PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CCNE1	1	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Harbour JW (1999), Manenti S (1999), Horton LE (1997), Higashi H (1996), Jiang W (1998), Connell-Crowley L (1997), Gaiddon C (2003), Zarkowska T (1997), Nakanishi M (1999)	9
HDAC1	4	TFDP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
RBL2	5	LIN54	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2009)	5
E2F4	0	RBL1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen CR (2002), Iavarone A (1999), Schmit F (2007), Moberg K (1996), Magae J (1996), Beijersbergen RL (1994), Ginsberg D (1994), Trimarchi JM (1998)	8
RB1	2	LIN54	1	pull down	Korenjak M (2004)	1
LIN9	3	TFDP2	1	affinity chromatography technology	Litovchick L (2007)	1
BRCA1	7	RB1	2	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, pull down, pull down, affinity chromatography technology, genetic interference	Aprelikova ON (1999), Fan S (2001), Fan S (2001), Fan S (2001), Yarden RI (1999), Aprelikova ON (1999), Aprelikova ON (1999), Shen JP (2017)	8
CEBPA	0	CDK2	0	biochemical, affinity chromatography technology, pull down, affinity chromatography technology	Wang H (2001), Wang H (2001), Wang H (2001), Wang GL (2004)	4
CEBPA	0	CDK4	2	biochemical, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Wang H (2001), Wang H (2001), Wang H (2001), Wang H (2002), Wang GL (2004)	5
XPO1	8	LIN9	3	affinity chromatography technology	Kirli K (2015)	1
MOV10	6	E2F4	0	affinity chromatography technology	Castello A (2012)	1
23429	0	TFDP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	4
E2F4	0	KMT2A	58	affinity chromatography technology	Takeda S (2006)	1
FHL2	0	SMAD3	1	pull down, affinity chromatography technology	Ding L (2009), Ding L (2009)	2
CDK2	0	LIN37	0	affinity chromatography technology	So J (2015)	1
BRCA1	7	AR	3	pull down, pull down, two hybrid	Park JJ (2000), Yeh S (2000), Yeh S (2000)	3
E2F4	0	SIN3A	13	affinity chromatography technology	Tyagi S (2007)	1
TFDP1	3	TRIM28	1	affinity chromatography technology	Hauri S (2016)	1
CDK2	0	RBL1	1	enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Leng X (2002), Zhao J (1998), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	8
PML	7	RB1	2	affinity chromatography technology, affinity chromatography technology, pull down	Alcalay M (1998), Alcalay M (1998), Alcalay M (1998)	3
LIN9	3	RB1	2	affinity chromatography technology, pull down, pull down	Gagrica S (2004), Gagrica S (2004), Korenjak M (2004)	3
MOV10	6	HIRA	5	affinity chromatography technology	Castello A (2012)	1
CCNE1	1	AR	3	affinity chromatography technology	Yamamoto A (2000)	1
E2F4	0	PCM1	5	two hybrid	Wang J (2011)	1
TRIM28	1	SIN3A	13	pull down	Nomura T (2004)	1
AR	3	HDAC1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gaughan L (2002), Gaughan L (2002), Gaughan L (2005), Gaughan L (2005), Gobinet J (2005), Peche LY (2015)	6
E2F4	0	ASH2L	2	affinity chromatography technology	Tyagi S (2007)	1
AR	3	SMAD3	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Chipuk JE (2002), Hayes SA (2001), Hayes SA (2001), Hayes SA (2001), Chipuk JE (2002), Hayes SA (2001), Hayes SA (2001), Kang HY (2002), Kang HY (2002), Kang HY (2002), Kang HY (2002), Chipuk JE (2002)	12
HCFC1	4	E2F4	0	affinity chromatography technology, two hybrid	Tyagi S (2007), Tyagi S (2007)	2
E2F4	0	SPIB	3	two hybrid	Giangrande PH (2003)	1
HDAC3	5	GMNN	0	affinity chromatography technology	Kim MY (2006)	1
PML	7	NCOR2	12	pull down, affinity chromatography technology	Khan MM (2001), Hong SH (2001)	2
CDK4	2	RBL1	1	enzymatic study	Anders L (2011)	1
CHMP2A	3	E2F4	0	two hybrid	Wang J (2011)	1
ASF1A	0	E2F4	0	imaging technique	Pchelintsev NA (2013)	1
CEBPA	0	RB1	2	affinity chromatography technology, affinity chromatography technology	Bararia D (2008), Wang GL (2004)	2
LIN54	1	TFDP2	1	affinity chromatography technology	Litovchick L (2007)	1
UBN1	3	HIRA	5	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ray-Gallet D (2011), Tang Y (2012), Tang Y (2012), Tang Y (2012), Tang Y (2012), Tang Y (2012), Lee JS (2016), Lee JS (2016), Lee JS (2016), Pchelintsev NA (2013), Pchelintsev NA (2013)	11
E2F4	0	SMAD3	1	affinity chromatography technology, pull down	Chen CR (2002), Chen CR (2002)	2
ID2	0	RBL1	1	affinity chromatography technology	Lasorella A (2000)	1
CCNE1	1	RBL1	1	affinity chromatography technology	Shanahan F (1999)	1
TRIM28	1	E2F4	0	affinity chromatography technology, affinity chromatography technology	Chen L (2012), Chen L (2012)	2
RB1	2	AR	3	pull down, pull down, two hybrid, affinity chromatography technology	Lu J (1998), Yeh S (1998), Yeh S (1998), Gamble SC (2007)	4
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
HDAC1	4	TRIM28	1	affinity chromatography technology, affinity chromatography technology, biochemical	Allouch A (2011), Chen L (2012), Kristensen AR (2012)	3
XPO1	8	CHMP2A	3	affinity chromatography technology	Kirli K (2015)	1
AR	3	FHL2	0	two hybrid, pull down, affinity chromatography technology	Mueller JM (2000), Mueller JM (2000), Mueller JM (2000)	3
AR	3	ASH2L	2	affinity chromatography technology, affinity chromatography technology	Grasso CS (2012), Grasso CS (2012)	2
CDK2	0	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Shintani S (2000), Nair JS (2009), Takaki T (2004), Shen WH (2004), He W (2003), Peiretti A (2003), Harbour JW (1999), Horton LE (1997), Higashi H (1996), Delston RB (2011), Kim KS (2002), Chen W (2004), Liberal V (2012), Boyer Arnold N (2005), Dynlacht BD (1997), Knudsen ES (1996), Jiang W (1998), De Luca A (1997), Chen Z (2002), Hara E (1997), Connell-Crowley L (1997), Matsuura I (2004), Chen J (1996), Gaiddon C (2003), Seo DW (2006), Zarkowska T (1997), Grimmler M (2007), Nakanishi M (1999), Pevarello P (2005), Iyer NG (2007), Chan HM (2001), Pan W (2001)	32
BRCA1	7	XPO1	8	affinity chromatography technology	Ertych N (2016)	1
LIN9	3	RBL1	1	affinity chromatography technology	Schmit F (2007)	1
RBL2	5	ID2	0	affinity chromatography technology, affinity chromatography technology	Rodriguez JL (2006), Lasorella A (2000)	2
CCNE1	1	CDK4	2	affinity chromatography technology, fluorescent resonance energy transfe	Datta NS (1998), Ivanov AA (2017)	2
HDAC1	4	PML	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Khan MM (2001), Khan MM (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Morey L (2008), Kuo HY (2013), Kim YE (2015)	10
KAT2A	1	CDK2	0	enzymatic study	Mateo F (2009)	1
KMT2A	58	ASH2L	2	affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, biochemical, pull down	Yokoyama A (2004), Yokoyama A (2004), Yokoyama A (2004), Blobel GA (2009), Butler JS (2011), Mak AB (2010), Dharmarajan V (2012), Patel A (2014), Tang Z (2013), Li Y (2016), Alicea-Velazquez NL (2016), Weirich S (2017), Weirich S (2017)	13
CCDC183	3	PCM1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AR	3	RBL1	1	affinity chromatography technology	Su S (2013)	1
1820	0	E2F4	0	affinity chromatography technology	Fukuyo Y (2004)	1
1820	0	PML	7	affinity chromatography technology, enzymatic study	Fukuyo Y (2004), Fukuyo Y (2004)	2
HDAC3	5	RBL1	1	affinity chromatography technology	Lai A (1999)	1
EGFR	5	HDAC1	4	affinity chromatography technology	Yao Z (2017)	1
E2F4	0	ATAD2	6	affinity chromatography technology, pull down	Revenko AS (2010), Revenko AS (2010)	2
PML	7	HDAC3	5	affinity chromatography technology, pull down	Wu WS (2001), Wu WS (2001)	2
LIN9	3	TFDP1	3	affinity chromatography technology	Litovchick L (2007)	1
EGFR	5	TRIM28	1	affinity chromatography technology	Liccardi G (2014)	1
NXF1	0	XPO1	8	affinity chromatography technology	Bachi A (2000)	1
LIN54	1	E2F4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Schmit F (2007)	3
POMC	0	E2F4	0	affinity chromatography technology	Huttlin EL (2017)	1
CDK2	0	ID2	0	enzymatic study, enzymatic study	Deed RW (1997), Hara E (1997)	2
SMAD3	1	HDAC1	4	two hybrid, pull down	Liberati NT (2001), Akiyoshi S (1999)	2
PML	7	RBL2	5	affinity chromatography technology, affinity chromatography technology, imaging technique	Martin N (2012), Martin N (2012), Martin N (2012)	3
LIN54	1	LIN37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Schmit F (2007), Huttlin EL (2015), Huttlin EL (2017)	9
BRCA1	7	FHL2	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Yan J (2003), Yan J (2003), Yan JH (2003), Yan JH (2003), Yan JH (2003), Yan J (2003), Wang J (2011), Hill SJ (2014)	8
TRIM28	1	HCFC1	4	biochemical	Wan C (2015)	1
SMAD3	1	BRCA1	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dubrovska A (2005), Dubrovska A (2005), Dubrovska A (2005), Li H (2009), Li H (2009)	5
KMT2A	58	HCFC1	4	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Yokoyama A (2004), Yokoyama A (2004), Tang Z (2013)	4
RBL2	5	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ferreira R (1998), Bouzahzah B (2000), Bouzahzah B (2000), Iavarone A (1999)	4
E2F4	0	FHL2	0	two hybrid	Schlisio S (2002)	1
UBN1	3	E2F4	0	imaging technique	Pchelintsev NA (2013)	1
PML	7	E2F4	0	affinity chromatography technology, affinity chromatography technology	Martin N (2012), Martin N (2012)	2
PML	7	EGFR	5	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Kuo HY (2013), Kuo HY (2013), Kuo HY (2013), Kuo HY (2013)	4
23429	0	MGA	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	4
RB1	2	TFDP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu CL (1995), Binne UK (2007), Hauri S (2016)	3
RB1	2	HDAC1	4	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Dick FA (2000), Fuks F (2000), Puri PL (2001), Puri PL (2001), Wang S (2002), Luo RX (1998), Luo RX (1998), Lai A (1999), Lai A (1999), Ferreira R (1998), Kimura H (2003), Qiu Z (2008), Fedele M (2006), Brown VD (2002), Khan MM (2001), Dasgupta P (2004), Chang YC (2001), Dahiya A (2000), Zhang HS (2000), Tokitou F (1999), Nguyen DX (2004), Takaki T (2004), Magnaghi-Jaulin L (1998), Magnaghi-Jaulin L (1998), Brehm A (1998), Brehm A (1998), Brehm A (1998), Sun JM (2007), Fan LX (2012), Harbour JW (1999), Brehm A (1999), Joshi P (2013), Chen TT (2000), Chen TT (2000), Chen TT (2000), Chen TT (2000)	36
BRCA1	7	HDAC1	4	pull down	Yarden RI (1999)	1
GMNN	0	E2F4	0	affinity chromatography technology	Huttlin EL (2017)	1
LIN9	3	E2F4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Osterloh L (2007)	4
AR	3	NCOR2	12	two hybrid, pull down, imaging technique, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, bioid	Liao G (2003), Liao G (2003), Liao G (2003), Song LN (2004), Dotzlaw H (2002), Dotzlaw H (2002), Dotzlaw H (2002), Liao G (2003), Dotzlaw H (2003), Cui J (2011), Li Y (2012), Li Y (2012), Moehren U (2007), Lempiaeinen JK (2017)	14
LIN54	1	LIN9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Huttlin EL (2017)	7
LIN37	0	E2F4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Schmit F (2007)	3
HCFC1	4	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Wysocka J (2003), Wysocka J (2003)	2
BRCA1	7	ASH2L	2	two hybrid, affinity chromatography technology	Woods NT (2012), Ertych N (2016)	2
E2F4	0	ID2	0	affinity chromatography technology	Rodriguez JL (2006)	1
CDK2	0	GMNN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
CCDC183	3	CEBPA	0	affinity chromatography technology	Huttlin EL (2017)	1
TFDP3	0	RB1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIRA	5	E2F4	0	imaging technique	Pchelintsev NA (2013)	1
NXF1	0	SIN3A	13	affinity chromatography technology	Castello A (2012)	1
BRCA1	7	RBL1	1	imaging technique, pull down	Fan S (2001), Fan S (2001)	2
23429	0	TFDP2	1	affinity chromatography technology	Huttlin EL (2017)	1
AR	3	HDAC3	5	pull down, affinity chromatography technology	Franco PJ (2003), Zhu P (2006)	2
E2F4	0	XPO1	8	affinity chromatography technology, unspecified method	Ohtani N (2003), Xu D (2012)	2
RBL1	1	TFDP1	3	affinity chromatography technology	Wu CL (1995)	1
CDK4	2	SMAD3	1	enzymatic study, imaging technique	Matsuura I (2004), Chen TC (2014)	2
SMAD3	1	CEBPA	0	pull down	Choy L (2003)	1
CDK4	2	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Nair JS (2009), Takaki T (2004), Deep G (2006), Kehn K (2004), Scholz A (2003), Gladden AB (2003), Mori S (1999), Higashi H (1996), Musgrove EA (1996), Sarmento LM (2005), Kim KS (2002), Li J (2002), Garcia-Morales P (2006), Tsai CH (2009), Miralem T (2003), Toji S (2004), Halder SK (2005), Dynlacht BD (1997), Mandal M (1998), Voit R (1999), Annicotte JS (2006), Connell-Crowley L (1997), Matsuura I (2004), Chen J (1996), Kitagawa M (1996), Anders L (2011), Gaiddon C (2003), Seo DW (2006), Kabuta T (2013), Lee B (2006), Kossatz U (2006), Zarkowska T (1997), Nakanishi M (1999), Iyer NG (2007), Guidoboni M (2005), Barbash O (2009), Wang C (2001), Denicourt C (2008), Pan W (2001)	39
E2F4	0	TFDP2	1	x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zheng N (1999), Huttlin EL (2015), Trimarchi JM (1998), Huttlin EL (2017)	4
BRCA1	7	RBL2	5	imaging technique, pull down	Fan S (2001), Fan S (2001)	2
CDK2	0	TFDP1	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Dynlacht BD (1997), Dynlacht BD (1997), So J (2015)	3
XPO1	8	LIN37	0	affinity chromatography technology	Kirli K (2015)	1
RBL1	1	TFDP2	1	affinity chromatography technology	Wu CL (1995)	1
RBL2	5	RBL1	1	affinity chromatography technology	Litovchick L (2007)	1
BRCA1	7	TRIM28	1	affinity chromatography technology	Ertych N (2016)	1
RBL2	5	TFDP1	3	affinity chromatography technology	Litovchick L (2007)	1
BRCA1	7	MOV10	6	affinity chromatography technology	Ertych N (2016)	1
BRCA1	7	CDK4	2	pull down, enzymatic study, enzymatic study	Wang H (1997), Kehn K (2007), Miralem T (2003)	3
E2F4	0	POLR1D	4	two hybrid	Wang J (2011)	1
SIN3A	13	ID2	0	affinity chromatography technology	Rodriguez JL (2006)	1
GMNN	0	TFDP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
HDAC3	5	TRIM28	1	affinity chromatography technology	Tsuruma R (2008)	1
CEBPA	0	AR	3	pull down	Boruk M (1998)	1
LIN37	0	TFDP2	1	affinity chromatography technology	Litovchick L (2007)	1
TFDP1	3	MGA	9	affinity chromatography technology	Hauri S (2016)	1
AP3S2	0	E2F4	0	two hybrid	Wang J (2011)	1
KAT2A	1	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBN1	3	ASF1A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang Y (2012), Hein MY (2015), Huttlin EL (2017), Pchelintsev NA (2013), Pchelintsev NA (2013)	5
RBL2	5	LIN9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Osterloh L (2007)	5
BRCA1	7	CCNE1	1	affinity chromatography technology	Matsuoka S (2007)	1
CDK4	2	HDAC1	4	genetic interference	Shen JP (2017)	1
HDAC3	5	E2F4	0	affinity chromatography technology, affinity chromatography technology	Li Y (2012), Li Y (2012)	2
RBL2	5	TFDP2	1	affinity chromatography technology	Litovchick L (2007)	1
CDK2	0	HCFC1	4	affinity chromatography technology	Neganova I (2011)	1
HDAC1	4	NCOR2	12	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Fischer DD (2002), Fischer DD (2002), Underhill C (2000), Wang L (2006)	4
XPO1	8	AP3S2	0	affinity chromatography technology	Kirli K (2015)	1
ID2	0	RB1	2	affinity chromatography technology	Lasorella A (2000)	1
LIN37	0	TFDP1	3	affinity chromatography technology	Litovchick L (2007)	1
NXF1	0	LIN9	3	affinity chromatography technology	Castello A (2012)	1
PML	7	HIRA	5	affinity chromatography technology, imaging technique	Delbarre E (2013), Delbarre E (2013)	2
SMAD3	1	SIN3A	13	pull down	Liberati NT (2001)	1
CEBPA	0	HDAC1	4	affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology	Duan H (2005), Matsunaga N (2012), Matsunaga N (2012), Girard N (2013)	4
E2F4	0	AR	3	affinity chromatography technology, affinity chromatography technology	Li Y (2012), Li Y (2012)	2
HDAC3	5	RB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fajas L (2002), Lai A (1999), Lai A (1999), Dahiya A (2000)	4
CDK2	0	PML	7	enzymatic study	Yuan WC (2011)	1
RB1	2	E2F4	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fajas L (2000), Iavarone A (1999), Moberg K (1996), Ezhevsky SA (1997), Ginsberg D (1994), Trimarchi JM (1998)	6
CEBPA	0	E2F4	0	affinity chromatography technology, affinity chromatography technology	Bararia D (2008), Wang GL (2004)	2
EGFR	5	E2F4	0	affinity chromatography technology	Yao Z (2017)	1
E2F4	0	23429	0	two hybrid	Schlisio S (2002)	1
PML	7	SIN3A	13	pull down, affinity chromatography technology	Khan MM (2001), Khan MM (2001)	2
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
CCNE1	1	E2F4	0	affinity chromatography technology	Shanahan F (1999)	1
LIN54	1	TFDP1	3	affinity chromatography technology	Litovchick L (2007)	1
CDK2	0	TRIM28	1	affinity chromatography technology	Neganova I (2011)	1
CCNE1	1	RBL2	5	affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Li Y (1993)	2
AR	3	KMT2A	58	affinity chromatography technology, affinity chromatography technology	Grasso CS (2012), Grasso CS (2012)	2
NXF1	0	E2F4	0	affinity chromatography technology	Castello A (2012)	1
HDAC3	5	XPO1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang WM (2002), Lai IL (2007), Kirli K (2015)	3
NCOR2	12	E2F4	0	affinity chromatography technology, affinity chromatography technology	Li Y (2012), Li Y (2012)	2
KAT2A	1	TRRAP	31	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McMahon SB (2000), Helmlinger D (2006), Meyer KD (2008), Krebs AR (2010), Kim J (2010), Kim J (2010), Liu X (2003)	7
RBL2	5	LIN37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007)	4
NCOR2	12	SIN3A	13	biochemical, pull down	Li J (2000), Huang EY (2000)	2
SMAD3	1	KAT2A	1	affinity chromatography technology	Kahata K (2004)	1
E2F4	0	TRRAP	31	affinity chromatography technology	Lang SE (2001)	1
DNMT3L	2	E2F4	0	pull down, imaging technique, affinity chromatography technology	Pacaud R (2014), Pacaud R (2014), Pacaud R (2014)	3
RB1	2	TFDP2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu CL (1995), Huttlin EL (2015), Huttlin EL (2017)	3
ASH2L	2	HCFC1	4	pull down, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Mak AB (2010), Tang Z (2013)	3
CDK2	0	ID3	0	enzymatic study	Deed RW (1997)	1
23429	0	HDAC1	4	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	ENO1	3	two hybrid, affinity chromatography technology	Woods NT (2012), Ertych N (2016)	2
SMAD3	1	PML	7	affinity chromatography technology	Lin HK (2004)	1
CDK2	0	ENO1	3	affinity chromatography technology	Neganova I (2011)	1
E2F4	0	MGA	9	two hybrid	Giangrande PH (2003)	1
EGFR	5	HCFC1	4	affinity chromatography technology	Tong J (2008)	1
NXF1	0	HIRA	5	affinity chromatography technology	Castello A (2012)	1
CDK2	0	SMAD3	1	enzymatic study, imaging technique	Matsuura I (2004), Chen TC (2014)	2
LIN54	1	RBL1	1	affinity chromatography technology	Schmit F (2007)	1
KMT2A	58	HDAC1	4	pull down, affinity chromatography technology, affinity chromatography technology	Xia ZB (2003), Xia ZB (2003), Nakamura T (2002)	3
BRCA1	7	E2F4	0	pull down	Wang H (1997)	1
TFDP1	3	E2F4	0	two hybrid, pull down, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology	Sardet C (1995), Dynlacht BD (1997), Beijersbergen RL (1994), Ginsberg D (1994), Trimarchi JM (1998), Hauri S (2016)	6
E2F4	0	ID3	0	two hybrid	Ravasi T (2010)	1
E2F4	0	RBL2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Iavarone A (1999), Litovchick L (2007), Schmit F (2007), Kong LJ (2006), Farkas T (2002), Osterloh L (2007), Yakovlev VA (2013), Martin N (2012), Martin N (2012)	9
FHL2	0	ID3	0	two hybrid	Gao J (2008)	1
LIN9	3	LIN37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Schmit F (2007), Huttlin EL (2015), Huttlin EL (2017)	9
CDK2	0	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Ruffner H (1999), Ruffner H (1999), Ruffner H (1999), Wang H (1997), Chen Y (1996)	5
DNMT3L	2	ASH2L	2	pull down	Pacaud R (2014)	1
XPO1	8	ASH2L	2	affinity chromatography technology	Kirli K (2015)	1
CDK4	2	RBL2	5	enzymatic study	Anders L (2011)	1
DNMT3L	2	HDAC1	4	pull down, pull down, pull down, pull down, affinity chromatography technology	Aapola U (2002), Aapola U (2002), Deplus R (2002), Deplus R (2002), Deplus R (2002)	5
E2F4	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ferreira R (1998), Iavarone A (1999), Chen L (2012)	3
HCFC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Yokoyama A (2004), Wysocka J (2003), Wysocka J (2003), Wysocka J (2003), Mangone M (2010)	5
BRCA1	7	HCFC1	4	affinity chromatography technology	Ertych N (2016)	1
TFDP3	0	E2F4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK2	0	RBL2	5	enzymatic study, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Lacy S (1997), Zhao J (1998), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Howard CM (2000), Huttlin EL (2017)	9
HDAC1	4	MGA	9	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
MOV10	6	LIN9	3	affinity chromatography technology	Castello A (2012)	1
HDAC1	4	RBL1	1	affinity chromatography technology, affinity chromatography technology, pull down	Lai A (1999), Ferreira R (1998), Ferreira R (1998)	3
KMT2A	58	SIN3A	13	affinity chromatography technology, affinity chromatography technology	Yokoyama A (2010), Nakamura T (2002)	2
EGFR	5	AR	3	affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Bonaccorsi L (2004), Bonaccorsi L (2004), Bonaccorsi L (2004), Bonaccorsi L (2004)	4
PML	7	ASF1A	0	imaging technique	Delbarre E (2013)	1
E2F4	0	RNF144A	1	two hybrid	Schlisio S (2002)	1
ASF1A	0	HIRA	5	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang Y (2006), Tang Y (2006), Tang Y (2006), Zhang R (2005), Zhang R (2005), Galvani A (2008), Yang JH (2011), Zhang R (2007), Hein MY (2015), Huttlin EL (2017), Lee JS (2016), Lee JS (2016), Pchelintsev NA (2013), Pchelintsev NA (2013)	14
AR	3	SIN3A	13	affinity chromatography technology	Zhu P (2006)	1
E2F4	0	CDK4	2	affinity chromatography technology	Boldt K (2016)	1
CCDC183	3	E2F4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
E2F4	0	KAT2A	1	affinity chromatography technology	Lang SE (2001)	1
ENO1	3	HDAC1	4	pull down, affinity chromatography technology	Ghosh AK (1999), Ghosh AK (1999)	2
CDK2	0	E2F4	0	affinity chromatography technology	So J (2015)	1
SMAD3	1	RBL1	1	pull down, affinity chromatography technology	Chen CR (2002), Chen CR (2002)	2
DNMT3L	2	SMAD3	1	pull down	Pacaud R (2014)	1
LIN37	0	RBL1	1	affinity chromatography technology, affinity chromatography technology	Schmit F (2007), Schmit F (2007)	2
NCOR2	12	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Guenther MG (2000), Guenther MG (2000), Guenther MG (2000), Fischle W (2002), Fischle W (2002), Guenther MG (2002), Guenther MG (2002), Guenther MG (2002), Guenther MG (2002), Li J (2000), Li J (2000), Li J (2000), Underhill C (2000), Guenther MG (2000), Guenther MG (2000), Kim MY (2006), Wang L (2006), Torres-Padilla ME (2002), Codina A (2005), Wen YD (2000), Rajendran P (2011), Liu A (2006), Bantscheff M (2011), Joshi P (2013), Xu F (2016)	27
NXF1	0	ATAD2	6	affinity chromatography technology	Castello A (2012)	1
ENO1	3	E2F4	0	affinity chromatography technology	Castello A (2012)	1
CCNE1	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McKenzie PP (2003), Shanahan F (1999), Koff A (1992), Koff A (1992), Mayer C (2004), Connor MK (2003), Boudrez A (2000), Varshochi R (2005), Jeong JH (2010), Bustany S (2011), Yeh ES (2006), Hui S (2011), Kim J (2007), Kiviharju-af Haellstroem TM (2007), Abbas T (2007), Nishimura T (2005), Matsumoto Y (2004), Harwell RM (2004), Harwell RM (2004), Peiretti A (2003), Peiretti A (2003), Kim YB (2000), Manenti S (1999), Datta NS (1998), Sheaff RJ (1997), Higashi H (1996), Higashi H (1996), Musgrove EA (1996), Vlach J (1996), Grim JE (2008), Liu S (2009), Ciarallo S (2002), Desai D (1995), Baydoun HH (2010), Baydoun HH (2010), Chu I (2007), Chu I (2007), Levkau B (1998), Poon RY (1996), Zhao J (1998), Zhao J (1998), Larrea MD (2009), Varjosalo M (2013), Varjosalo M (2013), Chan HM (2001), So J (2015), Ungermannova D (2005), Song MS (2011), Huttlin EL (2015), Hein MY (2015), Lin CH (2015), Lin CH (2015), Davis RJ (2017), Huttlin EL (2017)	54