PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
YWHAZ	1	APP	1	pull down	Olah J (2011)	1
PSEN2	3	DNAJB1	1	two hybrid	Soler-Lopez M (2011)	1
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
NOS3	7	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
EGFR	5	LONP1	9	affinity chromatography technology, affinity chromatography technology	Tong J (2014), Yao Z (2017)	2
MAST1	9	FBXW4	0	two hybrid	Soler-Lopez M (2011)	1
YWHAZ	1	HNRNPL	3	affinity chromatography technology	Ewing RM (2007)	1
RAB3D	0	CYP2C9	3	two hybrid	Soler-Lopez M (2011)	1
A2M	8	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	CDK5	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
IFIT3	1	IFIT5	0	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Pichlmair A (2011)	2
EGFR	5	EXOC6	1	affinity chromatography technology	Foerster S (2013)	1
ECSIT	3	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
EXOC6	1	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
APOE	1	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
PRDX2	1	APP	1	pull down	Olah J (2011)	1
MAST1	9	RAB3D	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	APOE	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	MGEA5	3	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
EGFR	5	YWHAB	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
A2M	8	FBXW4	0	two hybrid	Soler-Lopez M (2011)	1
EGFR	5	RAB3A	0	protein complementation assay	Deribe YL (2009)	1
RNF32	0	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
SNTB2	4	MAST1	9	pull down	Lumeng C (1999)	1
RNF32	0	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
APP	1	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	APOE	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
APP	1	IFIT3	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
MAST1	9	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	YWHAH	0	affinity chromatography technology	So J (2015)	1
MAST1	9	APP	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
EXOC6	1	APP	1	two hybrid	Soler-Lopez M (2011)	1
IFIT3	1	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	MGEA5	3	two hybrid	Soler-Lopez M (2011)	1
EGFR	5	AP1M2	2	affinity chromatography technology	Foerster S (2013)	1
EGFR	5	YWHAZ	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2009), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
MAST1	9	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	APP	1	affinity chromatography technology, two hybrid	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
ECSIT	3	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	RNLS	0	two hybrid	Soler-Lopez M (2011)	1
AP1M2	2	RAB3D	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	STAMBPL1	2	two hybrid	Soler-Lopez M (2011)	1
APOE	1	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	FBXW4	0	two hybrid	Soler-Lopez M (2011)	1
EGFR	5	MAST1	9	protein complementation assay	Deribe YL (2009)	1
ECSIT	3	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
HNRNPL	3	YWHAE	0	biochemical, affinity chromatography technology	Wan C (2015), Fei T (2017)	2
PSEN2	3	MGEA5	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
APOE	1	NOS3	7	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
APOE	1	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
A2M	8	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
ECSIT	3	DNAJB1	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	CYP2C9	3	two hybrid	Soler-Lopez M (2011)	1
A2M	8	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
AP1M2	2	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	RPP30	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
IFIT5	0	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
APOE	1	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
LOXL4	1	APOE	1	two hybrid	Soler-Lopez M (2011)	1
AP1M2	2	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
A2M	8	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
GCDH	2	NOS3	7	affinity chromatography technology, two hybrid	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
IFIT3	1	APOE	1	two hybrid	Soler-Lopez M (2011)	1
EXOC6	1	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
EXOC6	1	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
CDK5	0	APP	1	pull down	Olah J (2011)	1
PSEN2	3	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	PSEN2	3	two hybrid	Soler-Lopez M (2011)	1
AP1M2	2	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	APP	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	YWHAB	1	affinity chromatography technology	So J (2015)	1
RNF32	0	CYP2C9	3	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
A2M	8	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
RAB3D	0	APP	1	pull down	Olah J (2011)	1
ECSIT	3	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	PSEN2	3	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
ECSIT	3	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
LOXL4	1	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	CYP2C9	3	two hybrid	Soler-Lopez M (2011)	1
A2M	8	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
IFIT3	1	HNRNPL	3	affinity chromatography technology	Pichlmair A (2011)	1
A2M	8	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	FBXL12	1	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
NOS3	7	PSEN2	3	two hybrid	Soler-Lopez M (2011)	1
IFIT5	0	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
A2M	8	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	FBXL12	1	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
MAST1	9	DNAJB1	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	APOE	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
RNF32	0	RPP30	1	two hybrid	Soler-Lopez M (2011)	1
LOXL4	1	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	APP	1	pull down, two hybrid, pull down	Olah J (2011), Soler-Lopez M (2011), Virok DP (2011)	3
MAST1	9	A2M	8	two hybrid	Soler-Lopez M (2011)	1
DNAJB1	1	APP	1	pull down	Olah J (2011)	1
CYP2C8	3	DNAJB1	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
APOE	1	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
EXOC6	1	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
YWHAB	1	YWHAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
APOE	1	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
YWHAB	1	APP	1	pull down	Olah J (2011)	1
APP	1	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
YWHAZ	1	YWHAH	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Hein MY (2015)	4
A2M	8	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
A2M	8	DNAJB1	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	APOE	1	affinity chromatography technology, pull down, two hybrid	Krimbou L (1998), Krimbou L (1998), Soler-Lopez M (2011)	3
MAST1	9	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
PRDX2	1	YWHAZ	1	two hybrid	Wang J (2011)	1
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
A2M	8	STAMBPL1	2	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	YWHAZ	1	affinity chromatography technology	So J (2015)	1
ECSIT	3	APOE	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
A2M	8	MGEA5	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	RAB3D	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	FBXW4	0	two hybrid	Soler-Lopez M (2011)	1
A2M	8	APP	1	two hybrid	Soler-Lopez M (2011)	1
APP	1	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
HNRNPL	3	MAST1	9	affinity chromatography technology	Fei T (2017)	1
RNF32	0	STAMBPL1	2	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
EGFR	5	IFIT5	0	affinity chromatography technology	Tong J (2014)	1
MAST1	9	CDK5	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
A2M	8	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
EGFR	5	CDK5	0	affinity chromatography technology	Tong J (2014)	1
BLMH	0	APP	1	pull down, biochemical	Lefterov IM (2000), Lefterov IM (2000)	2
YWHAE	0	YWHAH	0	two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Bandyopadhyay S (2010), Gloeckner CJ (2007), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	5
CYP2C8	3	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	PRAM1	4	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
MAST1	9	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
FBXW4	0	YWHAH	0	affinity chromatography technology	Lockwood WW (2013)	1
PSEN2	3	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
A2M	8	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
APP	1	PSEN2	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
EXOC6	1	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
A2M	8	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
IFIT3	1	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	MAST1	9	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
IFIT5	0	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	YWHAE	0	affinity chromatography technology	So J (2015)	1
ECSIT	3	STAMBPL1	2	two hybrid	Soler-Lopez M (2011)	1
APP	1	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
PAXIP1	1	MGEA5	3	affinity chromatography technology	Woods NT (2012)	1
EXOSC1	0	APP	1	pull down	Olah J (2011)	1
MAST1	9	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1