PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MOV10	6	CAV1	0	affinity chromatography technology	Castello A (2012)	1
PTPRF	9	CAV1	0	affinity chromatography technology	Caselli A (2002)	1
CAV1	0	GRK2	4	pull down	Carman CV (1999)	1
HSP90AB1	2	SRC	2	affinity chromatography technology	Karras GI (2017)	1
PLPBP	4	GRK2	4	biochemical	Wan C (2015)	1
RXRB	0	GRK2	4	affinity chromatography technology	Hein MY (2015)	1
ADRB2	0	GRK3	2	pull down	Menard L (1996)	1
GRM1	4	GRK2	4	affinity chromatography technology	Anborgh PH (2005)	1
PRPF4	3	GRK2	4	affinity chromatography technology	Hein MY (2015)	1
GIT1	10	GIT2	2	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology	Kim S (2003), Kim S (2003), Kim S (2003), Huttlin EL (2017)	4
SRC	2	PDGFRB	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee CW (2007), Collin G (2007), Wu CY (2008)	3
GRK2	4	HSP90AA1	7	affinity chromatography technology	Varjosalo M (2013)	1
GNB1	4	PDCL	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography	Howlett AC (2009), Lukov GL (2005), Plimpton RL (2015), Plimpton RL (2015), Plimpton RL (2015)	5
TBC1D14	3	GRK2	4	affinity chromatography technology	Huttlin EL (2017)	1
MDM2	2	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Wang P (2003), Shenoy SK (2008), Girnita L (2005), Girnita L (2005), Nogues L (2011), Shenoy SK (2001), Ahmed MR (2011)	7
PTPRF	9	DNAAF5	4	biochemical	Wan C (2015)	1
GIT2	2	GRK2	4	affinity chromatography technology	Premont RT (2000)	1
AGTR1	4	CAV1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRK2	4	KCNIP3	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ruiz-Gomez A (2007), Ruiz-Gomez A (2007), Ruiz-Gomez A (2007), Ruiz-Gomez A (2007)	4
ARRB1	2	HSP90AA1	7	affinity chromatography technology	Xiao K (2007)	1
GNB2	3	PDCL	2	affinity chromatography technology, affinity chromatography technology	Howlett AC (2009), Huttlin EL (2017)	2
GRK2	4	PEBP1	0	affinity chromatography technology, affinity chromatography technology	Lorenz K (2003), Lorenz K (2003)	2
SLAIN2	2	GRK2	4	affinity chromatography technology	Hein MY (2015)	1
AGTR1	4	ARRB1	2	affinity chromatography technology	Barnes WG (2005)	1
MDM2	2	ACACA	5	affinity chromatography technology	Jacob AG (2014)	1
ADRB2	0	HDAC6	0	protein complementation assay	Kittanakom S (2014)	1
GRK2	4	HSP90AB1	2	affinity chromatography technology	Varjosalo M (2013)	1
CAV1	0	HDAC6	0	affinity chromatography technology	Li Y (2008)	1
GRK2	4	EPHA2	3	two hybrid	Wang J (2011)	1
ADRB2	0	SRC	2	affinity chromatography technology	Cao W (2000)	1
GIT1	10	GRK2	4	affinity chromatography technology, affinity chromatography technology	Premont RT (2000), Premont RT (1998)	2
GRK2	4	RASGRF1	4	two hybrid	Wang J (2011)	1
GRK2	4	GNAQ	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Day PW (2003), Day PW (2003), Cartier A (2011), Sallese M (2000)	4
PTPRF	9	GRK2	4	biochemical	Wan C (2015)	1
GRK2	4	RHO	3	pull down	Gan XQ (2000)	1
GNB1	4	ARRB1	2	affinity chromatography technology, pull down	Yang M (2009), Yang M (2009)	2
HSP90AA1	7	SNCA	0	pull down	Falsone SF (2009)	1
GIT1	10	GRK3	2	affinity chromatography technology	Premont RT (1998)	1
PPWD1	4	GRK2	4	biochemical	Wan C (2015)	1
GNB1	4	GNAQ	1	biochemical	Wan C (2015)	1
MDM2	2	HSP90AB1	2	affinity chromatography technology	Okoro DR (2013)	1
GRK2	4	ARRB1	2	affinity chromatography technology	Nogues L (2011)	1
SRC	2	SNCA	0	enzymatic study	Ellis CE (2001)	1
PTCH1	8	GRK2	4	affinity chromatography technology	Yamaki Y (2016)	1
FERMT2	0	GRK2	4	biochemical	Wan C (2015)	1
SRC	2	GRM1	4	affinity chromatography technology, affinity chromatography technology	Hirose M (2004), Hirose M (2004)	2
ADRB2	0	GNB1	4	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Gales C (2005), Roy SJ (2013), Roy SJ (2013)	3
SRC	2	MDM2	2	unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Batuello CN (2015), Batuello CN (2015), Batuello CN (2015), Batuello CN (2015), Batuello CN (2015)	5
HDAC6	0	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology	New M (2013), Watson GW (2016)	2
MOV10	6	DNAAF5	4	affinity chromatography technology	Castello A (2012)	1
DDX6	0	PPWD1	4	biochemical	Wan C (2015)	1
PLPBP	4	PAPOLA	5	biochemical	Wan C (2015)	1
PTCH1	8	GRK3	2	affinity chromatography technology	Yamaki Y (2016)	1
GRK2	4	NARS2	6	biochemical	Wan C (2015)	1
ARRB1	2	PRPF4	3	affinity chromatography technology	Xiao K (2007)	1
GRK2	4	GNA15	1	pull down, affinity chromatography technology	Day PW (2003), Day PW (2003)	2
GRM1	4	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CAV1	0	PDGFRB	8	affinity chromatography technology, biochemical, pull down	Yamamoto M (1999), Yamamoto M (1999), Yamamoto M (1999)	3
GNB2	3	GNAQ	1	biochemical	Wan C (2015)	1
GRK2	4	FSHR	2	enzymatic study	Lazari MF (1999)	1
GRK2	4	PDCL	2	enzymatic study	Ruiz-Gomez A (2000)	1
SRC	2	RASGRF1	4	enzymatic study	Giglione C (2001)	1
CTR9	10	GRK2	4	affinity chromatography technology	Hein MY (2015)	1
CCR4	0	GRK2	4	affinity chromatography technology	Inngjerdingen M (2000)	1
ARRB1	2	ACACA	5	affinity chromatography technology	Xiao K (2007)	1
PTPRF	9	PPWD1	4	biochemical	Wan C (2015)	1
GPR17	0	GRK2	4	affinity chromatography technology	Fumagalli M (2015)	1
SRC	2	PDE6G	0	affinity chromatography technology, affinity chromatography technology, pull down	Wan KF (2003), Wan KF (2003), Wan KF (2003)	3
CAV1	0	SRC	2	pull down	Li S (1996)	1
DNAAF5	4	GRK2	4	biochemical	Wan C (2015)	1
CAV1	0	EDNRB	3	affinity chromatography technology, pull down	Yamaguchi T (2003), Yamaguchi T (2003)	2
GNB2	3	GRK2	4	enzymatic study	Zha Z (2015)	1
ARRB1	2	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosano L (2009), Rosano L (2009), Buchanan FG (2006), Buchanan FG (2006), Lee J (2013)	5
MDM2	2	HSP90AA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, biochemical, unspecified method, affinity chromatography technology	Lu TL (2010), Burch L (2004), Burch L (2004), Burch L (2004), Burch L (2004), Burch LR (2004), Okoro DR (2013)	7
MOV10	6	GIT2	2	affinity chromatography technology	Castello A (2012)	1
SNCA	0	ARRB1	2	affinity chromatography technology	Kim KS (2010)	1
SNCA	0	GRK2	4	unspecified method	Woods WS (2007)	1
MDM2	2	ADRB2	0	enzymatic study	Shenoy SK (2001)	1
GRK2	4	GNB1	4	affinity chromatography technology, pull down, affinity chromatography technology	Seo M (2007), Carman CV (2000), Iacovelli L (2004)	3
CSNK2B	5	MDM2	2	enzymatic study	Goetz C (1999)	1
HSP90AA1	7	FBXO25	1	affinity chromatography technology	Taipale M (2012)	1
HSP90AA1	7	EPHA2	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
CAV1	0	PTCH1	8	affinity chromatography technology, affinity chromatography technology	Karpen HE (2001), Karpen HE (2001)	2
HSP90AB1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Cheng MB (2010), Gano JJ (2010), Skarra DV (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Wan C (2015), Hein MY (2015)	8
HSP90AA1	7	PRKCB	4	affinity chromatography technology	Taipale M (2012)	1
GRK2	4	PDC	0	enzymatic study	Ruiz-Gomez A (2000)	1
CCR4	0	GRK3	2	affinity chromatography technology	Inngjerdingen M (2000)	1
ADRB2	0	GRK2	4	affinity chromatography technology, enzymatic study, pull down	Fan G (2001), Lorenz K (2003), Menard L (1996)	3
HSP90AA1	7	SRC	2	affinity chromatography technology, affinity chromatography technology	Hutchison KA (1992), Tsutsumi S (2012)	2
GRK2	4	PDE6G	0	affinity chromatography technology, affinity chromatography technology, pull down	Wan KF (2003), Wan KF (2003), Wan KF (2003)	3
MOV10	6	GRK2	4	affinity chromatography technology	Castello A (2012)	1
GRK2	4	ACACA	5	affinity chromatography technology	Varjosalo M (2013)	1
PAPOLA	5	GRK2	4	biochemical	Wan C (2015)	1
PDGFRB	8	GRK2	4	affinity chromatography technology	Freedman NJ (2002)	1
GRK2	4	PRKCB	4	pull down, affinity chromatography technology	Yang XL (2003), Yang XL (2003)	2
GIT1	10	PTPRF	9	affinity chromatography technology	Ko J (2003)	1
HDAC6	0	GRK2	4	affinity chromatography technology, enzymatic study, imaging technique	Lafarga V (2012), Lafarga V (2012), Lafarga V (2012)	3
HSP90AA1	7	CAV1	0	affinity chromatography technology	Ji Y (2007)	1
CAV1	0	SNCA	0	pull down	Madeira A (2011)	1
CSNK2B	5	GRK2	4	two hybrid	Vinayagam A (2011)	1
PPP1R16B	2	GRK2	4	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	PDGFRB	8	affinity chromatography technology	Taipale M (2012)	1
MDM2	2	GRK2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nogues L (2011), Nogues L (2011), Salcedo A (2006), Fumagalli M (2015)	4
MOV10	6	PEBP1	0	affinity chromatography technology	Castello A (2012)	1
AGTR1	4	GRK2	4	affinity chromatography technology	Freedman NJ (1997)	1
EDNRB	3	GRK2	4	affinity chromatography technology	Freedman NJ (1997)	1
GRK2	4	SRC	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Wan KF (2003)	2
HDAC6	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Kekatpure VD (2009), Rao R (2008), Bali P (2005), Kovacs JJ (2005), New M (2013), Rao R (2012), Kovacs JJ (2005)	7
GRK2	4	GRK3	2	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2017)	2
FBXO25	1	GRK2	4	enzymatic study	Teixeira FR (2013)	1
ADRB2	0	GNB2	3	affinity chromatography technology, affinity chromatography technology	Roy SJ (2013), Roy SJ (2013)	2
MOV10	6	ACACA	5	affinity chromatography technology	Castello A (2012)	1
DDX6	0	GRK2	4	biochemical	Wan C (2015)	1