PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
APEX2	2	CUL9	5	affinity chromatography technology	Huttlin EL (2017)	1
APEX2	2	DDB2	1	affinity chromatography technology	Huttlin EL (2017)	1
NEDD4L	3	EFEMP2	0	enzymatic study	Persaud A (2009)	1
TRIM37	7	TRAF2	1	pull down	Zapata JM (2001)	1
TRIM37	7	APEX2	2	two hybrid	Rual JF (2005)	1
APEX2	2	CUL7	4	affinity chromatography technology	Huttlin EL (2017)	1
CUL7	4	APP	1	affinity chromatography technology	Hanson D (2014)	1
APEX2	2	SIRT1	3	affinity chromatography technology	Huttlin EL (2017)	1
APP	1	APBA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down	Araki Y (2003), Araki Y (2003), Biederer T (2002), Biederer T (2002), Tomita S (1999), Tomita S (1999)	6
APEX2	2	PCNA	0	affinity chromatography technology, pull down	Tsuchimoto D (2001), Tsuchimoto D (2001)	2
TRAF2	1	MAP3K1	4	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Baud V (1999), Baud V (1999), Wu Y (2006), Charlaftis N (2014), Chen TC (2014)	5
APEX2	2	CTU2	0	affinity chromatography technology	Huttlin EL (2017)	1
NINL	1	APEX2	2	two hybrid	Rual JF (2005)	1
CALCOCO2	0	APEX2	2	two hybrid	Rual JF (2005)	1
CCDC85B	0	APEX2	2	two hybrid	Rual JF (2005)	1
APEX2	2	APP	1	pull down	Olah J (2011)	1
TRAF2	1	APEX2	2	two hybrid	Rual JF (2005)	1
APEX2	2	HOOK2	0	two hybrid	Rual JF (2005)	1
CUL7	4	PCNA	0	affinity chromatography technology	Hanson D (2014)	1
APEX2	2	EFEMP2	0	two hybrid	Rual JF (2005)	1
RETN	1	APEX2	2	affinity chromatography technology	Huttlin EL (2017)	1
APEX2	2	APBA2	1	affinity chromatography technology	Huttlin EL (2017)	1
APEX2	2	WDR54	0	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K1	4	APEX2	2	enzymatic study	Charlaftis N (2014)	1
CUL7	4	CUL9	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dowell JD (2007), Skaar JR (2007), Skaar JR (2007), Skaar JR (2007), Skaar JR (2005), Skaar JR (2005)	6
APEX2	2	PDE12	2	biochemical	Havugimana PC (2012)	1
TRAF2	1	CALCOCO2	0	two hybrid	Rual JF (2005)	1
NEDD4L	3	APEX2	2	pull down	Persaud A (2009)	1