PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBC	7	EEF1B2	1	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
TOM1L2	0	CUEDC1	4	affinity chromatography technology	Huttlin EL (2017)	1
MYO6	3	TOM1L2	0	affinity chromatography technology, two hybrid	Tumbarello DA (2012), Tumbarello DA (2012)	2
YAP1	0	WBP2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Couzens AL (2013), Hauri S (2013), Schuchardt BJ (2014), Lim SK (2016), Lim SK (2016)	5
WWP2	7	WWP1	3	affinity chromatography technology, affinity chromatography technology	Chaudhary N (2014), Chaudhary N (2014)	2
WBP2	0	MYO6	3	two hybrid	Lim SK (2016)	1
WBP2	0	KRT18	2	pull down	Lim SK (2016)	1
WBP2	0	CUEDC1	4	two hybrid	Lim SK (2016)	1
BAG3	4	WBP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013), Taipale M (2014), Taipale M (2014)	4
MAGI1	3	CTNNB1	30	two hybrid, affinity chromatography technology, pull down	Dobrosotskaya IY (2000), Dobrosotskaya IY (2000), Dobrosotskaya IY (2000)	3
SDHA	2	COPA	6	affinity chromatography technology	Malty RH (2017)	1
UBC	7	TOM1L2	0	pull down, pull down	Nathan JA (2013), Zhang X (2017)	2
UBC	7	COPE	2	affinity chromatography technology	Matsumoto M (2005)	1
UBC	7	SDHA	2	affinity chromatography technology	Matsumoto M (2005)	1
ESR1	0	UIMC1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Yan J (2007), Yan J (2007), Yan J (2007), Yan J (2007)	4
WBP2	0	WWP2	7	unspecified method, affinity chromatography technology, two hybrid, pull down	Pirozzi G (1997), Chaudhary N (2014), Lim SK (2016), Lim SK (2016)	4
UBC	7	TOLLIP	3	pull down, pull down, pull down, biochemical, pull down, pull down, pull down, pull down	Fenner BJ (2009), Nathan JA (2013), Mitra S (2013), Mitra S (2013), Shih SC (2003), Lu K (2014), Lu K (2014), Zhang X (2017)	8
WBP2	0	UIMC1	4	two hybrid	Lim SK (2016)	1
BAG3	4	COPE	2	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
WBP2	0	KRT9	1	pull down	Lim SK (2016)	1
EGFR	5	ITCH	1	affinity chromatography technology	Tong J (2014)	1
EGFR	5	ANKRD13A	1	affinity chromatography technology, affinity chromatography technology	Tanno H (2012), Foerster S (2013)	2
SDHA	2	EEF1B2	1	affinity chromatography technology	Malty RH (2017)	1
COPG1	5	COPE	2	two hybrid, pull down, biochemical, biochemical, biochemical, affinity chromatography technology	Eugster A (2000), Harter C (1998), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	6
COPB2	3	ARCN1	1	affinity chromatography technology, biochemical, biochemical	Wegmann D (2004), Havugimana PC (2012), Wan C (2015)	3
UBE3A	4	UBQLN1	1	two hybrid, affinity chromatography technology	Kleijnen MF (2000), Kleijnen MF (2000)	2
TOLLIP	3	ITCH	1	affinity chromatography technology	Li S (2011)	1
WWP2	7	UBC	7	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Sheng Y (2012), Maspero E (2013), Soond SM (2013), Kristariyanto YA (2015)	4
ARCN1	1	COPE	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TOLLIP	3	TOM1L2	0	two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Katoh Y (2006)	2
UBE3A	4	WBP2	0	two hybrid, pull down	Dhananjayan SC (2006), Dhananjayan SC (2006)	2
TOLLIP	3	ANKRD13A	1	affinity chromatography technology	Li S (2011)	1
UIMC1	4	UBC	7	pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, unspecified method, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Sobhian B (2007), Sobhian B (2007), Wang B (2009), Hu X (2012), Sekiyama N (2012), Cho HJ (2009), Markin CJ (2010), Sekiyama N (2012), Sekiyama N (2012), Sato Y (2009), Sato Y (2009), Nikkilae J (2009), Nikkilae J (2009), Wu J (2009), Guzzo CM (2012), Nathan JA (2013), Anamika A (2014), Kensche T (2012), Yan J (2007), Castaneda CA (2013), Nakasone MA (2013), Thach TT (2015), Zhang X (2017), Li Y (2017), Kristariyanto YA (2017)	25
YAP1	0	NF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Hauri S (2013), Enzo E (2015)	3
WBP2	0	80273	0	pull down	Lim SK (2016)	1
EGFR	5	COPA	6	affinity chromatography technology	Tong J (2014)	1
EGFR	5	KRT9	1	affinity chromatography technology	Yao Z (2017)	1
WBP2	0	ANKRD13A	1	two hybrid	Lim SK (2016)	1
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
ESR1	0	KRT18	2	pull down	Nalvarte I (2010)	1
BAG3	4	TOM1L2	0	affinity chromatography technology	Chen Y (2013)	1
WBP2	0	EPN2	4	two hybrid	Lim SK (2016)	1
NF2	1	WBP2	0	affinity chromatography technology	Zhou L (2015)	1
UBC	7	ARCN1	1	affinity chromatography technology	Matsumoto M (2005)	1
ITCH	1	WWP1	3	affinity chromatography technology	OConnor HF (2015)	1
COPG1	5	ARCN1	1	pull down, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Harter C (1998), Wegmann D (2004), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	6
ESR1	0	MED12	11	affinity chromatography technology, pull down, affinity chromatography technology	Kang YK (2002), Kang YK (2002), Han SJ (2016)	3
EGFR	5	RPS3	0	affinity chromatography technology	Yao Z (2017)	1
UPP1	1	WBP2	0	biochemical	Havugimana PC (2012)	1
CLEC4G	0	WBP2	0	two hybrid	Wang J (2008)	1
YAP1	0	EGFR	5	affinity chromatography technology	Komuro A (2003)	1
MYO6	3	COPB2	3	affinity chromatography technology	Wollscheid HP (2016)	1
UBC	7	ANKRD13A	1	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Tanno H (2012), Zhang X (2017)	3
WWOX	3	WBP2	0	pull down, affinity chromatography technology	Ingham RJ (2005), Abu-Odeh M (2014)	2
COPE	2	COPA	6	two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Stelzl U (2005), Eugster A (2000), Faulstich D (1996), Harter C (1998), Pavel J (1998), Pavel J (1998), Havugimana PC (2012), Wan C (2015)	8
MAGEA4	0	WBP2	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
COPG1	5	COPA	6	pull down, pull down, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Harter C (1998), Harter C (1998), Wegmann D (2004), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	6
NEDD4L	3	CUEDC1	4	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
EGFR	5	HUWE1	22	affinity chromatography technology	Tong J (2014)	1
WBP2	0	HUWE1	22	two hybrid	Lim SK (2016)	1
WBP2	0	EGFR	5	affinity chromatography technology	Lim SK (2016)	1
EGFR	5	EEF1B2	1	affinity chromatography technology	Tong J (2014)	1
UBC	7	MYO6	3	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down	Matsumoto M (2005), Bish RA (2007), He F (2016), He F (2016), Zhang X (2017)	5
UBC	7	NEDD4L	3	x-ray crystallography, enzymatic study, enzymatic study, enzymatic study	Kamadurai HB (2009), Sheng Y (2012), Maspero E (2013), Michel MA (2015)	4
YAP1	0	CTNNB1	30	affinity chromatography technology	Boldt K (2016)	1
WBP2	0	KRT8	3	pull down	Lim SK (2016)	1
HUWE1	22	RPS3	0	affinity chromatography technology	Thompson JW (2014)	1
UBC	7	CUEDC1	4	pull down	Zhang X (2017)	1
COPA	6	ARCN1	1	pull down, biochemical, biochemical, biochemical	Harter C (1998), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
NF2	1	EGFR	5	affinity chromatography technology, fluorescent resonance energy transfe	Guerrero PA (2015), Ivanov AA (2017)	2
ESR1	0	DDX17	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Fujita T (2003), Mooney SM (2010), Tarallo R (2011), Mooney SM (2010), Nalvarte I (2010)	5
WWOX	3	DDX17	2	affinity chromatography technology	Abu-Odeh M (2014)	1
WBP2	0	RHBDD3	1	two hybrid	Lim SK (2016)	1
WBP2	0	SDHA	2	pull down	Lim SK (2016)	1
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
ARCN1	1	COPB1	0	two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical	Eugster A (2000), Faulstich D (1996), Faulstich D (1996), Faulstich D (1996), Lowe M (1996), Harter C (1998), Pavel J (1998), Pavel J (1998), Pavel J (1998), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	12
WBP2	0	HIST1H4A	0	pull down	Lim SK (2016)	1
WBP2	0	COPG1	5	pull down	Lim SK (2016)	1
WBP2	0	COPB2	3	pull down	Lim SK (2016)	1
WBP2	0	POLH	1	two hybrid	Lim SK (2016)	1
WBP2	0	COPB1	0	pull down	Lim SK (2016)	1
WBP2	0	RPS3	0	pull down	Lim SK (2016)	1
CTNNB1	30	ESR1	0	affinity chromatography technology	Kouzmenko AP (2004)	1
WWP2	7	DDX17	2	affinity chromatography technology	Chaudhary N (2014)	1
WBP2	0	RNF168	0	two hybrid	Lim SK (2016)	1
COPB1	0	COPB2	3	two hybrid, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, biochemical	Eugster A (2000), Lowe M (1996), Harter C (1998), Pavel J (1998), Wegmann D (2004), Havugimana PC (2012), Wan C (2015)	7
MED12	11	WBP2	0	affinity chromatography technology	Hein MY (2015)	1
UBE3A	4	UBC	7	enzymatic study, enzymatic study, pull down	Schwarz SE (1998), Ronchi VP (2013), Zhang X (2017)	3
WBP2	0	MAGI1	3	unspecified method	Pirozzi G (1997)	1
TOLLIP	3	NEDD4L	3	affinity chromatography technology	Li S (2011)	1
YAP1	0	ITCH	1	affinity chromatography technology	Levy D (2007)	1
ITCH	1	WBP2	0	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Ingham RJ (2005), OConnor HF (2015), Lim SK (2016), Lim SK (2016), Lim SK (2016), Lim SK (2016), Lim SK (2016)	7
WBP2	0	UBC	7	two hybrid	Lim SK (2016)	1
WBP2	0	WWP1	3	unspecified method, two hybrid	Pirozzi G (1997), Lim SK (2016)	2
NEDD4	2	CUEDC1	4	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
WBP2	0	RPS27A	1	two hybrid	Lim SK (2016)	1
COPB2	3	COPA	6	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical	Eugster A (2000), Harter C (1998), Pavel J (1998), Pavel J (1998), Wegmann D (2004), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	8
COPB2	3	COPE	2	two hybrid, affinity chromatography technology, biochemical	Eugster A (2000), Pavel J (1998), Havugimana PC (2012)	3
COPB2	3	COPG1	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Eugster A (2000), Harter C (1998), Wegmann D (2004), Wegmann D (2004), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	8
ESR1	0	KRT8	3	pull down	Nalvarte I (2010)	1
COPB1	0	COPG1	5	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, biochemical, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Futatsumori M (2000), Lowe M (1996), Futatsumori M (2000), Harter C (1998), Harter C (1998), Pavel J (1998), Wegmann D (2004), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	11
HUWE1	22	WWOX	3	affinity chromatography technology	Thompson JW (2014)	1
EGFR	5	ANKRD13D	4	affinity chromatography technology	Tanno H (2012)	1
ESR1	0	RPS3	0	affinity chromatography technology	Tarallo R (2011)	1
NEDD4	2	ANKRD13D	4	enzymatic study	Persaud A (2009)	1
KRT18	2	KRT8	3	two hybrid, two hybrid	Schnabel J (1998), Wang J (2011)	2
UBC	7	RHBDD3	1	affinity chromatography technology	Matsumoto M (2005)	1
RPS3	0	UBA52	0	biochemical	Havugimana PC (2012)	1
UBC	7	COPB1	0	affinity chromatography technology, pull down	Matsumoto M (2005), Xu P (2017)	2
RPS27A	1	UBA52	0	biochemical	Wan C (2015)	1
WWP1	3	UBC	7	enzymatic study	Kristariyanto YA (2015)	1
HUWE1	22	EEF1B2	1	affinity chromatography technology	Thompson JW (2014)	1
WBP2	0	ANAPC1	1	two hybrid	Lim SK (2016)	1
UBC	7	RPS3	0	pull down	Zhang X (2017)	1
UBC	7	UBQLN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, two hybrid, pull down, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Matsumoto M (2005), Ko HS (2004), Ko HS (2004), Sokratous K (2012), Raasi S (2005), Raasi S (2005), Massey LK (2004), Ko HS (2004), Ko HS (2004), Rolland T (2014), Castaneda CA (2013), Nakayasu ES (2013), Nakayasu ES (2013), Kristariyanto YA (2015), Kristariyanto YA (2015), Kurlawala Z (2017)	16
UBC	7	DDX17	2	affinity chromatography technology	Matsumoto M (2005)	1
WBP2	0	EEF1B2	1	pull down	Lim SK (2016)	1
UBC	7	POLH	1	pull down, two hybrid, pull down, two hybrid, pull down, affinity chromatography technology	Bienko M (2005), Plosky BS (2006), Sekimoto T (2010), Bienko M (2005), Plosky BS (2006), Ahmed-Seghir S (2015)	6
YAP1	0	COPA	6	affinity chromatography technology	Enzo E (2015)	1
UBE3A	4	CTNNB1	30	enzymatic study, affinity chromatography technology	Kuslansky Y (2016), Kuslansky Y (2016)	2
WBP2	0	TDP2	2	two hybrid	Lim SK (2016)	1
MYO6	3	CUEDC1	4	affinity chromatography technology	Huttlin EL (2017)	1
WBP2	0	WWTR1	1	affinity chromatography technology, two hybrid	Lim SK (2016), Lim SK (2016)	2
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
EGFR	5	ESR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hitosugi T (2007), Hitosugi T (2007), Yao Z (2017)	3
WBP2	0	TOM1L2	0	two hybrid	Lim SK (2016)	1
WBP2	0	COPE	2	pull down	Lim SK (2016)	1
WBP2	0	ESR1	0	pull down, affinity chromatography technology	Dhananjayan SC (2006), Dhananjayan SC (2006)	2
UBC	7	ANAPC1	1	pull down	Nathan JA (2013)	1
COPA	6	COPB1	0	two hybrid, affinity chromatography technology, pull down, pull down, biochemical, biochemical, biochemical	Eugster A (2000), Lowe M (1996), Harter C (1998), Harter C (1998), Pavel J (1998), Havugimana PC (2012), Wan C (2015)	7
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
ESR1	0	UBE3A	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li L (2006), Sun J (2012), Dhananjayan SC (2006)	3
UBC	7	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study	Nathan JA (2013), Bish RA (2007), Thompson JW (2014), Kristariyanto YA (2015), Zhang X (2017), Michel MA (2017)	6
NF2	1	80273	0	affinity chromatography technology	Zhou L (2015)	1
WBP2	0	UBQLN1	1	two hybrid	Lim SK (2016)	1
UBC	7	EPN2	4	pull down, pull down	Fenner BJ (2009), Zhang X (2017)	2
ESR1	0	MYO6	3	affinity chromatography technology	Tarallo R (2011)	1
RPS27A	1	RPS3	0	biochemical	Havugimana PC (2012)	1
WBP2	0	NEDD4L	3	affinity chromatography technology, two hybrid	Persaud A (2009), Lim SK (2016)	2
EGFR	5	CTNNB1	30	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hazan RB (1998), Schroeder JA (2002), Takahashi K (1997), Li J (2013)	4
COPB1	0	COPE	2	affinity chromatography technology, pull down, biochemical, biochemical	Lowe M (1996), Harter C (1998), Pavel J (1998), Havugimana PC (2012)	4
WBP2	0	DDX17	2	pull down	Lim SK (2016)	1
HUWE1	22	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Thompson JW (2014), Dominguez-Brauer C (2017), Dominguez-Brauer C (2017), Dominguez-Brauer C (2017)	4
WBP2	0	ANKRD13D	4	two hybrid	Lim SK (2016)	1
NF2	1	RPS3	0	affinity chromatography technology	Zhou L (2015)	1
WBP2	0	COPA	6	pull down	Lim SK (2016)	1
NEDD4	2	WBP2	0	enzymatic study, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study	Persaud A (2009), Persaud A (2009), Persaud A (2009), Ingham RJ (2005), Kathman SG (2015), Qiu Y (2017)	6
ANKRD13D	4	UBC	7	pull down, pull down	Tanno H (2012), Zhang X (2017)	2
WBP2	0	CTNNB1	30	affinity chromatography technology	Lim SK (2016)	1
UBE3A	4	KRT9	1	pull down	Kapoor I (2015)	1
HUWE1	22	COPB2	3	affinity chromatography technology	Thompson JW (2014)	1
NEDD4	2	EGFR	5	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
NEDD4	2	TOM1L2	0	enzymatic study	Persaud A (2009)	1
WWOX	3	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abu-Odeh M (2014), Abu-Odeh M (2014), Abu-Odeh M (2014)	3
WBP2	0	UBA52	0	two hybrid	Lim SK (2016)	1
HUWE1	22	COPG1	5	affinity chromatography technology	Thompson JW (2014)	1
WBP2	0	ARCN1	1	pull down	Lim SK (2016)	1
RNF168	0	UBC	7	pull down, pull down, pull down, pull down, pull down	Panier S (2012), Feng L (2012), Thorslund T (2015), Luijsterburg MS (2017), Luijsterburg MS (2017)	5
WBP2	0	TOLLIP	3	two hybrid	Lim SK (2016)	1