PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SMAD2	5	CYP11A1	3	two hybrid	Colland F (2004)	1
SMAD3	1	CYP11A1	3	two hybrid	Colland F (2004)	1
SMAD9	0	SMAD2	5	two hybrid	Colland F (2004)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
NLGN3	3	CYP11A1	3	two hybrid, affinity chromatography technology	Shen C (2015), Shen C (2015)	2
CYP11A1	3	FDX1	0	pull down	Wada A (1992)	1
SMAD3	1	SMAD9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD9	0	CYP11A1	3	two hybrid	Colland F (2004)	1