PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAFF	0	GAPDHS	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NFE2L2	1	MAFG	1	imaging technique, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, affinity chromatography technology	Ramani K (2012), Ramani K (2012), Reinke AW (2013), Reinke AW (2013), Wang J (2011), Wu T (2013), Okita Y (2013)	7
BACH2	6	MAFF	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Huttlin EL (2015), Huttlin EL (2017)	4
GIT1	10	GIT2	2	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology	Kim S (2003), Kim S (2003), Kim S (2003), Huttlin EL (2017)	4
MAFG	1	GTF2A1L	0	two hybrid	Ravasi T (2010)	1
MAFF	0	BATF3	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DDIT3	1	BACH1	3	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAFF	0	CALCOCO1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAFF	0	NFE2L1	4	pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Johnsen O (1996), Reinke AW (2013), Reinke AW (2013), Huttlin EL (2015), Huttlin EL (2017)	5
NR3C1	2	MAFF	0	two hybrid	Ravasi T (2010)	1
MAFF	0	727764	0	two hybrid	Wang J (2011)	1
HDAC5	4	ATF3	0	pull down	Darlyuk-Saadon I (2012)	1
MAFF	0	SUPT16H	4	affinity chromatography technology	Huttlin EL (2015)	1
BATF2	0	DDIT3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
GTF2A1L	0	MAFF	0	two hybrid	Ravasi T (2010)	1
PARP1	3	SUPT16H	4	enzymatic study	Huang JY (2006)	1
PARP1	3	MAFG	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu T (2013), Wu T (2013), Wu T (2013)	3
NR3C1	2	PARP1	3	bioid	Lempiaeinen JK (2017)	1
HOXD12	1	MAFF	0	pull down	Kataoka K (2001)	1
CCDC6	3	NR3C1	2	biochemical	Kristensen AR (2012)	1
BATF3	0	BACH2	6	fluorescent resonance energy transfe, affinity chromatography technology	Reinke AW (2013), Huttlin EL (2017)	2
MAFF	0	NFIL3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
PARP1	3	MAFF	0	affinity chromatography technology	Wu T (2013)	1
MAFG	1	NFIL3	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
DDIT3	1	ATF3	0	affinity chromatography technology, pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Chen BP (1996), Chen BP (1996), Reinke AW (2013), Reinke AW (2013)	4
ATF3	0	FOS	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
HDAC5	4	MAFF	0	two hybrid	Ravasi T (2010)	1
MAFF	0	MIS12	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAFF	0	MAFF	0	pull down, fluorescent resonance energy transfe	Marini MG (2002), Reinke AW (2013)	2
MAFF	0	GIT2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DDIT3	1	BACH2	6	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAFF	0	FOS	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
NFE2L3	6	NFE2L1	4	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAFF	0	RTL6	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAFF	0	NFE2L2	1	pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marini MG (2002), Reinke AW (2013), Okita Y (2013), Huttlin EL (2015), Huttlin EL (2017)	5
MAFF	0	ATF3	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DDIT3	1	MAFF	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
DDIT3	1	RTL6	1	affinity chromatography technology	Behrends C (2010)	1
BATF3	0	ATF3	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DEUP1	0	MAFF	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DDIT3	1	FOS	0	pull down, affinity chromatography technology, fluorescent resonance energy transfe	Ubeda M (1999), Ubeda M (1999), Reinke AW (2013)	3
MAFG	1	BATF3	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
NFE2L3	6	BACH2	6	fluorescent resonance energy transfe	Reinke AW (2013)	1
BATF3	0	BACH1	3	affinity chromatography technology	Huttlin EL (2017)	1
NFE2L3	6	MAFF	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Huttlin EL (2015), Huttlin EL (2017)	4
HOXD12	1	MAFG	1	pull down	Kataoka K (2001)	1
DEUP1	0	MAFG	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAFF	0	BATF2	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
MAFF	0	NEK9	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BACH2	6	MAFG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
NRF1	2	PARP1	3	pull down	Hossain MB (2009)	1
DDIT3	1	BATF3	0	fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Rolland T (2014)	2
BATF3	0	RTL6	1	affinity chromatography technology	Huttlin EL (2017)	1
BATF3	0	GAPDHS	1	affinity chromatography technology	Huttlin EL (2017)	1
BACH1	3	MAFG	1	affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Dohi Y (2008), Reinke AW (2013), Reinke AW (2013), Hein MY (2015), Huttlin EL (2017)	5
MAFF	0	GIT1	10	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAFG	1	MAFF	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DDIT3	1	MAFG	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAFF	0	NRF1	2	pull down	Marini MG (2002)	1
HDAC5	4	PARP1	3	affinity chromatography technology	Greco TM (2011)	1
NFE2L3	6	MAFG	1	fluorescent resonance energy transfe, affinity chromatography technology	Reinke AW (2013), Huttlin EL (2017)	2
NFE2L1	4	BACH2	6	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAFG	1	ATF3	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
HDAC5	4	DDIT3	1	affinity chromatography technology	Ohoka N (2007)	1
PPARG	0	NFE2L3	6	unspecified method	Lee G (2002)	1
NFE2L3	6	NFE2L2	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAFF	0	CCDC6	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BACH1	3	NFE2L2	1	imaging technique, imaging technique	Dhakshinamoorthy S (2005), Dhakshinamoorthy S (2005)	2
MAFF	0	PSAP	3	two hybrid	Stelzl U (2005)	1
DDIT3	1	NFIL3	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAFG	1	NFE2L1	4	pull down, fluorescent resonance energy transfe	Johnsen O (1996), Reinke AW (2013)	2
PPARG	0	MAFF	0	two hybrid	Ravasi T (2010)	1
NR3C1	2	PPARG	0	affinity chromatography technology	Nie M (2005)	1
BACH1	3	MAFF	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	5
MAFF	0	OVOL1	2	two hybrid	Wang J (2011)	1