PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDH1	4	TRIM25	5	bioid	Guo Z (2014)	1
OSGEP	1	SPRED1	3	two hybrid	Vinayagam A (2011)	1
TSC22D1	1	SPRED1	3	two hybrid	Vinayagam A (2011)	1
SPRED1	3	SUV39H1	0	two hybrid	Weimann M (2013)	1
TRIM25	5	TTC19	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
CDKN1A	1	SPRED1	3	two hybrid	Vinayagam A (2011)	1
TRIM25	5	SPRED1	3	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	DNAJB11	3	affinity chromatography technology	Abdelmohsen K (2009)	1
NAGK	4	SPRED1	3	two hybrid	Vinayagam A (2011)	1
TRIM25	5	RCC1	2	affinity chromatography technology	Choudhury NR (2017)	1
CDH1	4	SPRED1	3	bioid	Guo Z (2014)	1
PPP1CA	3	SPRED1	3	two hybrid, two hybrid	Esteves SL (2012), Colland F (2004)	2
ELAVL1	0	SPRED1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
FBXW7	2	TRIM25	5	two hybrid	Arroyo R (2015)	1
TRIM25	5	PPP1CA	3	affinity chromatography technology	Choudhury NR (2017)	1
FAM118B	0	SPRED1	3	two hybrid	Vinayagam A (2011)	1
SPRED1	3	TESK1	2	affinity chromatography technology	Chandramouli S (2008)	1
PPP1CA	3	CDH1	4	affinity chromatography technology, bioid	Flores-Delgado G (2007), Guo Z (2014)	2
DNAJB11	3	SPRED1	3	two hybrid	Vinayagam A (2011)	1
FBXW7	2	SPRED1	3	genetic interference	Bailey ML (2015)	1
ELAVL1	0	ZDHHC17	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ZDHHC17	1	SPRED1	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Butland SL (2014), Butland SL (2014), Butland SL (2014)	3
TTC19	0	SPRED1	3	two hybrid	Vinayagam A (2011)	1
RCC1	2	SPRED1	3	two hybrid	Vinayagam A (2011)	1