PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2I	0	EP300	36	enzymatic study, affinity chromatography technology	Girdwood D (2003), Bian XL (2017)	2
MAPK8	3	ELK1	2	enzymatic study, enzymatic study, two hybrid, enzymatic study	Cano E (1995), Gupta S (1996), Yao K (2007), Cavigelli M (1995)	4
CDK6	0	ELK1	2	enzymatic study	Anders L (2011)	1
CREBBP	29	ELK1	2	far western blotting	Janknecht R (1996)	1
MAPK1	1	ELK1	2	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Eblen ST (2003), Cano E (1995), Cano E (1995), Himpel S (2000), Han S (2010), Zhang X (2011), Basaki Y (2002), Iwata A (2001), Corbit KC (2003), Zhu Z (2005), Bourguignon LY (2005), Ahmed N (2002), Janknecht R (1997), Cavigelli M (1995), Tapinos N (2005), Eliopoulos AG (2006), Ho DT (2003), Kendrick TS (2004)	18
ELAVL1	0	EWSR1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
SRF	1	CREBBP	29	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Matsuzaki K (2003), Matsuzaki K (2003), Ramirez S (1997), Ramirez S (1997)	4
STK16	1	ELK1	2	enzymatic study	Ohta S (2000)	1
KLF4	2	HDAC1	4	pull down	Noti JD (2005)	1
UBE2I	0	APP	1	enzymatic study	Gocke CB (2005)	1
MAPK1	1	CREBBP	29	enzymatic study	Janknecht R (1996)	1
MAPK9	3	ELK1	2	enzymatic study, two hybrid, enzymatic study	Gupta S (1996), Yao K (2007), Cavigelli M (1995)	3
MAPK9	3	MAPK10	0	affinity chromatography technology	Varjosalo M (2013)	1
ELK1	2	EMX1	1	two hybrid	Ravasi T (2010)	1
EP300	36	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Han Y (2008), Mayanil CS (2006), Simone C (2004), Simone C (2004), Simone C (2004), Liu Y (2012), Mizuguchi Y (2012)	7
PLCG2	11	ELK1	2	two hybrid	Grossmann A (2015)	1
MAPK9	3	MAPK8	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
UBE2I	0	HDAC1	4	enzymatic study	Citro S (2013)	1
ELAVL1	0	CREBBP	29	affinity chromatography technology	Abdelmohsen K (2009)	1
ELK1	2	SRF	1	pull down, pull down	Watson DK (1997), Pingoud V (1994)	2
ELAVL1	0	STARD3NL	1	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2I	0	CREBBP	29	affinity chromatography technology, pull down, enzymatic study, two hybrid	Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Liu ST (2012)	4
PADI4	1	HDAC1	4	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Denis H (2009), Denis H (2009), Denis H (2009), Denis H (2009)	4
MAPK8	3	EP300	36	enzymatic study	See RH (2001)	1
HDAC1	4	MAPK8	3	affinity chromatography technology	Morrison BE (2006)	1
MAPK3	4	CREBBP	29	enzymatic study	Tsai LN (2008)	1
ELAVL1	0	ELK1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ELK1	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
SNCA	0	MAPK8	3	affinity chromatography technology	Pan ZZ (2002)	1
ELK1	2	MAD2L2	0	two hybrid, affinity chromatography technology, pull down, enzymatic study	Zhang L (2007), Zhang L (2007), Zhang L (2007), Zhang L (2007)	4
SNCA	0	MAPK3	4	affinity chromatography technology	Pan ZZ (2002)	1
EP300	36	KLF4	2	pull down, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Evans PM (2007), Yu K (2011), Yu K (2011), Zhang R (2010), Allen KL (2011)	5
ELK1	2	KLF4	2	affinity chromatography technology, affinity chromatography technology	Yoshida T (2008), Yoshida T (2008)	2
ELK1	2	FLI1	2	pull down	Watson DK (1997)	1
APP	1	SNCA	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique	Jensen PH (1997), Yoshimoto M (1995), Tsigelny IF (2008), Tsigelny IF (2008), Tsigelny IF (2008), Olah J (2011), Chen TC (2014)	7
ELAVL1	0	CDK6	0	affinity chromatography technology	Abdelmohsen K (2009)	1
FBXO25	1	PADI4	1	enzymatic study	Teixeira FR (2013)	1
EP300	36	EWSR1	2	two hybrid, bioid	Wang J (2011), Elzi DJ (2014)	2
FLI1	2	UBE2I	0	two hybrid	van den Akker E (2005)	1
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
ELK1	2	HOXB13	1	two hybrid	Ravasi T (2010)	1
HDAC1	4	MAPK9	3	affinity chromatography technology	Morrison BE (2006)	1
EWSR1	2	CREBBP	29	pull down, bioid	Araya N (2003), Elzi DJ (2014)	2
UBE2I	0	ELK1	2	enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study	Yang SH (2006), Yang SH (2006), Yang SH (2006), Yang SH (2003), Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013)	7
MAPK8	3	CRK	0	affinity chromatography technology, pull down, imaging technique	Girardin SE (2001), Girardin SE (2001), Chen TC (2014)	3
ELK1	2	HDAC1	4	pull down	Yang SH (2001)	1
PADI4	1	ELK1	2	affinity chromatography technology, affinity chromatography technology	Zhang X (2011), Zhang X (2011)	2
FLI1	2	SRF	1	pull down	Dalgleish P (2000)	1
MAPK8	3	APP	1	pull down, enzymatic study, pull down	Olah J (2011), Scheinfeld MH (2003), Scheinfeld MH (2003)	3
KLF4	2	APP	1	pull down	Olah J (2011)	1
ELK1	2	EP300	36	genetic interference, pull down, affinity chromatography technology	Li QJ (2003), Li QJ (2003), Li QJ (2003)	3
MAPK3	4	ELK1	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique, enzymatic study	Han S (2010), Zhu Z (2005), Tapinos N (2005), Coxon PY (2003), Chen TC (2014), Dixon DA (2006)	6
MAPK10	0	CREBBP	29	two hybrid	Bandyopadhyay S (2010)	1
MAPK10	0	ELK1	2	enzymatic study	Gupta S (1996)	1
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
HDAC1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mayanil CS (2006), Chuang HC (2006), Chuang HC (2006)	3
SNCA	0	MAPK1	1	affinity chromatography technology, pull down	Pan ZZ (2002), Iwata A (2001)	2
ELK1	2	EWSR1	2	pull down	Watson DK (1997)	1
ELK1	2	STARD3NL	1	two hybrid	Wang J (2011)	1
PADI4	1	APP	1	pull down	Olah J (2011)	1
UBE2I	0	SRF	1	enzymatic study	Matsuzaki K (2003)	1
EP300	36	MAPK1	1	affinity chromatography technology, enzymatic study, enzymatic study	Chen YJ (2007), Chen YJ (2007), Sang N (2003)	3
MAPK10	0	APP	1	pull down	Olah J (2011)	1
CRK	0	ELK1	2	two hybrid	Grossmann A (2015)	1
FBXO25	1	ELK1	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Teixeira FR (2013), Teixeira FR (2013), Teixeira FR (2013)	3
HDAC1	4	MAPK10	0	affinity chromatography technology	Morrison BE (2006)	1
ELK1	2	ELK1	2	affinity chromatography technology	Teixeira FR (2013)	1
SNCA	0	ELK1	2	affinity chromatography technology, affinity chromatography technology	Iwata A (2001), Iwata A (2001)	2
CREBBP	29	KLF4	2	pull down, affinity chromatography technology, enzymatic study, imaging technique, imaging technique	Geiman DE (2000), Geiman DE (2000), Evans PM (2007), Kalra IS (2011), Allen KL (2011)	5