PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EDNRA	1	EDN1	0	pull down	Sakamoto A (1993)	1
EDN1	0	COPS6	0	two hybrid	Stelzl U (2005)	1
UBQLN4	2	BAG6	2	two hybrid, affinity chromatography technology	Lim J (2006), Suzuki R (2016)	2
EDN1	0	EDN1	0	x-ray crystallography, pull down	Hoh F (2004), Hoh F (2004)	2
UBQLN4	2	EDN1	0	two hybrid	Lim J (2006)	1
EDN1	0	BAG6	2	two hybrid	Stelzl U (2005)	1