
GRIN2B	30	SPTAN1	9	biochemical, pull down	Wechsler A (1998), Wechsler A (1998)	2
FYN	1	GRIN1	13	enzymatic study	Wechsler A (1998)	1
GRIN3B	2	GRIN1	13	affinity chromatography technology	Matsuda K (2002)	1
GRIN1	13	GRIN2B	30	affinity chromatography technology	Al-Hallaq RA (2002)	1
GRIN1	13	SPTAN1	9	biochemical, pull down	Wechsler A (1998), Wechsler A (1998)	2
PRKCA	7	GRIN2B	30	enzymatic study	Wechsler A (1998)	1
CANX	4	SPTAN1	9	biochemical	Wan C (2015)	1
GRIN1	13	GRIN3A	1	affinity chromatography technology	Al-Hallaq RA (2002)	1
LNX1	7	GRIN1	13	two hybrid, enzymatic study	Guo Z (2012), Guo Z (2012)	2
ND2	0	GRIN1	13	affinity chromatography technology	Gingrich JR (2004)	1
PRKCA	7	GRIN1	13	enzymatic study	Wechsler A (1998)	1
LNX1	7	PRKCA	7	affinity chromatography technology	Wolting CD (2011)	1
GRIN2A	13	SPTAN1	9	biochemical, pull down	Wechsler A (1998), Wechsler A (1998)	2
CACNG2	0	GRIN1	13	biochemical	Chen L (2001)	1
GRIN1	13	CANX	4	affinity chromatography technology	Papadakis M (2004)	1
GRIN3B	2	GRIN2A	13	affinity chromatography technology	Matsuda K (2002)	1
GRIN1	13	GRIN2A	13	affinity chromatography technology, affinity chromatography technology	Al-Hallaq RA (2002), Papadakis M (2004)	2
CAMK2G	4	GRIN2B	30	enzymatic study	Wechsler A (1998)	1
FYN	1	GRIN2A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Ma J (2003), Tezuka T (1999), Hou XY (2002), Hou XY (2002), Takagi N (1999), Takagi N (1999)	6