PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	PARK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fan J (2008), Fan J (2008), Kim SJ (2012)	3
DAXX	5	TP53	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, unspecified method	Tang J (2006), Kim EJ (2003), Kim EJ (2003), Kim EJ (2003), Ohiro Y (2003), Ohiro Y (2003), Ohiro Y (2003), Ohiro Y (2003), Wethkamp N (2011), Zhao LY (2004), Zhao LY (2004), Zhao LY (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Zhao LY (2004), Zhao LY (2004), Zhang H (2013), Zhang H (2013), Chen TC (2014), Li Z (2017)	23
HIPK1	1	DDX54	1	affinity chromatography technology	Varjosalo M (2013)	1
HIPK1	1	NEB	21	affinity chromatography technology	Varjosalo M (2013)	1
HIPK1	1	RASSF5	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Lee D (2012), Lee D (2012), Lee D (2012)	3
SIAH1	2	UBE2I	0	two hybrid, two hybrid	Depaux A (2007), Hu G (1997)	2
HIPK1	1	A2M	8	affinity chromatography technology	Varjosalo M (2013)	1
FOXP3	1	HIPK1	1	affinity chromatography technology	Li X (2015)	1
HIPK1	1	HAX1	1	affinity chromatography technology	Varjosalo M (2013)	1
HIPK1	1	DAXX	5	affinity chromatography technology	Ecsedy JA (2003)	1
SIAH1	2	HIPK1	1	affinity chromatography technology	Kim SY (2009)	1
UBE2I	0	HIPK1	1	two hybrid	Bandyopadhyay S (2010)	1
GLUL	2	HIPK1	1	two hybrid	Bandyopadhyay S (2010)	1
HIPK1	1	TP53	0	affinity chromatography technology, two hybrid, two hybrid	Kondo S (2003), Kondo S (2003), Kondo S (2003)	3
PARK7	0	UBE2I	0	two hybrid	Junn E (2005)	1
FHL3	0	UBE2I	0	two hybrid	Rolland T (2014)	1
ATP13A2	1	HIPK1	1	two hybrid	Usenovic M (2012)	1
UBE2I	0	DAXX	5	two hybrid, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, two hybrid	Ryu SW (2000), Knipscheer P (2008), Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Chang CC (2011), Lin DY (2006), Lin DY (2006)	8
PARK7	0	DAXX	5	two hybrid, affinity chromatography technology	Junn E (2005), Junn E (2005)	2
PRPF40A	5	HIPK1	1	two hybrid	Colland F (2004)	1
PRPF40A	5	UBE2I	0	two hybrid	Colland F (2004)	1
SKIL	3	HIPK1	1	two hybrid	Colland F (2004)	1
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
PARK7	0	HIPK1	1	two hybrid, affinity chromatography technology, pull down	Sekito A (2006), Sekito A (2006), Sekito A (2006)	3
FHL3	0	HIPK1	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
SKIL	3	GLUL	2	two hybrid	Colland F (2004)	1
GLUL	2	UBE2I	0	two hybrid	Bandyopadhyay S (2010)	1
SKIL	3	UBE2I	0	two hybrid	Colland F (2004)	1