PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKACG	4	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
HSPA4	3	DNAJA1	2	biochemical	Wan C (2015)	1
EPHA8	4	ENDOG	2	affinity chromatography technology	Huttlin EL (2017)	1
ENDOG	2	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology	Kalinowska M (2005), Kalinowska M (2005), Lee JS (2013)	3
BAG4	2	HSPA8	4	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Miki K (2002), Miki K (2002), Taipale M (2014), Taipale M (2014)	4
HSPA4	3	DNAJA4	2	biochemical	Wan C (2015)	1
ENDOG	2	DKC1	1	biochemical	Wan C (2015)	1
CPA4	2	ENDOG	2	affinity chromatography technology	Huttlin EL (2015)	1
PCGF2	3	ENDOG	2	affinity chromatography technology	Huttlin EL (2017)	1
PTCH1	8	ENDOG	2	affinity chromatography technology	Huttlin EL (2015)	1
ITLN2	1	ENDOG	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ENDOG	2	FEN1	1	affinity chromatography technology	Kalinowska M (2005)	1
ENDOG	2	AIFM1	1	affinity chromatography technology	Kalinowska M (2005)	1
EVL	4	ENDOG	2	affinity chromatography technology	Huttlin EL (2017)	1
HSPA8	4	DNAJA4	2	biochemical	Wan C (2015)	1
ITLN1	0	ENDOG	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNAJA1	2	HSPA8	4	pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Meacham GC (1999), Taipale M (2014), Taipale M (2014), Wan C (2015)	4
BAG4	2	HSPA4	3	affinity chromatography technology	Lau PP (2003)	1
DNAJA4	2	DNAJA1	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
ENDOG	2	BIRC2	1	affinity chromatography technology	Seo TW (2014)	1
STUB1	4	HSPA4	3	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Dai Q (2005), Tateishi Y (2004), Tateishi Y (2004), Ko HS (2009), Qian SB (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Wang L (2011), Wang L (2011), Graf C (2010), Kundrat L (2010), Matsumoto K (2011), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Luo W (2010), Soss SE (2011), Zhou P (2003), Kalia LV (2011), Gao Y (2010), Gao Y (2010), Grelle G (2006), Rao SN (2010), Tetzlaff JE (2008), Kim SA (2005), Dai Q (2003), Zhang X (2011), Zhang X (2011), Muller P (2012), Jang KW (2011), Schuelke JP (2010), Jinwal UK (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Mao RF (2013), Lee JS (2013), Lee JS (2013)	42
TPM1	0	ENDOG	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BAG4	2	STUB1	4	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
STUB1	4	HSPA8	4	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, unspecified method, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Tateishi Y (2004), Tateishi Y (2004), Jiang J (2001), Wang L (2011), Wang L (2011), Wang L (2011), Stankiewicz M (2010), Yang M (2011), Yang M (2011), Urushitani M (2004), Grelle G (2006), Kim SA (2005), Arndt V (2005), Alberti S (2004), Meacham GC (2001), Smith MC (2013), Smith MC (2013), Matsumura Y (2013), Spooner RA (2008), Taipale M (2014), Taipale M (2014), Heimdal K (2014), Grelle G (2006), Grelle G (2006), Kamynina E (2007), Zhang H (2015), Zhang H (2015), Zhang H (2015), Li P (2015), Guo Y (2016), Zhang H (2017), Pakdaman Y (2017)	35
HSPA4	3	HSPA8	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical	Hidalgo-de-Quintana J (2008), Havugimana PC (2012), Taipale M (2014), Taipale M (2014), Wan C (2015)	5
STUB1	4	ENDOG	2	affinity chromatography technology, affinity chromatography technology	Lee JS (2013), Lee JS (2013)	2
ITLN1	0	ITLN2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRK6	3	ENDOG	2	affinity chromatography technology	Huttlin EL (2017)	1
PRKACG	4	ENDOG	2	affinity chromatography technology	Huttlin EL (2017)	1
HSPA8	4	ENDOG	2	affinity chromatography technology	Huttlin EL (2017)	1
AURKB	2	ENDOG	2	affinity chromatography technology	Huttlin EL (2015)	1
NFYC	0	ENDOG	2	affinity chromatography technology	Huttlin EL (2017)	1
SSSCA1	0	ENDOG	2	affinity chromatography technology	Huttlin EL (2017)	1
TPM1	0	STUB1	4	biochemical	Kristensen AR (2012)	1
DNAJA4	2	ENDOG	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
BAG4	2	ENDOG	2	affinity chromatography technology	Huttlin EL (2017)	1
DNAJA1	2	ENDOG	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2