PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SOX2	4	NCOR1	9	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Cox JL (2013)	2
EED	1	BMI1	0	affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014)	4
SPEN	22	RUNX1	0	unspecified method	Salat D (2008)	1
NR3C1	2	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
BMI1	0	BCLAF1	5	affinity chromatography technology	Cao Q (2014)	1
CCNC	0	SPEN	22	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC1	4	RUNX1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Reed-Inderbitzin E (2006), Guo H (2011), Guo H (2011), Guo H (2011), Shia WJ (2012), Leong WY (2016)	6
SRPK2	1	UBE2E2	1	enzymatic study	Varjosalo M (2013)	1
DYNLT1	3	SPEN	22	bioid	Gupta GD (2015)	1
SOX2	4	CUL7	4	affinity chromatography technology	Cox JL (2013)	1
CLK1	1	NCOR1	9	two hybrid	Tai HH (2003)	1
SPEN	22	SCYL2	2	biochemical	Havugimana PC (2012)	1
SOX2	4	NCOR2	12	affinity chromatography technology	Engelen E (2011)	1
CTBP1	2	RBBP8	1	pull down, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Li S (1999), Li S (1999), Schaeper U (1998), Schaeper U (1998), Schaeper U (1998), Schaeper U (1998), Schaeper U (1998), Oswald F (2005), Broderick R (2016)	9
RIDA	0	SPEN	22	two hybrid	Wang J (2011)	1
PPARD	4	SPEN	22	affinity chromatography technology	Shi Y (2002)	1
PPARD	4	NCOR1	9	two hybrid, pull down, pull down, pull down	Shi Y (2002), Krogsdam AM (2002), Krogsdam AM (2002), Lim HJ (2004)	4
NCOR1	9	RUNX1T1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid	Amann JM (2001), Zhang J (2001), Amann JM (2005), Zhang J (2004), Minucci S (2000), Gelmetti V (1998), Gelmetti V (1998), Wei Y (2007)	8
NR3C1	2	SPEN	22	bioid	Lempiaeinen JK (2017)	1
HIF1AN	0	NOTCH2	10	affinity chromatography technology	Rodriguez J (2016)	1
SPEN	22	NOTCH2	10	biochemical	Havugimana PC (2012)	1
HDAC1	4	PPARD	4	affinity chromatography technology, affinity chromatography technology, pull down	Shi Y (2002), Aarenstrup L (2008), Aarenstrup L (2008)	3
SOX2	4	BMI1	0	affinity chromatography technology	Cox JL (2013)	1
MED23	3	CTBP1	2	affinity chromatography technology	Lambert JP (2015)	1
CCNC	0	MED23	3	affinity chromatography technology, bioid, affinity chromatography technology	Huttlin EL (2015), Lambert JP (2015), Huttlin EL (2017)	3
EGFR	5	HDAC1	4	affinity chromatography technology	Yao Z (2017)	1
DYNLT1	3	NR3C1	2	bioid	Gupta GD (2015)	1
CUL7	4	TTN	102	affinity chromatography technology	Hanson D (2014)	1
OBSL1	9	BCLAF1	5	affinity chromatography technology	Hanson D (2014)	1
SPEN	22	PIR	0	biochemical	Havugimana PC (2012)	1
SPEN	22	HDAC1	4	affinity chromatography technology, pull down	Shi Y (2001), Shi Y (2001)	2
ATXN1	2	NCOR1	9	two hybrid	Lim J (2006)	1
SIRT7	1	CUL7	4	affinity chromatography technology	Tsai YC (2012)	1
CLK1	1	BCLAF1	5	two hybrid	Tai HH (2003)	1
EGFR	5	BCLAF1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tong J (2008), Tong J (2014), Yao Z (2017)	3
SPEN	22	UBE2E2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Li J (2006), Li J (2006), Li J (2006), Li J (2006)	4
PIP4K2A	0	SPEN	22	affinity chromatography technology	Huttlin EL (2017)	1
USP37	1	SPEN	22	bioid	Yeh C (2015)	1
ATXN1	2	SPEN	22	two hybrid	Lim J (2006)	1
EGFR	5	TRIML2	0	affinity chromatography technology	Yao Z (2017)	1
SRPK2	1	CLK1	1	enzymatic study	Varjosalo M (2013)	1
BCLAF1	5	SPEN	22	affinity chromatography technology	Hein MY (2015)	1
NCOR2	12	ATXN1	2	two hybrid	Mizutani A (2005)	1
NCOR2	12	RUNX1T1	1	two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, pull down	Takahashi S (2004), Takahashi S (2004), Zhang J (2001), Gelmetti V (1998), Gelmetti V (1998), Gelmetti V (1998)	6
SPEN	22	RUNX1T1	1	unspecified method, affinity chromatography technology, biochemical, two hybrid	Salat D (2008), Salat D (2008), Salat D (2008), Salat D (2008)	4
HDAC1	4	HIF1AN	0	pull down	Mahon PC (2001)	1
SRPK2	1	BCLAF1	5	affinity chromatography technology, enzymatic study	Varjosalo M (2013), Lipp JJ (2015)	2
BMI1	0	SRPK2	1	affinity chromatography technology	Cao Q (2014)	1
SPEN	22	SRA1	0	pull down, affinity chromatography technology	Shi Y (2001), Shi Y (2001)	2
DPPA4	0	SPEN	22	affinity chromatography technology	Oliviero G (2015)	1
SPEN	22	PCBP3	2	biochemical	Havugimana PC (2012)	1
SOX2	4	CTBP1	2	affinity chromatography technology	Engelen E (2011)	1
MED23	3	RBBP8	1	genetic interference	Horlbeck MA (2018)	1
NR3C1	2	NUP54	1	protein complementation assay	Lievens S (2016)	1
NOTCH2	10	RBPJ	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hsieh JJ (1997), Huttlin EL (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017)	5
EGFR	5	CTBP1	2	affinity chromatography technology	Tong J (2014)	1
NCOR2	12	SPEN	22	two hybrid, pull down, affinity chromatography technology, pull down, two hybrid	Shi Y (2001), Shi Y (2001), Shi Y (2001), Shi Y (2001), Albers M (2005)	5
SPEN	22	CTBP1	2	affinity chromatography technology, pull down	Oswald F (2005), Oswald F (2005)	2
SRPK2	1	SPEN	22	enzymatic study	Lipp JJ (2015)	1
SOX2	4	HDAC1	4	affinity chromatography technology	Engelen E (2011)	1
NR3C1	2	NCOR2	12	two hybrid, affinity chromatography technology	Schulz M (2002), Ki SH (2005)	2
HDAC1	4	NCOR2	12	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Fischer DD (2002), Fischer DD (2002), Underhill C (2000), Wang L (2006)	4
SOX2	4	SPEN	22	affinity chromatography technology	Cox JL (2013)	1
OBSL1	9	NUP54	1	affinity chromatography technology	Hanson D (2014)	1
MED23	3	RBPJ	1	bioid, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015)	2
HIF1AN	0	SPEN	22	affinity chromatography technology	Rodriguez J (2016)	1
RUNX1	0	RUNX1T1	1	biochemical, affinity chromatography technology	Minucci S (2000), Shia WJ (2012)	2
NR3C1	2	PRDX3	3	protein complementation assay	Lievens S (2016)	1
UBE2L6	0	RUNX1	0	pull down	Kraemer OH (2008)	1
RBPJ	1	NCOR2	12	two hybrid, two hybrid	Beatus P (2001), Zhou S (2001)	2
SPEN	22	RBBP8	1	pull down, affinity chromatography technology	Oswald F (2005), Oswald F (2005)	2
HDAC1	4	CTBP1	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang CL (2001), Melhuish TA (2000), Sundqvist A (1998), Jin W (2008), Joshi P (2013)	5
RBPJ	1	SPEN	22	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Oswald F (2002), Salat D (2008), Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	5
HDAC1	4	RUNX1T1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Amann JM (2001), Zhang J (2004), Gelmetti V (1998), Liu S (2007), Liu S (2007), Chen TC (2014)	6
CAMKV	2	SPEN	22	affinity chromatography technology	Huttlin EL (2017)	1
NCOR1	9	RUNX1	0	pull down	Minucci S (2000)	1
FERMT3	4	SPEN	22	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	SPEN	22	affinity chromatography technology	Yao Z (2017)	1
TRIML2	0	SPEN	22	affinity chromatography technology	Huttlin EL (2017)	1
BMI1	0	SPEN	22	affinity chromatography technology	Cao Q (2014)	1
CTBP1	2	NCOR2	12	affinity chromatography technology	Mendez LM (2008)	1
CTBP1	2	RUNX1	0	affinity chromatography technology	Nitta E (2005)	1
RUNX1	0	NCOR2	12	x-ray crystallography	Liu Y (2007)	1
UBE2E2	1	RUNX1T1	1	pull down, affinity chromatography technology	Kraemer OH (2008), Kraemer OH (2008)	2
SPEN	22	TTN	102	biochemical	Havugimana PC (2012)	1
CUL7	4	BCLAF1	5	affinity chromatography technology	Hanson D (2014)	1
SPEN	22	BPGM	1	biochemical	Havugimana PC (2012)	1
EED	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), Hein MY (2015)	4
EED	1	SPEN	22	affinity chromatography technology	Cao Q (2014)	1
SRPK2	1	TTN	102	enzymatic study	Varjosalo M (2013)	1
WRAP73	1	SPEN	22	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NCOR1	9	SPEN	22	pull down	Ariyoshi M (2003)	1
EGFR	5	SCYL2	2	affinity chromatography technology	Yao Z (2017)	1
EGFR	5	TTN	102	affinity chromatography technology	Yao Z (2017)	1
SPEN	22	PRDX3	3	biochemical	Havugimana PC (2012)	1
SERTAD1	0	SPEN	22	two hybrid	Wang J (2011)	1
EGFR	5	NR3C1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
CUL7	4	SPEN	22	affinity chromatography technology	Hanson D (2014)	1
NR3C1	2	NCOR1	9	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, bioid	Stevens A (2003), Schulz M (2002), Schulz M (2002), Ki SH (2005), Wang Q (2004), Wang Q (2004), Lempiaeinen JK (2017)	7
CLK1	1	SPEN	22	enzymatic study	Lipp JJ (2015)	1
HDAC1	4	NUP54	1	affinity chromatography technology	Bai XT (2006)	1
SRPK2	1	EED	1	enzymatic study	Lipp JJ (2015)	1
NCOR2	12	NCOR1	9	biochemical, two hybrid	Li J (2000), Korutla L (2005)	2
NR3C1	2	HDAC1	4	affinity chromatography technology, affinity chromatography technology, biochemical, fluorescent resonance energy transfe, pull down	Qiu Y (2006), Jee YK (2005), Kristensen AR (2012), Qiu Y (2011), Qiu Y (2011)	5
SIRT7	1	SPEN	22	affinity chromatography technology	Tsai YC (2012)	1
OBSL1	9	PRDX3	3	affinity chromatography technology	Hanson D (2014)	1
SPEN	22	UBE2L6	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Li J (2006), Li J (2006), Li J (2006), Li J (2006)	4
SOX2	4	RUNX1	0	affinity chromatography technology	Cox JL (2013)	1
SPEN	22	NUP54	1	biochemical	Havugimana PC (2012)	1
OBSL1	9	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litterman N (2011), Litterman N (2011), Hanson D (2011), Hanson D (2011), Nie J (2015)	5
USP37	1	HDAC1	4	bioid	Yeh C (2015)	1
MED23	3	SPEN	22	bioid, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015)	2
CUL7	4	PRDX3	3	affinity chromatography technology	Hanson D (2014)	1
PPARD	4	NCOR2	12	two hybrid, affinity chromatography technology, pull down	Shi Y (2002), Shi Y (2002), Lim HJ (2004)	3
OBSL1	9	SPEN	22	affinity chromatography technology	Hanson D (2014)	1
SOX2	4	SCYL2	2	affinity chromatography technology	Cox JL (2013)	1
RBPJ	1	RUNX1T1	1	affinity chromatography technology	Salat D (2008)	1