PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ORC5	0	STAB1	9	two hybrid	Wang J (2011)	1
PIK3R2	3	STAB1	9	two hybrid	Wang J (2011)	1
STAB1	9	GGA3	6	pull down	Kzhyshkowska J (2004)	1
CDC5L	2	STAB1	9	affinity chromatography technology	Lleres D (2010)	1
GGA1	0	GGA3	6	imaging technique, pull down, pull down	Ghosh P (2003), Ghosh P (2003), Ghosh P (2003)	3
STAB1	9	GGA2	2	pull down	Kzhyshkowska J (2004)	1
ORC5	0	CDC5L	2	pull down, affinity chromatography technology	Ramachandran N (2004), Lleres D (2010)	2
STAB1	9	GGA1	0	pull down	Kzhyshkowska J (2004)	1
GGA2	2	GGA3	6	pull down, pull down	Ghosh P (2003), Ghosh P (2003)	2
GGA1	0	GGA2	2	imaging technique, pull down, pull down, affinity chromatography technology	Ghosh P (2003), Ghosh P (2003), Ghosh P (2003), Huttlin EL (2017)	4