PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BLOC1S6	0	SNAPIN	1	biochemical, affinity chromatography technology	Starcevic M (2004), Starcevic M (2004)	2
SCLT1	1	WASHC3	2	affinity chromatography technology	Gupta GD (2015)	1
HDAC2	1	ESR1	0	affinity chromatography technology, affinity chromatography technology	Itoh Y (2007), Tarallo R (2011)	2
BLOC1S2	0	BLOC1S1	0	affinity chromatography technology, two hybrid	Starcevic M (2004), Starcevic M (2004)	2
WASHC3	2	IKBIP	2	affinity chromatography technology	Huttlin EL (2017)	1
SCLT1	1	SNAPIN	1	bioid	Gupta GD (2015)	1
BCAS4	0	SNAPIN	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MTA1	3	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Mazumdar A (2001), Mazumdar A (2001), Mazumdar A (2001), Li DQ (2010), Yan C (2003), Balasenthil S (2007), Ohshiro K (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015)	16
IKBIP	2	APP	1	pull down	Olah J (2011)	1
BLOC1S6	0	BLOC1S1	0	biochemical, two hybrid, two hybrid, affinity chromatography technology	Starcevic M (2004), Starcevic M (2004), Starcevic M (2004), Starcevic M (2004)	4
WASHC3	2	DTNBP1	1	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
BLOC1S1	0	HDAC2	1	affinity chromatography technology	Mishra SK (2003)	1
BCAS4	0	BLOC1S6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IKBIP	2	SNAPIN	1	affinity chromatography technology	Huttlin EL (2017)	1
SCLT1	1	BLOC1S1	0	bioid	Gupta GD (2015)	1
PELP1	3	BLOC1S1	0	two hybrid	Mishra SK (2003)	1
ESR1	0	CLTC	12	affinity chromatography technology	Tarallo R (2011)	1
TEX35	0	BLOC1S2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BORCS6	0	SNAPIN	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DTNBP1	1	BORCS6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DTNBP1	1	BLOC1S3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Starcevic M (2004), Huttlin EL (2015), Huttlin EL (2017)	3
SNAPIN	1	BLOC1S1	0	two hybrid, two hybrid	Starcevic M (2004), Starcevic M (2004)	2
WASHC3	2	BLOC1S1	0	affinity chromatography technology	Huttlin EL (2017)	1
DTNBP1	1	BCAS4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IKBIP	2	BLOC1S1	0	affinity chromatography technology	Huttlin EL (2017)	1
BLOC1S1	0	CLTC	12	biochemical	Wan C (2015)	1
PTEN	24	BLOC1S1	0	genetic interference	Vizeacoumar FJ (2013)	1
TNFRSF8	2	BLOC1S1	0	affinity chromatography technology	Huttlin EL (2017)	1
BCAS4	0	BLOC1S3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BORCS6	0	BLOC1S2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IKBIP	2	BLOC1S2	0	affinity chromatography technology	Huttlin EL (2017)	1
MTA1	3	BLOC1S1	0	two hybrid, pull down, affinity chromatography technology, pull down, two hybrid	Mishra SK (2003), Mishra SK (2003), Mishra SK (2003), Mishra SK (2003), Mishra SK (2003)	5
BLOC1S2	0	SNAPIN	1	affinity chromatography technology, two hybrid, two hybrid, biochemical	Starcevic M (2004), Starcevic M (2004), Starcevic M (2004), Wan C (2015)	4
BCAS4	0	BLOC1S2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MTA1	3	ESR1	0	affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Kumar R (2002), Kumar R (2002), Kumar R (2002), Mazumdar A (2001), Singh RR (2006), Mishra SK (2003)	6
BCAS4	0	BLOC1S1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BLOC1S6	0	DTNBP1	1	biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Starcevic M (2004), Starcevic M (2004), Starcevic M (2004), Huttlin EL (2015), Huttlin EL (2017)	5
WASHC3	2	PTN	0	two hybrid	Stelzl U (2005)	1
PTEN	24	ESR1	0	pull down	Lin HK (2004)	1
ESR1	0	BLOC1S1	0	pull down, affinity chromatography technology	Mishra SK (2003), Mishra SK (2003)	2
TEX35	0	DTNBP1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DTNBP1	1	SNAPIN	1	affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Starcevic M (2004), Starcevic M (2004), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
BLOC1S6	0	BLOC1S2	0	biochemical, affinity chromatography technology, affinity chromatography technology	Starcevic M (2004), Starcevic M (2004), Starcevic M (2004)	3
BLOC1S6	0	WASHC3	2	two hybrid	Rual JF (2005)	1
WASHC3	2	BLOC1S2	0	affinity chromatography technology	Huttlin EL (2017)	1
BLOC1S6	0	BLOC1S3	0	biochemical, affinity chromatography technology, affinity chromatography technology	Starcevic M (2004), Starcevic M (2004), Starcevic M (2004)	3
BLOC1S6	0	APP	1	pull down	Olah J (2011)	1
PELP1	3	ESR1	0	affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Vadlamudi RK (2001), Vadlamudi RK (2001), Barletta F (2004), Barletta F (2004), Tarallo R (2011)	5
BLOC1S2	0	APP	1	pull down	Olah J (2011)	1
MUS81	1	BLOC1S1	0	genetic interference	Vizeacoumar FJ (2013)	1
BLOC1S3	0	SNAPIN	1	affinity chromatography technology	Starcevic M (2004)	1
TEX35	0	SNAPIN	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BLOC1S1	0	APP	1	pull down	Olah J (2011)	1
BORCS6	0	BLOC1S1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PELP1	3	HDAC2	1	affinity chromatography technology, imaging technique	Choi YB (2004), Choi YB (2004)	2
TEX35	0	BLOC1S1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BLOC1S3	0	BLOC1S1	0	affinity chromatography technology	Starcevic M (2004)	1
BORCS6	0	SCLT1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DTNBP1	1	BLOC1S1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Starcevic M (2004), Huttlin EL (2015), Huttlin EL (2017)	3
BLOC1S1	0	PTN	0	two hybrid	Stelzl U (2005)	1
DTNBP1	1	BLOC1S2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Starcevic M (2004), Huttlin EL (2015), Huttlin EL (2017)	3
BLOC1S2	0	BLOC1S3	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Starcevic M (2004), Starcevic M (2004), Starcevic M (2004)	3