Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
SCAP	rs12487736	TT	simvastatin	efficacy	yes	Patients with the TT genotype had less reduction in total cholesterol (p=0.007) and a trend for a lesser reduction in LDL-cholesterol (p=0.088), and did not show a reduction in trigylcerides (p=0.016) compared to patients with the CC+CT genotypes, after 6 months treatment with simvastatin. Please note; variant was described as SCAP 2386A>G, no rsID provided. Alleles have been complemented to the plus chromosomal strand.	Genotype TT is associated with decreased response to simvastatin in people with Hypercholesterolemia as compared to genotypes CC + CT.	16158080	982046088
SCAP	rs12487736	T	fluvastatin	efficacy	no	No association was found with lipid levels, progression or regression with genotypes for this polymorphism. Described as SCAP 2386A/G (I796V) - alleles are complemented here for the plus chromosomal strand.	Allele T is not associated with response to fluvastatin in people with Coronary Artery Disease as compared to allele C.	12436350	982037057
SCAP	rs12487736	C	rosuvastatin	efficacy	yes		Allele C is associated with increased response to rosuvastatin in people with Metabolic Syndrome as compared to allele T.	29318930	1449162025
SCAP	rs12487736	TT	atorvastatin	efficacy	no	No association was seen with % change in total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol, ApoAI or ApoB after 4 weeks treatment. Variant described as SCAP A2386G Ile796Val, and was genotyped using the HpyCH4 IV restriction enzyme. Here, alleles have been complemented and this rsID maps to a position where the T allele abolishes the restriction site.	Genotype TT is not associated with response to atorvastatin in people with Hypercholesterolemia as compared to genotypes CC + CT.	18435918	982046202