PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CBX1	0	ZNF292	13	affinity chromatography technology	Hauri S (2016)	1
CBX3	1	ZNF292	13	affinity chromatography technology	Hauri S (2016)	1
SUV39H1	0	ZNF292	13	affinity chromatography technology	Hauri S (2016)	1
CBX1	0	CBX3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Rosnoblet C (2011), Hauri S (2016), Hauri S (2016)	8
CBX3	1	SUV39H1	0	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
P4HB	1	ZNF292	13	affinity chromatography technology	Huttlin EL (2015)	1
SLAMF1	2	ZNF292	13	affinity chromatography technology	Huttlin EL (2015)	1
CBX1	0	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Mateos-Langerak J (2007), Rosnoblet C (2011), Nozawa RS (2010), Hauri S (2016), Hauri S (2016)	10
YEATS4	0	ZNF292	13	affinity chromatography technology	Hein MY (2015)	1
CBX3	1	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Quivy JP (2004), Quivy JP (2004), Quivy JP (2004), Kiyomitsu T (2010), Rosnoblet C (2011), Nozawa RS (2010), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016), Hauri S (2016)	15
SUV39H1	0	CBX1	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Aagaard L (1999), Aagaard L (1999), Aagaard L (1999), Hauri S (2016)	4
NEDD1	1	ZNF292	13	affinity chromatography technology	Hein MY (2015)	1
CBX5	3	SUV39H1	0	two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Fujita N (2003), Rual JF (2005), Nozawa RS (2010), Rolland T (2014), Huttlin EL (2017), Hauri S (2016)	6
CBX5	3	ZNF292	13	affinity chromatography technology	Hauri S (2016)	1
ALB	1	ZNF292	13	affinity chromatography technology	Zhou M (2004)	1