PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SH3GL1	3	SH3GL3	1	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Vinayagam A (2011), Ralser M (2005), Ralser M (2005), Ralser M (2005), Huttlin EL (2015), Huttlin EL (2017)	7
ARHGAP8	0	SH3GL1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPL	3	ARHGAP8	0	affinity chromatography technology	Fei T (2017)	1
ISOC1	2	ARHGAP8	0	affinity chromatography technology	Huttlin EL (2017)	1
ARHGAP8	0	PRR5-ARHGAP8	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SH3GL2	1	SH3GL3	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vinayagam A (2011), Ralser M (2005), Ralser M (2005), Ralser M (2005), Huttlin EL (2015), Huttlin EL (2017)	6
LRRC10	1	ARHGAP8	0	affinity chromatography technology	Huttlin EL (2017)	1
ARHGAP8	0	HTR3C	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARHGAP8	0	SH3GL2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SH3GL2	1	SH3GL1	3	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Vinayagam A (2011), Ralser M (2005), Ralser M (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	6
ARHGAP8	0	SH3GL3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2