PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SMAD1	0	PIAS4	5	two hybrid, affinity chromatography technology, two hybrid	Long J (2003), Long J (2003), Colland F (2004)	3
HDAC4	10	SUV39H1	0	affinity chromatography technology	Zhang CL (2002)	1
CTBP1	2	MECOM	4	affinity chromatography technology, genetic interference, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Chakraborty S (2001), Chakraborty S (2001), Chakraborty S (2001), Izutsu K (2001), Izutsu K (2001), Huttlin EL (2015), Huttlin EL (2017)	7
EHMT2	4	CTBP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ueda J (2006), Kuppuswamy M (2008), Huttlin EL (2015), Huttlin EL (2017)	4
PIAS4	5	SMAD3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Imoto S (2003), Long J (2003), Long J (2003), Long J (2003), Long J (2003), Long J (2003)	6
SMAD3	1	SUV39H1	0	affinity chromatography technology	Wakabayashi Y (2011)	1
HIC1	1	HDAC4	10	affinity chromatography technology	Stankovic-Valentin N (2007)	1
HIC1	1	MBD3	4	affinity chromatography technology	Van Rechem C (2010)	1
EHMT2	4	KAT2B	2	affinity chromatography technology, affinity chromatography technology	Oh ST (2014), Oh ST (2014)	2
UBE2I	0	MECOM	4	enzymatic study	Singh S (2013)	1
CTBP1	2	CREBBP	29	affinity chromatography technology, pull down	Senyuk V (2005), Kim JH (2005)	2
ELAVL1	0	MBD3	4	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD4	9	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moren A (2003), Wotton D (1999), Mori N (2001), Wu JW (2002), Wu JW (2002), Nakao A (1997), Wicks SJ (2000), Wu JW (2001), Chen X (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Razani B (2001), Razani B (2001), Wang B (2008), Moren A (2005), Kurisaki K (2003), Prunier C (2003), Kato Y (2002), Xu J (2000), Wang L (2011), He W (2006), He W (2006), Dupont S (2009), Brown JD (1999), Pardali K (2000), Fu G (2011), Chen W (2007), Gao S (2009), Lin X (2003), Seo SR (2006), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Barrios-Rodiles M (2005), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Ali A (2013), Yamakawa N (2002), Yamakawa N (2002), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Zhou F (2017)	56
CTBP1	2	UBE2I	0	affinity chromatography technology	Kuppuswamy M (2008)	1
SMAD3	1	HDAC4	10	affinity chromatography technology, pull down	Kang JS (2005), Kang JS (2005)	2
PRMT1	3	SIRT1	3	affinity chromatography technology, enzymatic study	Lai Y (2017), Lai Y (2017)	2
CREBBP	29	MECOM	4	affinity chromatography technology, enzymatic study	Chakraborty S (2001), Chakraborty S (2001)	2
UBE2I	0	HDAC1	4	enzymatic study	Citro S (2013)	1
HDAC4	10	MECOM	4	affinity chromatography technology	Chakraborty S (2001)	1
ELAVL1	0	CREBBP	29	affinity chromatography technology	Abdelmohsen K (2009)	1
SIRT1	3	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao X (2005), Dehennaut V (2013), Dehennaut V (2013)	3
ELAVL1	0	CTBP1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
MECOM	4	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Kurokawa M (1998), Kurokawa M (1998), Alliston T (2005), Alliston T (2005)	4
UBE2I	0	CREBBP	29	affinity chromatography technology, pull down, enzymatic study, two hybrid	Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Liu ST (2012)	4
FOXJ2	3	MECOM	4	affinity chromatography technology	Li X (2015)	1
EHMT2	4	MED23	3	affinity chromatography technology	Ding N (2008)	1
MED23	3	CTBP1	2	affinity chromatography technology	Lambert JP (2015)	1
MECOM	4	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology	Vinatzer U (2001), Vinatzer U (2001), Chakraborty S (2001)	3
SMAD4	9	MECOM	4	pull down	Alliston T (2005)	1
SPDEF	2	MECOM	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	MECOM	4	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD4	9	UBE2I	0	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Chang CC (2005), Lin X (2003), Colland F (2004), Wang J (2011), Wang J (2011)	6
SMAD3	1	HDAC1	4	two hybrid, pull down	Liberati NT (2001), Akiyoshi S (1999)	2
EHMT2	4	MECOM	4	affinity chromatography technology	Spensberger D (2008)	1
ELAVL1	0	FOXJ2	3	affinity chromatography technology	Abdelmohsen K (2009)	1
ERMAP	0	MECOM	4	affinity chromatography technology	Huttlin EL (2017)	1
SMAD1	0	SMAD4	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Hanai J (1999), Lopez-Rovira T (2002), Kato Y (2002), Wang L (2011), Li L (2004), Hata A (1998), Barrios-Rodiles M (2005), Wu RY (1997), Wu RY (1997), Colland F (2004), Qiu T (2007), Yan X (2016), Zhou F (2017)	14
SOX2	4	MBD3	4	affinity chromatography technology	Engelen E (2011)	1
MED23	3	KAT2B	2	bioid	Lambert JP (2015)	1
SMAD3	1	KAT2B	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Prokova V (2005), Itoh S (2000), Itoh S (2000), Kahata K (2004), Dai M (2012)	5
HIC1	1	SIRT1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stankovic-Valentin N (2007), Dehennaut V (2012), Dehennaut V (2012), Chen WY (2005), Dehennaut V (2013)	5
SMAD3	1	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid	Brown KA (2008), Wu RY (1997), Wu RY (1997)	3
PIAS4	5	HIC1	1	imaging technique	Sun L (2013)	1
CTBP1	2	KAT2B	2	enzymatic study, affinity chromatography technology, pull down	Fuks F (1998), Senyuk V (2005), Kim JH (2005)	3
L3MBTL1	1	MECOM	4	affinity chromatography technology	Huttlin EL (2017)	1
MECOM	4	MBD3	4	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Spensberger D (2008), Spensberger D (2008), Spensberger D (2008), Spensberger D (2008)	4
PIAS4	5	MECOM	4	affinity chromatography technology, affinity chromatography technology	Singh S (2013), Singh S (2013)	2
ELAVL1	0	SMAD2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
RABGAP1L	4	MECOM	4	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
SMAD2	5	MECOM	4	pull down	Alliston T (2005)	1
SOX2	4	MECOM	4	affinity chromatography technology	Cox JL (2013)	1
SOX2	4	CTBP1	2	affinity chromatography technology	Engelen E (2011)	1
KAT2B	2	MECOM	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chakraborty S (2001), Chakraborty S (2001), Shimahara A (2010), Shimahara A (2010)	4
SMAD1	0	MECOM	4	pull down	Alliston T (2005)	1
HDAC1	4	EHMT2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	3
MECOM	4	NLRP14	3	biochemical	Wan C (2015)	1
SOX2	4	HDAC1	4	affinity chromatography technology	Engelen E (2011)	1
SMAD1	0	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
MED23	3	MECOM	4	bioid	Lambert JP (2015)	1
SMAD2	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Xi Q (2008), Chan EC (2010), He W (2006), Chen W (2007), Colland F (2004), Cui Q (2005)	6
CREBBP	29	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kang JS (2005), Alliston T (2005), Xi Q (2008), Cui Q (2005), Cui Q (2005), Chen W (2007), Nishihara A (1999), Tomita M (2004), Oussaief L (2009), Oussaief L (2009), Cui Q (2005)	11
HDAC4	10	CTBP1	2	pull down	Zhang CL (2001)	1
SUV39H1	0	MECOM	4	affinity chromatography technology, pull down, affinity chromatography technology	Cattaneo F (2008), Cattaneo F (2008), Spensberger D (2008)	3
SOX2	4	EHMT2	4	affinity chromatography technology	Cox JL (2013)	1
ELAVL1	0	MED23	3	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2I	0	HDAC4	10	enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Knipscheer P (2008), Zhao X (2005), Zhao X (2005), Dehennaut V (2013), Tatham MH (2001), Knipscheer P (2007)	6
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
MED23	3	CREBBP	29	bioid, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015)	2
HDAC1	4	CTBP1	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang CL (2001), Melhuish TA (2000), Sundqvist A (1998), Jin W (2008), Joshi P (2013)	5
SMAD2	5	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wotton D (1999), Wotton D (1999), Takeda M (2004), Lo RS (2001)	4
HIC1	1	MECOM	4	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Pradhan AK (2014), Pradhan AK (2014), Pradhan AK (2014)	3
PIK3R3	0	MECOM	4	two hybrid	Grossmann A (2015)	1
HDAC1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mayanil CS (2006), Chuang HC (2006), Chuang HC (2006)	3
SMAD4	9	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
PIAS4	5	UBE2I	0	two hybrid, pull down, pull down, pull down	Wang J (2011), Yamamoto H (2003), Yin Y (2012), Ryu H (2010)	4
MBD3	4	HDAC1	4	affinity chromatography technology, biochemical, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sakai H (2002), Zhang Y (1999), Zhang Y (1999), Saito M (2002), Noh EJ (2009), Noh EJ (2009), Le Guezennec X (2006), Humphrey GW (2001), Sun JM (2007), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	16
SMAD4	9	CREBBP	29	affinity chromatography technology	Yang Y (2015)	1
ELAVL1	0	SIRT1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	HDAC4	10	affinity chromatography technology	Abdelmohsen K (2009)	1
PIAS4	5	SMAD2	5	affinity chromatography technology, two hybrid, affinity chromatography technology	Imoto S (2003), Long J (2003), Long J (2003)	3
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
SUV39H1	0	EHMT2	4	affinity chromatography technology	Huttlin EL (2017)	1
CREBBP	29	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Pearson KL (1999), Sun Y (2001)	2
KAT2B	2	SMAD2	5	pull down, affinity chromatography technology, affinity chromatography technology	Itoh S (2000), Kahata K (2004), Dai M (2012)	3
MECOM	4	PRMT1	3	two hybrid	Weimann M (2013)	1
SUV39H1	0	HDAC1	4	affinity chromatography technology, pull down	Vaute O (2002), Vaute O (2002)	2
ELAVL1	0	PIAS4	5	affinity chromatography technology	Abdelmohsen K (2009)	1
SIRT1	3	KAT2B	2	enzymatic study, affinity chromatography technology, affinity chromatography technology	Pediconi N (2009), Pediconi N (2009), Pediconi N (2009)	3
HIC1	1	CTBP1	2	two hybrid, affinity chromatography technology	Van Rechem C (2009), Stankovic-Valentin N (2006)	2
CREBBP	29	KAT2B	2	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Tini M (2002), Cho H (1998), Cho H (1998), Cho H (1998), Korzus E (1998), Korzus E (1998), Korzus E (1998), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996)	10
L3MBTL1	1	EHMT2	4	affinity chromatography technology	Huttlin EL (2017)	1
PIAS4	5	HDAC1	4	pull down	Gross M (2004)	1
PIAS4	5	SMAD4	9	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Imoto S (2003), Long J (2003), Long J (2003), Long J (2003), Lee PS (2003)	5
UBE2I	0	HIC1	1	enzymatic study, affinity chromatography technology	Stankovic-Valentin N (2007), Dehennaut V (2013)	2
SIRT1	3	MECOM	4	affinity chromatography technology, affinity chromatography technology	Pradhan AK (2011), Pradhan AK (2011)	2
SMAD2	5	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe	Brown KA (2008), Wu RY (1997), Wu RY (1997), Ivanov AA (2017)	4
SIRT1	3	UBE2I	0	enzymatic study	Hsieh YL (2013)	1
SIRT1	3	SUV39H1	0	affinity chromatography technology, affinity chromatography technology	Li Z (2009), Vaquero A (2007)	2