PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MKX	2	SIN3A	13	affinity chromatography technology	Anderson DM (2009)	1
MKX	2	GTF2A1	1	affinity chromatography technology	Anderson DM (2009)	1
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
GTF2A1	1	TBP	0	pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	DeJong J (1995), Langelier MF (2001), Ozer J (1998), Solow S (2001), Sun X (1994), Jeronimo C (2007), Maldonado E (1990), Mitsiou DJ (2003), Mitsiou DJ (2003), Huttlin EL (2015), Huttlin EL (2017), Gupta K (2017)	12
MKX	2	HDAC1	4	affinity chromatography technology	Anderson DM (2009)	1
HDAC1	4	TBL1XR1	23	affinity chromatography technology	Joshi P (2013)	1
SIN3A	13	HSP90AA1	7	affinity chromatography technology	Farhana L (2007)	1
HDAC1	4	TBP	0	affinity chromatography technology	Wu Y (2001)	1
SIN3A	13	TBL1X	1	affinity chromatography technology	Farhana L (2007)	1
ELAVL1	0	MKX	2	affinity chromatography technology	Abdelmohsen K (2009)	1
HSP90AA1	7	MKX	2	affinity chromatography technology	Taipale M (2012)	1
MKX	2	TBL1X	1	affinity chromatography technology	Huttlin EL (2017)	1
GTF2B	1	TBP	0	biochemical, pull down, x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	Scully R (1997), Scully R (1997), Bushnell DA (2004), Friedman MJ (2007), Tsai FT (2000), Bagby S (1995), Lin Y (1997)	7
MKX	2	TBP	0	affinity chromatography technology	Anderson DM (2009)	1
MKX	2	GTF2B	1	affinity chromatography technology	Anderson DM (2009)	1
ELAVL1	0	TBL1XR1	23	affinity chromatography technology	Abdelmohsen K (2009)	1
SIN3A	13	TBP	0	affinity chromatography technology	Nakamura T (2002)	1
MKX	2	TBL1XR1	23	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	TBL1X	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TBL1X	1	TBL1XR1	23	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Perissi V (2008), Choi HK (2008), Bantscheff M (2011), Lan X (2016)	4
ELAVL1	0	TBP	0	affinity chromatography technology	Abdelmohsen K (2009)	1