PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EAF1	1	AFF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Huttlin EL (2015), Huttlin EL (2017)	3
AQP2	0	ELL2	4	two hybrid	Trimpert C (2017)	1
MED26	2	MLLT3	0	affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Takahashi H (2011)	2
AFF1	1	CCNT1	3	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mueller D (2009), Mueller D (2009), Yokoyama A (2010), Yokoyama A (2010), Benedikt A (2011), Benedikt A (2011), Lu H (2014)	7
ELL2	4	CCNT1	3	affinity chromatography technology	Takahashi H (2011)	1
ELL2	4	NBEAL2	8	affinity chromatography technology	Hein MY (2015)	1
CCNT1	3	CDK9	3	pull down, two hybrid, affinity chromatography technology, two hybrid, two hybrid, two hybrid, pull down, genetic interference, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, biochemical, affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Cabart P (2004), Young TM (2003), Michels AA (2003), Michels AA (2003), Michels AA (2003), Hoque M (2003), Kiernan RE (2001), De Falco G (2000), Fu TJ (1999), Fu TJ (1999), Peng J (1998), Peng J (1998), Peng J (1998), Garber ME (2000), Garber ME (2000), Garber ME (2000), He N (2006), Jeronimo C (2007), Bres V (2009), Gargano B (2007), Yokoyama A (2010), Fryer CJ (2004), Yik JH (2003), Mak AB (2010), Mak AB (2010), Liu M (2012), Shan B (2005), Baumli S (2008), Baumli S (2008), Havugimana PC (2012), Herrmann CH (2001), Herrmann CH (2001), Herrmann CH (2001), Napolitano G (2003), Chen R (2004), Chen R (2004), Chen R (2004), Larochelle S (2012), Yik JH (2005), Napolitano G (1999), Garriga J (1998), Napolitano G (2002), Nguyen VT (2001), Takahashi H (2011), Yang Z (2005), Yang Z (2001), Yang Z (2001), Pinhero R (2004), Byers SA (2005), Wei P (1998), Wei P (1998), Wei P (1998), Wei P (1998), Markert A (2008), Markert A (2008), Markert A (2008), Markert A (2008), Varjosalo M (2013), Varjosalo M (2013), Lu H (2014), Lin PH (2011), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	64
ELL2	4	ICE1	7	affinity chromatography technology	Takahashi H (2011)	1
SIAH1	2	AFF4	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
AFF1	1	CDK9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2010), Yokoyama A (2010), Yokoyama A (2010), Benedikt A (2011), Takahashi H (2011), Varjosalo M (2013), Varjosalo M (2013), Lu H (2014), Lu H (2014), Huttlin EL (2015), Huttlin EL (2017)	11
CTR9	10	AFF4	2	affinity chromatography technology	Hein MY (2015)	1
CASK	18	ELL2	4	two hybrid	Wang J (2011)	1
ELL2	4	EFR3A	3	affinity chromatography technology	Hein MY (2015)	1
CTR9	10	CCNT1	3	affinity chromatography technology	Hein MY (2015)	1
MLLT3	0	CCNT2	4	affinity chromatography technology, affinity chromatography technology	Monroe SC (2011), Takahashi H (2011)	2
MED26	2	CDK9	3	affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Takahashi H (2011)	2
MED26	2	MLLT1	1	affinity chromatography technology	Takahashi H (2011)	1
CTR9	10	ELL2	4	affinity chromatography technology	Hein MY (2015)	1
MLLT1	1	AFF1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mueller D (2009), Park G (2010), Yokoyama A (2010), Yokoyama A (2010), Yokoyama A (2010), Benedikt A (2011), Zeisig DT (2005), Zeisig DT (2005), Zeisig DT (2005), Zeisig DT (2005), Lu H (2014), Ui A (2015)	12
MED26	2	EAF2	1	affinity chromatography technology	Takahashi H (2011)	1
AFF1	1	SIAH1	2	two hybrid, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology	Bursen A (2004), Bursen A (2004), Bursen A (2004), Bursen A (2004), Bursen A (2004)	5
SIAH1	2	ELL2	4	enzymatic study	Liu M (2012)	1
AFF4	2	CCNT1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Estable MC (2002), Yokoyama A (2010), Yokoyama A (2010), Takahashi H (2011), Huttlin EL (2015), Huttlin EL (2017)	6
AFF4	2	ELL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu M (2012), Takahashi H (2011), Takahashi H (2011), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
MLLT1	1	CDK9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mueller D (2009), Park G (2010), Yokoyama A (2010), Yokoyama A (2010), Liu M (2012), He N (2011), He N (2011), Takahashi H (2011), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Ui A (2015), Huttlin EL (2017)	13
PIP4K2A	0	ELL2	4	affinity chromatography technology	Huttlin EL (2017)	1
MED19	1	MED26	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sato S (2004), Sato S (2004), Takahashi H (2011), Tsai KL (2013), Huttlin EL (2015), Huttlin EL (2017)	6
MLLT3	0	CDK9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park G (2010), Monroe SC (2011), Monroe SC (2011), He N (2011), He N (2011), Takahashi H (2011), Takahashi H (2011), Takahashi H (2011), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Li Y (2014), Huttlin EL (2017)	13
ELL2	4	ESYT2	2	affinity chromatography technology	Hein MY (2015)	1
CDK9	3	ELL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu M (2012), He N (2011), Takahashi H (2011), Takahashi H (2011)	4
MLLT1	1	CCNT1	3	affinity chromatography technology	Yokoyama A (2010)	1
OFD1	3	ICE1	7	affinity chromatography technology	Hein MY (2015)	1
MLLT3	0	CCNT1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park G (2010), Monroe SC (2011), Takahashi H (2011)	3
MLLT3	0	AFF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park G (2010), Monroe SC (2011), Benedikt A (2011), Biswas D (2011), Takahashi H (2011)	5
AFF4	2	CCNT2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Huttlin EL (2015), Huttlin EL (2017)	3
ELL2	4	AFG3L2	0	affinity chromatography technology	Hein MY (2015)	1
EAF1	1	MLLT1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
OFD1	3	ELL2	4	affinity chromatography technology	Hein MY (2015)	1
ICE1	7	EAF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Takahashi H (2011), Huttlin EL (2015), Huttlin EL (2017)	4
PIP4K2A	0	AFF1	1	affinity chromatography technology	Huttlin EL (2017)	1
MED19	1	AFF4	2	affinity chromatography technology	Takahashi H (2011)	1
PIP4K2A	0	MLLT3	0	affinity chromatography technology	Huttlin EL (2017)	1
AFF4	2	EAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Huttlin EL (2015), Huttlin EL (2017)	3
CDK9	3	EAF1	1	affinity chromatography technology	Takahashi H (2011)	1
MLLT3	0	AFF4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park G (2010), Monroe SC (2011), Monroe SC (2011), He N (2011), He N (2011), He N (2011), Takahashi H (2011), Takahashi H (2011), Takahashi H (2011), Li Y (2014)	10
PIP4K2A	0	EAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
ELL2	4	SLC4A2	3	affinity chromatography technology	Hein MY (2015)	1
CASK	18	CDK9	3	two hybrid	Wang J (2011)	1
ELL2	4	TIA1	0	affinity chromatography technology	Hein MY (2015)	1
EAF1	1	AFF4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Takahashi H (2011), Huttlin EL (2015), Huttlin EL (2017)	4
MLLT1	1	ELL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	He N (2011), Takahashi H (2011), Hein MY (2015)	3
MLLT3	0	ELL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	He N (2011), Takahashi H (2011), Takahashi H (2011), Hein MY (2015), Li Y (2014)	5
CTR9	10	CDK9	3	affinity chromatography technology	Hein MY (2015)	1
MED26	2	EAF1	1	affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Takahashi H (2011)	2
PIP4K2A	0	CCNT1	3	affinity chromatography technology	Huttlin EL (2017)	1
EAF1	1	PIP4K2A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MED26	2	CCNT2	4	affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Takahashi H (2011)	2
ELL2	4	EAF2	1	affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Yu X (2016)	2
MED26	2	AFF4	2	affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Takahashi H (2011)	2
CDK9	3	CCNT2	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Peng J (1998), Peng J (1998), Peng J (1998), Jeronimo C (2007), Baumli S (2008), Cottone G (2006), Napolitano G (1999), Nguyen VT (2001), Takahashi H (2011), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	14
MED26	2	ELL2	4	affinity chromatography technology	Takahashi H (2011)	1
PIP4K2A	0	MLLT1	1	affinity chromatography technology	Huttlin EL (2017)	1
EAF1	1	EAF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NCSTN	1	ESYT2	2	affinity chromatography technology	Hein MY (2015)	1
AFF1	1	AFF4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2010), Yokoyama A (2010), Yokoyama A (2010), Yokoyama A (2010), Takahashi H (2011)	5
MED26	2	AFF1	1	affinity chromatography technology	Takahashi H (2011)	1
MLLT1	1	AFF4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology	Park G (2010), Yokoyama A (2010), Yokoyama A (2010), Yokoyama A (2010), He N (2011), He N (2011), He N (2011), Takahashi H (2011), Zeisig DT (2005), Wan C (2015), Ui A (2015)	11
ELL2	4	CCNT2	4	affinity chromatography technology	Takahashi H (2011)	1
NCSTN	1	ELL2	4	affinity chromatography technology	Hein MY (2015)	1
EAF1	1	ELL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Simone F (2001), Takahashi H (2011), Takahashi H (2011), Huttlin EL (2015), Huttlin EL (2017)	5
MLLT3	0	MLLT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park G (2010), Monroe SC (2011), He N (2011), Takahashi H (2011)	4
ELL2	4	AFF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Lu H (2014), Hein MY (2015)	3
MED26	2	CCNT1	3	affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Takahashi H (2011)	2
AFF4	2	CDK9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Estable MC (2002), Jeronimo C (2007), Yokoyama A (2010), Yokoyama A (2010), Yokoyama A (2010), Liu M (2012), He N (2011), He N (2011), Takahashi H (2011), Takahashi H (2011), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	14
MLLT3	0	EAF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park G (2010), Takahashi H (2011), Takahashi H (2011), Huttlin EL (2015), Huttlin EL (2017)	5
MED26	2	ICE1	7	affinity chromatography technology	Takahashi H (2011)	1
PIP4K2A	0	AFF4	2	affinity chromatography technology	Huttlin EL (2017)	1
MED19	1	ELL2	4	affinity chromatography technology	Takahashi H (2011)	1