PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HNRNPA1	1	PRMT8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Huttlin EL (2015), Huttlin EL (2017)	3
PRMT1	3	FUS	0	enzymatic study, enzymatic study, two hybrid, affinity chromatography technology	Wada K (2002), Lee J (2002), Stelzl U (2005), Wang T (2014)	4
RAD21	3	EWSR1	2	affinity chromatography technology, affinity chromatography technology	Panigrahi AK (2011), Panigrahi AK (2011)	2
EWSR1	2	MAPK1IP1L	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Wang J (2011), Rolland T (2014)	3
PRMT8	2	PRMT1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Lee J (2005), Weimann M (2013), Weimann M (2013), Weimann M (2013), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	7
EZH2	4	DHX9	3	affinity chromatography technology	Cao Q (2014)	1
EWSR1	2	YY1AP1	0	two hybrid, two hybrid	Rual JF (2005), Wang J (2011)	2
EWSR1	2	PRMT1	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
SF3B4	2	SF1	9	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
VPS72	2	PRMT1	3	two hybrid	Weimann M (2013)	1
PPARGC1A	3	CREBBP	29	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Puigserver P (1999), Puigserver P (1999), Puigserver P (1999), Puigserver P (1999)	4
JUN	0	DHX9	3	affinity chromatography technology	Westermarck J (2002)	1
WBP4	0	SF3B4	2	pull down	Ingham RJ (2005)	1
PPARGC1A	3	EWSR1	2	affinity chromatography technology, affinity chromatography technology	Park JH (2015), Park JH (2015)	2
EWSR1	2	TFG	3	two hybrid, bioid	Rolland T (2014), Elzi DJ (2014)	2
WBP4	0	CPSF7	4	pull down	Ingham RJ (2005)	1
PRMT1	3	DHX9	3	affinity chromatography technology, pull down	Smith WA (2004), Smith WA (2004)	2
ARHGDIA	3	DHX9	3	affinity chromatography technology	Ewing RM (2007)	1
PLSCR1	0	TFG	3	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
EWSR1	2	RPL31	0	two hybrid, affinity chromatography technology	Rual JF (2005), Elzi DJ (2014)	2
EP300	36	PLSCR1	0	two hybrid	Wang J (2011)	1
EWSR1	2	SUZ12	0	two hybrid, affinity chromatography technology	Ravasi T (2010), Cao Q (2014)	2
FUS	0	HNRNPA3	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
HNRNPA1	1	FUS	0	affinity chromatography technology	Roy R (2014)	1
JUN	0	EWSR1	2	pull down, bioid	Fuchs B (2003), Elzi DJ (2014)	2
FUS	0	SF1	9	pull down, affinity chromatography technology	Zhang D (1998), Wang T (2014)	2
EWSR1	2	PLSCR1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
PRMT1	3	HNRNPA1	1	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Lin WJ (1996), Jeronimo C (2007), Robin-Lespinasse Y (2007), Chan JY (2009), Chan JY (2009), Chan JY (2009), Roy R (2014)	7
EWSR1	2	ZNF165	1	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
SUZ12	0	SF1	9	affinity chromatography technology	Cao Q (2014)	1
CPSF7	4	HNRNPA1	1	biochemical	Havugimana PC (2012)	1
ATN1	2	EWSR1	2	two hybrid, bioid	Lim J (2006), Elzi DJ (2014)	2
DHX9	3	EWSR1	2	pull down, affinity chromatography technology, affinity chromatography technology	Toretsky JA (2006), Toretsky JA (2006), Elzi DJ (2014)	3
HNRNPA1	1	MRPS18B	1	affinity chromatography technology	Roy R (2014)	1
HNRNPA1	1	ANXA2	0	affinity chromatography technology	Roy R (2014)	1
EWSR1	2	GORASP2	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
WBP4	0	FUS	0	pull down	Ingham RJ (2005)	1
HNRNPA1	1	EWSR1	2	affinity chromatography technology, affinity chromatography technology	Close P (2012), Roy R (2014)	2
DHX9	3	RPL31	0	biochemical	Havugimana PC (2012)	1
EWSR1	2	MRPS18B	1	two hybrid, biochemical	Rual JF (2005), Havugimana PC (2012)	2
FUS	0	MRPS18B	1	biochemical	Havugimana PC (2012)	1
CDK12	3	EWSR1	2	two hybrid, bioid	Wang J (2011), Elzi DJ (2014)	2
EWSR1	2	HNRNPA3	0	affinity chromatography technology, bioid	Elzi DJ (2014), Elzi DJ (2014)	2
SUZ12	0	SF3B4	2	affinity chromatography technology	Cao Q (2014)	1
TFG	3	MAPK1IP1L	0	two hybrid	Rolland T (2014)	1
EZH2	4	FUS	0	affinity chromatography technology	Cao Q (2014)	1
RAD21	3	HNRNPA3	0	affinity chromatography technology	Panigrahi AK (2011)	1
SMNDC1	1	SF3B4	2	affinity chromatography technology	Ewing RM (2007)	1
EWSR1	2	EIF4H	1	biochemical, bioid	Wan C (2015), Elzi DJ (2014)	2
EWSR1	2	CUEDC2	0	two hybrid, bioid	Rual JF (2005), Elzi DJ (2014)	2
PRMT8	2	EWSR1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BARD1	4	CDK12	3	affinity chromatography technology	Woods NT (2012)	1
EP300	36	EWSR1	2	two hybrid, bioid	Wang J (2011), Elzi DJ (2014)	2
WBP4	0	SF1	9	pull down	Ingham RJ (2005)	1
SMNDC1	1	EWSR1	2	affinity chromatography technology, bioid	Ewing RM (2007), Elzi DJ (2014)	2
EWSR1	2	CREBBP	29	pull down, bioid	Araya N (2003), Elzi DJ (2014)	2
RAD21	3	DHX9	3	affinity chromatography technology	Panigrahi AK (2011)	1
EWSR1	2	SAP30BP	2	biochemical, bioid	Havugimana PC (2012), Elzi DJ (2014)	2
SUZ12	0	PRMT1	3	affinity chromatography technology	Cao Q (2014)	1
PPARGC1A	3	EP300	36	affinity chromatography technology	Cooper MP (2006)	1
EZH2	4	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su IH (2005), Aoto T (2008), Hansen KH (2008), Li G (2010), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Pasini D (2008), Sarma K (2008), Xu B (2011), Xu B (2011), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Lee ST (2011), Havugimana PC (2012), Sahasrabuddhe AA (2014), Wang L (2013), Wu L (2013), Pasini D (2010), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Bhatnagar S (2014), Bhatnagar S (2014), Zhao R (2015), Wienken M (2016), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Mahara S (2016), Hauri S (2016), Hauri S (2016)	40
EWSR1	2	PRDX2	1	affinity chromatography technology, bioid	Elzi DJ (2014), Elzi DJ (2014)	2
FUS	0	SF3B4	2	affinity chromatography technology	Wang T (2014)	1
PRMT8	2	DHX9	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EWSR1	2	CPSF7	4	two hybrid, bioid	Rual JF (2005), Elzi DJ (2014)	2
EWSR1	2	SF3B4	2	two hybrid, bioid	Wang J (2011), Elzi DJ (2014)	2
EWSR1	2	SNRPC	0	pull down, two hybrid	Knoop LL (2000), Knoop LL (2000)	2
EWSR1	2	VPS72	2	two hybrid, bioid	Rual JF (2005), Elzi DJ (2014)	2
SF1	9	EWSR1	2	two hybrid, pull down	Zhang D (1998), Zhang D (1998)	2
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
FUS	0	EIF4H	1	biochemical	Wan C (2015)	1
PRDX2	1	ANXA2	0	biochemical	Wan C (2015)	1
SUZ12	0	CPSF7	4	affinity chromatography technology	Cao Q (2014)	1
RAD21	3	TFG	3	affinity chromatography technology	Panigrahi AK (2011)	1
PPARGC1A	3	SF1	9	affinity chromatography technology	Yazawa T (2010)	1
TDRD3	0	FUS	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Goulet I (2008), Goulet I (2008), Wang J (2011)	3
EP300	36	ARHGDIA	3	enzymatic study	Kuhlmann N (2016)	1
HNRNPA1	1	DHX9	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Close P (2012), Kristensen AR (2012), Roy R (2014), Hein MY (2015)	4
EWSR1	2	CFDP1	1	two hybrid, bioid	Rual JF (2005), Elzi DJ (2014)	2
PLSCR1	0	SF1	9	two hybrid	Rual JF (2005)	1
ATN1	2	PLSCR1	0	two hybrid	Lim J (2006)	1
EP300	36	ANXA2	0	affinity chromatography technology	Jung SY (2005)	1
BARD1	4	EWSR1	2	affinity chromatography technology, pull down, fluorescent resonance energy transfe, two hybrid	Spahn L (2002), Spahn L (2002), Spahn L (2002), Spahn L (2002)	4
ANXA2	0	EWSR1	2	biochemical, affinity chromatography technology	Wan C (2015), Elzi DJ (2014)	2
EP300	36	PRMT1	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Hassa PO (2008), Lai Y (2017), Lai Y (2017)	3
POU4F1	2	EWSR1	2	two hybrid, pull down	Thomas GR (2002), Thomas GR (2002)	2
EWSR1	2	IGF2R	11	affinity chromatography technology, bioid	Elzi DJ (2014), Elzi DJ (2014)	2
ARHGDIA	3	EWSR1	2	affinity chromatography technology, bioid	Ewing RM (2007), Elzi DJ (2014)	2
SUZ12	0	DHX9	3	affinity chromatography technology	Cao Q (2014)	1
EWSR1	2	FUS	0	two hybrid, bioid	Wang J (2011), Elzi DJ (2014)	2
EWSR1	2	EZH2	4	two hybrid, affinity chromatography technology	Ravasi T (2010), Cao Q (2014)	2
EWSR1	2	EWSR1	2	two hybrid, bioid	Wang J (2011), Elzi DJ (2014)	2
SUZ12	0	FUS	0	affinity chromatography technology	Cao Q (2014)	1
ARHGDIA	3	HNRNPA3	0	affinity chromatography technology	Ewing RM (2007)	1
HNRNPA1	1	HNRNPA3	0	affinity chromatography technology, affinity chromatography technology	Roy R (2014), Hein MY (2015)	2
EP300	36	JUN	0	pull down, biochemical, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Campbell KM (2002), Campbell KM (2002), Campbell KM (2002), Subbaramaiah K (2002), Duyndam MC (1999), Wang WM (2011), Deng WG (2004), Deng WG (2004), Cheng SE (2011), Cheng SE (2011), Kim BK (2014), Vries RG (2001), Deng WG (2003), Liu L (2017), Liu L (2017)	15
BARD1	4	SNRPC	0	affinity chromatography technology	Woods NT (2012)	1
EWSR1	2	PTK2B	6	affinity chromatography technology, pull down	Felsch JS (1999), Felsch JS (1999)	2
EZH2	4	CPSF7	4	affinity chromatography technology	Cao Q (2014)	1
FUS	0	SAP30BP	2	biochemical	Havugimana PC (2012)	1
CREBBP	29	JUN	0	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, far western blotting	Sano Y (1998), Sano Y (1998), Merika M (1998), Duyndam MC (1999), Johnson J (2007), Yamaguchi K (2005), Tsai LN (2008), Arias J (1994)	8
WBP4	0	EWSR1	2	pull down, bioid	Ingham RJ (2005), Elzi DJ (2014)	2
TDRD3	0	EWSR1	2	affinity chromatography technology, affinity chromatography technology	Goulet I (2008), Goulet I (2008)	2